Emergence of SARS-CoV-2 B.1.1.7 Lineage — United States, December 29, 2020–January 12, 2021
SE Galloway et al, MMWR, January 15, 2021
Modeling data indicate that B.1.1.7 has the potential to increase the U.S. pandemic trajectory in the coming months. CDC’s system for genomic surveillance and the effort to expand sequencing will increase the availability of timely U.S. genomic surveillance data.
Immune determinants of COVID-19 disease presentation and severity.
Brodin Petter et al. Nature medicine 2021 Jan (1) 28-33
The most important determinant of disease severity is age, with individuals over 65 years having the greatest risk of requiring intensive care, and men are more susceptible than women. In contrast to other respiratory viral infections, young children seem to be less severely affected. It is now clear that mild to severe acute infection is not the only outcome of COVID-19, and long-lasting symptoms are also possible.
Is precision medicine relevant in the age of COVID-19?
Zhou Amy et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021 Jan
Precision medicine and precision public health interventions in COVID-19 are promising but need to complement efforts to strengthen public health infrastructure and address fundamental social, economic, and environmental causes of illness.
Emergence and Evolution of a Prevalent New SARS-CoV-2 Variant in the United States
AA Pater et al, BIORXIV, January 13, 2021
Genomic virus surveillance can lead to early identification of new variants and inform proper response during a pandemic. Using this approach, we have identified a new variant of the SARS-CoV-2 virus that emerged in the United States (U.S.) early in the coronavirus disease (COVID-19) pandemic and has become one of the most prevalent U.S variants. This new variant within the B.1.2 lineage referred to here as 20C-US, has not yet spread widely to other countries.
Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70
S Kemp et al, BIORXIV, January 14, 2021
The lethal triad: SARS-CoV-2 Spike, ACE2 and TMPRSS2. Mutations in host and pathogen may affect the course of pandemic.
M Calcagnile et al, BIORXIV, January 14, 2021
Surveillance of genetic diversity and evolution in locally transmitted SARS-CoV-2 in Pakistan during the first wave of the COVID-19 pandemic
M Shakeel et al, BIORXIV, January 14, 2021
Spatial Inequities in COVID-19 Testing, Positivity, Confirmed Cases and Mortality in 3 US Cities: an Ecological Study
U Bilal et al, MEDRXIV, January 13, 2021
High throughput wastewater SARS-CoV-2 detection enables forecasting of community infection dynamics in San Diego county
S Karthitheyan et al, MEDRXIV, January 14, 2021
People with an intellectual disability should be prioritised for vaccination
KM Lodge et al, BMJ, January 15, 2021
Challenges and Opportunities for Communication about the Role of Genomics in Public Health.
Allen Caitlin G et al. Public health genomics 2021 Jan 1-7
We describe 5 common communication challenges about the role of genomics in public health: (1) communicating that using genomics to assess rare diseases can have an impact on public health; (2) providing evidence that genetic factors can add important information to environmental, behavioral, and social determinants of health; (3) communicating that although genetic factors are nonmodifiable, they can increase the impact of public health programs and communication strategies; (4) addressing the concern that genomics is not ready for clinical practice; and (5) communicating that genomics is valuable beyond the domain of health care and can be integrated as part of public health programs.