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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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116 hot topic(s) found with the query "Zika"

Development of an amplicon-based sequencing approach in response to the global emergence of human monkeypox virus
NFG Chen et al, MEDRXIV, January 13, 2023 (Posted: Jan 16, 2023 7AM)

Highly multiplexed amplicon-based sequencing (PrimalSeq) was initially developed for sequencing of Zika virus, and later adapted as the main sequencing approach for SARS-CoV-2. Here, we used PrimalScheme to develop a primer scheme for human monkeypox virus that can be used with many sequencing and bioinformatics pipelines implemented in public health laboratories during the COVID-19 pandemic. We sequenced clinical samples that tested presumptive positive for human monkeypox virus with amplicon-based and metagenomic sequencing approaches.

First genetically modified mosquitoes released in the United States
E Watz, Nature News, May 4, 2021 (Posted: May 05, 2021 7AM)

After a decade of fighting for regulatory approval and public acceptance, a biotechnology firm has released genetically engineered mosquitoes into the open air in the United States for the first time. The experiment, launched this week in the Florida Keys tests a method for suppressing populations of wild Aedes aegypti mosquitoes, which can carry diseases such as Zika, dengue, chikungunya and yellow fever.

RNA vaccines: an introduction
PHG Foundation, November 2020 (Posted: Nov 26, 2020 8AM)

Conventional vaccine approaches have not been as effective against rapidly evolving pathogens like influenza or emerging disease threats such as the Ebola, Zika viruses or COVID-19. RNA based vaccines could have an impact in these areas due to their shorter manufacturing times and greater effectiveness. Beyond infectious diseases, RNA vaccines have potential as novel therapeutic options for major diseases such as cancer.

Neurodevelopmental Abnormalities Associated With In Utero Zika Virus Infection in Infants and Children-The Unfolding Story.
Honein Margaret A et al. JAMA pediatrics 2020 Jan (Posted: Jan 09, 2020 8AM)

It remains unknown whether the 90% to 95% of infants potentially congenitally exposed but without Zika virus–associated birth defects have a higher-than-baseline risk of neurodevelopmental abnormalities and, if so, how these disabilities may manifest over time.

Modified mosquitoes reduce cases of dengue fever- Insects infected with a disease-inhibiting bacterium were released in communities in Asia and South America
E Callaway, Nature, November 27, 2019 (Posted: Nov 29, 2019 9AM)

The findings, presented on 21 November at the annual meeting of the American Society of Tropical Medicine and Hygiene in National Harbor, Maryland, come from experimental releases of mosquitoes that carry Wolbachia bacteria, which block the replication of mosquito-borne pathogens such as the dengue, chikungunya and Zika viruses.

Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly.
Link Nichole et al. Developmental cell 2019 Nov (Posted: Nov 25, 2019 8AM)

-Ankle2 interacts with Ballchen/VRK1 to regulate brain development in Drosophila; Ankle2/VRK1 pathway affects asymmetric protein localization during neuroblast division; ANKLE2 and VRK1 are associated with human microcephaly; The Zika virus protein NS4A interacts with and inhibits the ANKLE2 pathway.

Tracking hidden Zika
H Stover, Nature Medicine, October 7,2019 (Posted: Oct 08, 2019 8AM)

An international group of scientists employed a combined approach of analyzing travel-associated Zika cases and performing clinical sequencing to identify a previously unreported Zika virus outbreak that occurred in Cuba in 2017. Their strategy suggests a complementary framework for outbreak monitoring.

Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural Population.
Evans Benjamin R et al. Scientific reports 2019 Sep (1) 13047 (Posted: Sep 15, 2019 8AM)

To control the mosquito-borne diseases yellow fever, dengue, chikungunya, and Zika fevers, a strain of transgenically modified Aedes aegypti mosquitoes containing a dominant lethal gene has been developed. Approximately 450 thousand males of this strain were released each week for 27 months in Jacobina, Bahia, Brazil.

