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Hot Topics of the Day|PHGKB
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03/20/2021

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

First wastewater surveillance-based city zonation for effective COVID-19 pandemic preparedness powered by early warning: A study of Ahmedabad, India
M Kumar et al, MEDRXIV, March 20, 2021

Predicting clinical outcomes in the Machine Learning era: The Piacenza score a purely data driven approach for mortality prediction in COVID-19 Pneumonia
G Halasz et al, MEDRXIV, March 20, 2021

Pulmonary Fibrosis after COVID-19 is Associated with Severity of Illness and Blood Leukocyte Telomere Length
CF McGroder et al, MEDRXIV, March 20, 2021

Targeted Hybridization Capture of SARS-CoV-2 and Metagenomics Enables Genetic Variant Discovery and Nasal Microbiome Insights
DN Szakal et al, MEDRXIV, March 20, 2021

Exploring causal relationships between COVID-19 and cardiometabolic disorders: A bi-directional Mendelian randomization study
Y Xiang et al, MEDRXIV, March 20, 2021

Within-country age-based prioritisation, global allocation, and public health impact of a vaccine against SARS-CoV-2: a mathematical modelling analysis
AB Hogan et al, MEDRXIV, March 20, 2021

Modelling the impact of rapid tests, tracing and distancing in lower-income countries suggest optimal policies varies with rural-urban settings
X Jiang et al, MEDRXIV, March 20, 2021

Antibody evasion by the Brazilian P.1 strain of SARS-CoV-2
W Dejniratissei et al, BIORXIV, March 19, 2021

The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2, in vitro
RT Makino et al, BIORXIV, March 19, 2021

Resources for Disproportionately Affected Communities
CDC, March 2021 Brand

Connecticut Uses Social Media to Engage Long-term Care Residents- States continue to find COVID-19-safe ways to maintain communication with citizens
CDC, March 2021 Brand

Nowcasting epidemics of novel pathogens: lessons from COVID-19.
Wu Joseph T et al. Nature medicine 2021 3 (3) 388-395

In this Perspective, we share our views on the functional aims, rationale, data requirements and challenges of nowcasting at different stages of an epidemic, drawing on the ongoing COVID-19 experience. We highlight how recent advances in the computational and laboratory sciences could be harnessed to complement traditional approaches to enhance the scope, timeliness, reliability and utility of epidemic nowcasting.

A more contagious coronavirus variant is spreading across the US. Can vaccines stop it?
M Fox, CNN, March 21, 2021

Rare COVID reactions might hold key to variant-proof vaccines - Some people mount an immune response able to fend off a menagerie of coronavirus variants.
E Callaway, Nature, March 19, 2021

Leveraging risk communication science across US federal agencies
WMP Klein et al, Nature Human Behavior, March 18, 2021

Many US federal agencies apply principles from risk communication science across a wide variety of hazards. In so doing, they identify key research and practice gaps that, if addressed, could help better serve the nation’s communities and greatly enhance practice, research, and policy development.

Large socio-economic, geographic and demographic disparities exist in exposure to school closures
Z Parolin et al, Nature Human Behavior, March 2021

We introduce a U.S. School Closure and Distance Learning Database that tracks in-person visits across more than 100,000 schools throughout 2020. The database, which we make publicly accessible and update monthly, describes year-over-year change in in-person visits to each school throughout 2020 to estimate whether the school is engaged in distance learning. Our findings reveal that school closures from September to December 2020 were more common in schools with lower third-grade math scores and higher shares of students from racial/ethnic minorities, who experience homelessness, have limited English proficiency and are eligible for free/reduced-price school lunches.

Health Literacy in the Digital Age: Applications to Genomics
CDC Webinar, June 10, 2021 Brand

With the recent COVID-19 pandemic, patients are turning more to online information sources and telehealth services to address their healthcare needs. Digital health literacy plays an increasingly important role in understanding information and in patient-provider communication. This has implications across disease prevention and the healthcare continuum including the field of genetics. Register today to attend our June 10, 2021 webinar.

Assessment of medication self-administration using artificial intelligence
M Zhao et al, Nature Medicine, March 18, 2021

We present a contactless and unobtrusive artificial intelligence (AI) framework that can detect and monitor MSA errors by analyzing the wireless signals in the patient’s home, without the need for physical contact. The system was developed by observing self-administration conducted by volunteers and evaluated by comparing its prediction with human annotations. Findings from this study demonstrate that our approach can automatically detect when patients use their inhalers (area under the curve (AUC)?=?0.992) or insulin pens (AUC?=?0.967), and assess whether patients follow the appropriate steps for using these devices (AUC?=?0.952).


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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