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Hot Topics of the Day|PHGKB
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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Worldwide Prevalence of Familial Hypercholesterolemia: Meta-Analyses of 11 Million Subjects.
Beheshti Sabina O et al. Journal of the American College of Cardiology 2020 May 75(20) 2553-2566

CDC podcast, May 26, 2020 Brand

SPHERES is a new CDC national genomics consortium established to coordinate SARS-CoV-2 sequencing in laboratories across the United States. The podcast discusses how this new effort will allow scientists at CDC and other public health agencies to monitor changes in the virus as it circulates whiles providing crucial diagnostic and potential treatment information.

Use of apps in the COVID-19 response and the loss of privacy protection
T Sharma et al, Nature Medicine, May 26, 2020

Mobile apps provide a convenient source of tracking and data collection to fight against the spread of COVID-19. We report our analysis of 50 COVID-19-related apps, including their use and their access to personally identifiable information, to ensure that the right to privacy and civil liberties are protected.

No evidence for allelic association between Covid-19 and ACE2 genetic variants by direct exome sequencing in 99 SARS-CoV-2 positive patients
A Novelli et al, MEDRXIV May 26, 2020

A machine learning approach predicts future risk to suicidal ideation from social media data
A Roy, et al, NPJ Digital Medicine, May 26, 2020

Machine learning analysis of social media data represents a promising way to capture longitudinal environmental influences contributing to individual risk for suicidal thoughts and behaviors. Our objective was to generate an algorithm capable of predicting future risk to suicidal thought by analyzing publicly available Twitter data.

Local cellular cues that influence the immunology of colorectal cancer treatment
GP Donaldson et al, Nature Medicine, May 25, 2020

Therapeutic interventions in colorectal cancer are dependent on immune responses to dying epithelial cells that are modulated by specific members of the gut microbiota.

Genomics-guided pre-clinical development of cancer therapies
HE Francies et al, Nature Cancer, May 2020

We consider the evidence that supports genomics-guided drug development and review the concept of oncogene addiction, including recent findings that inform this therapeutic approach. We consider non-oncogene addiction and how this synthetic-lethal paradigm could expand the range of new therapies, particularly for currently undruggable cancers.

Precision psychiatry with immunological and cognitive biomarkers: a multi-domain prediction for the diagnosis of bipolar disorder or schizophrenia using machine learning
BS Fernandes et al, Translational Psychiatry, May 24, 2020

We developed a probabilistic multi-domain data integration model consisting of immune and inflammatory biomarkers in peripheral blood and cognitive biomarkers using machine learning to predict diagnosis of bipolar disorder and schizophrenia. 416 participants were included for blood, cognition and combined biomarkers analysis.

Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.