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Hot Topics of the Day|PHGKB
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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Big Data and Digital Solutions: Laying the Foundation for Cardiovascular Population Management CME .
Nasir Khurram et al. Methodist DeBakey cardiovascular journal 16(4) 272-282

Big data analytics and digital application platforms-such as patient care dashboards, clinical decision support systems, mobile patient engagement applications, and key performance indicators-offer unique opportunities for value-based healthcare delivery and efficient cardiovascular population management. Successful implementation of big data solutions must include a multidisciplinary approach.

American Heart Month 2021- Feeling the pressure? We can help.
CDC, February 2021 Brand

February is American Heart Month, a time when all people can focus on their cardiovascular health. The CDC Division for Heart Disease and Stroke Prevention is shining a light on hypertension (high blood pressure), a leading risk factor for heart disease and stroke.

Demographic Characteristics of Persons Vaccinated During the First Month of the COVID-19 Vaccination Program — United States, December 14, 2020–January 14, 2021
EM Painter et al, MMWR, February 1, 2021

During the first month of the U.S. COVID-19 vaccination program, approximately 13,000,000 persons received =1 dose of vaccine. Among persons with demographic data, 63.0% were women, 55.0% were aged =50 years, and 60.4% were non-Hispanic White.

Sputnik V COVID-19 vaccine candidate appears safe and effective
I Jones et al, Lancet, February 2, 2021

Genetically predicted serum vitamin D and COVID-19: a Mendelian randomization study
BK Patchen et al, MEDRXIV, February 1, 2021

Predicting Prognosis in COVID-19 Patients using Machine Learning and Readily Available Clinical Data
TW Campbell et al, MEDRXIV, February 1, 2021

MOATAI-VIR - an AI algorithm that predicts severe adverse events and molecular features for COVID-19's complications
CA Astore, et al, MEDRXIV, February 1, 2021

Emergence of first strains of Sars-CoV-2 lineage B.1.1.7 in Romania
A Lobiuc et al, MEDRXIV, February 1, 2021

Spatial Inequities in COVID-19 Testing, Positivity, Confirmed Cases and Mortality in 3 US Cities: an Ecological Study
U Bilal et al, MEDRXIV, February 1, 2021

SARS-CoV-2 B.1.1.7 escape from mRNA vaccine-elicited neutralizing antibodies
D Collier et al, MEDRXIV, February 2, 2021

We measured neutralising antibody responses following a single immunization using pseudoviruses expressing the wild-type Spike protein or the 8 mutations found in the B.1.1.7 Spike protein. The vaccine sera exhibited a broad range of neutralizing titres against the wild-type pseudoviruses (<1:4 to 3449) that were reduced against B.1.1.7 variant by 3.85 fold (IQR 2.68-5.28). This reduction was also evident in sera from some convalescent patients.

Learning from scaling up ultra-rapid genomic testing for critically ill children to a national level
S Best et al, NPJ Genomic Medicine, January 2021

In scaling up an ultra-rapid genomics program, we used implementation science principles to design and investigate influences on implementation and identify strategies required for sustainable “real-world” services. Interviews with key professionals revealed the importance of networks and relationship building, leadership, culture, and the relative advantage afforded by ultra-rapid genomics in the care of critically ill children.

Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.