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May 15, 2021

Last Posted: May-15-2021 08:05:57

Precision medicine needs an equity agenda
Nature Medicine editorial, May 14, 2021

Twenty years after release of the first human genome, genomic profiling is becoming a tool in mainstream precision medicine across health conditions. Realizing its full potential, however, will require gaining a more diverse perspective of genetic variability across human populations, and their diversity within, to ensure that the clinical application of genetics is equitable and that it reaches global impact in the next twenty years.

An ensemble of neural networks provides expert-level prenatal detection of complex congenital heart disease
R Arnaout et al, Nature Medicine, May 14, 2021

Deep learning for detecting congenital heart disease in the fetus
SA Morris et al, Nature Medicine, May 14, 2021

Despite substantial advances in obstetric ultrasound imaging over the past several decades, a large proportion of CHD still goes unrecognized in the prenatal period. New advances in machine learning could facilitate and reduce disparities in the prenatal diagnosis of congenital health disease, the most common and lethal birth defect.

Deep learning in histopathology: the path to the clinic
J van der Laak et al, Nature Medicine, May 14, 2021

Machine learning techniques have great potential to improve medical diagnostics, offering ways to improve accuracy, reproducibility and speed, and to ease workloads for clinicians. In the field of histopathology, deep learning algorithms have been developed that perform similarly to trained pathologists for tasks such as tumor detection and grading. However, despite these promising results, very few algorithms have reached clinical implementation.

Mobile Health: making the leap to research and clinics
JP Ku et al, NPJ Digital Medicine, May 14, 2021

Health applications for mobile and wearable devices continue to experience tremendous growth, but their impact on healthcare has yet to be fully realized. This commentary introduces three articles in a special issue that provides guidance on how to successfully address translational barriers to bringing mobile health technologies into clinical research and care. We also discuss how the cross-organizational sharing of data, software, and other digital resources can lower such barriers and accelerate progress across mobile health

Impact of BNT162b first vaccination on the immune transcriptome of elderly patients infected with the B.1.351 SARS-CoV-2 variant
L Knabl et al, MEDRXIV, May 14, 2021

Immune Responses to COVID-19 mRNA Vaccines in Patients with Solid Tumors on Active, Immunosuppressive Cancer Therapy
RT Shroff et al, MEDRXIV, May 14, 2021

Cardiovascular vulnerability predicts hospitalisation in primary care clinically suspected and confirmed COVID-19 patients: a model development and validation study
FS von Royen et al, MEDRXIV, May 14, 2021

SARS-CoV-2 lineage dynamics in England from January to March 2021 inferred from representative community samples
O Eales et al, MEDRXIV, May 14, 2021

Transmission roles of symptomatic and asymptomatic COVID-19 cases: a modeli
J Tan et al, MEDRXIV, May 14, 2021

How the United States Beat the Variants, for Now- The country has managed to avoid a variant-fueled spike in coronavirus cases. Scientists say we were lucky.
C Zimmer et al, NY Times, May 14, 2021

Experts point to a combination of factors — masks, social distancing and other restrictions, and perhaps a seasonal wane of infections — that bought crucial time for tens of millions of Americans to get vaccinated. They also credit a good dose of serendipity, as B.1.1.7, unlike some of its competitors, is powerless against the vaccines.


Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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