May 15, 2021
Last Posted: May-15-2021 08:05:57
Precision medicine needs an equity agenda
Nature Medicine editorial, May 14, 2021
Twenty years after release of the first human genome, genomic profiling is becoming a tool in mainstream precision medicine across health conditions. Realizing its full potential, however, will require gaining a more diverse perspective of genetic variability across human populations, and their diversity within, to ensure that the clinical application of genetics is equitable and that it reaches global impact in the next twenty years.
Deep learning in histopathology: the path to the clinic
J van der Laak et al, Nature Medicine, May 14, 2021
Machine learning techniques have great potential to improve medical diagnostics, offering ways to improve accuracy, reproducibility and speed, and to ease workloads for clinicians. In the field of histopathology, deep learning algorithms have been developed that perform similarly to trained pathologists for tasks such as tumor detection and grading. However, despite these promising results, very few algorithms have reached clinical implementation.
Mobile Health: making the leap to research and clinics
JP Ku et al, NPJ Digital Medicine, May 14, 2021
Health applications for mobile and wearable devices continue to experience tremendous growth, but their impact on healthcare has yet to be fully realized. This commentary introduces three articles in a special issue that provides guidance on how to successfully address translational barriers to bringing mobile health technologies into clinical research and care. We also discuss how the cross-organizational sharing of data, software, and other digital resources can lower such barriers and accelerate progress across mobile health
Impact of BNT162b first vaccination on the immune transcriptome of elderly patients infected with the B.1.351 SARS-CoV-2 variant
L Knabl et al, MEDRXIV, May 14, 2021
Immune Responses to COVID-19 mRNA Vaccines in Patients with Solid Tumors on Active, Immunosuppressive Cancer Therapy
RT Shroff et al, MEDRXIV, May 14, 2021
Cardiovascular vulnerability predicts hospitalisation in primary care clinically suspected and confirmed COVID-19 patients: a model development and validation study
FS von Royen et al, MEDRXIV, May 14, 2021
SARS-CoV-2 lineage dynamics in England from January to March 2021 inferred from representative community samples
O Eales et al, MEDRXIV, May 14, 2021
Transmission roles of symptomatic and asymptomatic COVID-19 cases: a modeli
J Tan et al, MEDRXIV, May 14, 2021
How the United States Beat the Variants, for Now- The country has managed to avoid a variant-fueled spike in coronavirus cases. Scientists say we were lucky.
C Zimmer et al, NY Times, May 14, 2021
Experts point to a combination of factors — masks, social distancing and other restrictions, and perhaps a seasonal wane of infections — that bought crucial time for tens of millions of Americans to get vaccinated. They also credit a good dose of serendipity, as B.1.1.7, unlike some of its competitors, is powerless against the vaccines.
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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