Outsmarting Outbreaks: Using Genomics to Track Viruses
Scripps Institute, video, September 5, 2019 (Posted: Sep 08, 2019 2PM)

In recent years, new and emerging diseases such as West Nile, Ebola and Zika have caught national and international responders off guard. In an increasingly interconnected world, improving disease detection, surveillance and diagnostics tools is critical to preventing global pandemics.

Cuba’s untold Zika outbreak uncovered An unreported spike in cases from 2017 is revealed through international travellers, a technique that could help with early detection in other epidemics.
Nature, August 22, 2019 (Posted: Aug 26, 2019 3PM)

Discovery of ‘hidden’ outbreak hints that Zika virus can spread silently
Scripps Research, August 22, 2019 (Posted: Aug 26, 2019 9AM)

A team of scientists at Scripps Research, working in concert with several other organizations, uncovered a "hidden" outbreak in Cuba by overlaying air-travel patterns with genomic sequencing of virus samples from infected travelers.

Zika Birth Defects Surveillance
CDC, 2019 Brand (Posted: Jun 19, 2019 8AM)

Gene variations linked to severity of Zika-related birth defects, small NIH study suggests
NIH, September 17, 2018 Brand (Posted: Sep 17, 2018 9AM)

Why is congenital Zika syndrome asymmetrically distributed among human populations?
Barbeito-Andrés Jimena et al. PLoS biology 2018 Aug (8) e2006592 (Posted: Aug 29, 2018 0PM)

Zika-associated health and development problems in children
(Posted: Aug 17, 2018 10AM)

Zika in Babies in US Territories- Monitoring early health and development
CDC Vital Signs, August 2018 Brand (Posted: Aug 07, 2018 1PM)

A home test for Zika? CRISPR may make it possible
J Cohen, Science, Apr 27, 2018 (Posted: Apr 27, 2018 0PM)

Recognizing the Global Impact of Zika Virus Infection during Pregnancy.
Honein Margaret A et al. The New England journal of medicine 2018 Mar (11) 1055-1056 (Posted: Mar 15, 2018 8AM)

Public Health Approach to Addressing the Needs of Children Affected by Congenital Zika Syndrome.
Broussard Cheryl S et al. Pediatrics 2018 Feb (Suppl 2) S146-S153 (Posted: Mar 04, 2018 6PM)

Zika and Public Health: Understanding the Epidemiology and Information Environment.
MacDonald Pia D M et al. Pediatrics 2018 Feb (Suppl 2) S137-S145 (Posted: Mar 04, 2018 6PM)

For the first time in humans, Zika syndrome susceptibility linked to genetic background
Science Daily, Feb 2, 2018 (Posted: Feb 03, 2018 10AM)

Birth Defects Potentially Related to Zika Virus Infection During Pregnancy in the United States
B Fitzgerald et al, JAMA, Jan 25, 2018 (Posted: Jan 26, 2018 9AM)

AMD in Action: CDC Scientists Use AMD Methods to Develop Diagnostic Tools for Zika Virus
Brand (Posted: Jan 25, 2018 11AM)

Health and Development at Age 19-24 Months of 19 Children Who Were Born with Microcephaly and Laboratory Evidence of Congenital Zika Virus Infection During the 2015 Zika Virus Outbreak - Brazil, 2017.
Satterfield-Nash Ashley et al. MMWR. Morbidity and mortality weekly report 2017 Dec (49) 1347-1351 (Posted: Dec 15, 2017 9AM)

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly.
Yuan Ling et al. Science (New York, N.Y.) 2017 Sep (Posted: Nov 17, 2017 8AM)

Recent Perspectives on Genome, Transmission, Clinical Manifestation, Diagnosis, Therapeutic Strategies, Vaccine Developments, and Challenges of Zika Virus Research.
Shankar Apoorva et al. Frontiers in microbiology 2017 1761 (Posted: Oct 24, 2017 9AM)

Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection - United States, October 2017.
Adebanjo Tolulope et al. MMWR. Morbidity and mortality weekly report 2017 Oct (41) 1089-1099 (Posted: Oct 24, 2017 9AM)

Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine — Preliminary Report
P Tebas et al, NEJM, October 3, 2017 (Posted: Oct 04, 2017 7PM)

How Zika Became So Dangerous For Babies
NPR, All things considered, Sep 28, 2017 (Posted: Sep 28, 2017 9PM)

A single genetic glitch may explain how Zika became so dangerous
Reuters News, Sep 29, 2017 (Posted: Sep 28, 2017 7PM)

Outcomes of Pregnancies with Laboratory Evidence of Possible Zika Virus Infection in the United States and the US Territories
Brand (Posted: Sep 19, 2017 9AM)

Zika genomics urgently need standardized and curated reference sequences
K Theys et al, PLOS Pathogens, Sep 7, 2017 (Posted: Sep 09, 2017 0PM)

Neurologic Complications Associated With the Zika Virus in Brazilian Adults.
da Silva Ivan Rocha Ferreira et al. JAMA neurology 2017 Aug (Posted: Aug 18, 2017 9AM)

The Expanding Spectrum of Zika Virus Infections of the Nervous System.
Tyler Kenneth L et al. JAMA neurology 2017 Aug (Posted: Aug 18, 2017 9AM)

Zika Response & Success Stories
Brand (Posted: Aug 10, 2017 8AM)

What you need to know
Brand (Posted: Aug 01, 2017 9AM)

A CRISPR toolbox to study virus-host interactions.
Puschnik Andreas S et al. Nature reviews. Microbiology 2017 Jun (6) 351-364 (Posted: Jul 25, 2017 9AM)

Zika virus genome biology and molecular pathogenesis.
Wang Anyou et al. Emerging microbes & infections 2017 Mar (3) e13 (Posted: Jul 25, 2017 9AM)

Update: Interim Guidance for Health Care Providers Caring for Pregnant Women with Possible Zika Virus Exposure — United States (Including U.S. Territories), July 2017
MMWR, July 24, 2017 Brand (Posted: Jul 25, 2017 9AM)

Should you be tested for Zika?
Brand (Posted: Jun 20, 2017 11AM)

CDC analysis of data from US territories finds serious birth defects in about 1 in 12 fetuses or infants of pregnant women with Zika infection in the first trimester
CDC, June 7, 2017 Brand (Posted: Jun 09, 2017 8AM)

Testing for Zika Virus
Brand (Posted: Jun 05, 2017 0PM)

Tracing Zika’s Spread Through Genetics
DNA sequencing reveals that the virus responsible for the recent outbreak in the Americas originated in Brazil in 2014 and circulated undetected for months before the first cases were reported., The Scientist, May 2017 (Posted: May 29, 2017 2PM)

Zika spread secrets tracked through new gene sequencing study
Oxford University, May 2017 (Posted: May 27, 2017 0PM)

Zika virus likely circulated in the Americas long before its detection during the 2015-16 epidemic
Broad Institute, May 24, 2017 (Posted: May 24, 2017 5PM)

Establishment and cryptic transmission of Zika virus in Brazil and the Americas
NR Faria et al, Nature, May 2017 (Posted: May 24, 2017 5PM)

Genomic epidemiology reveals multiple introductions of Zika virus into the United States
ND Grubaugh et al, Nature, May 24, 2017 (Posted: May 24, 2017 1PM)

Zika Virus - Protecting Pregnant Women and Babies
CDC Vital Signs, April 2017 Brand (Posted: Apr 05, 2017 10AM)

Ensure Accuracy in Zika Testing New for 2017: Vector-Borne Disease Molecular Proficiency Testing from the CAP
College of American Pathologists, April 2017 (Posted: Apr 03, 2017 7PM)

US Government moves forward with tests of novel Zika vaccines-flexible vaccines made from DNA
E Mullin, Technology Review, April 3, 2017 (Posted: Apr 03, 2017 7PM)

CDC study estimates 20-fold increase in certain types of birth defects in pregnancies with possible Zika infection compared with pre-Zika years
Brand (Posted: Mar 03, 2017 8AM)

Autoimmunity in Guillain-Barré syndrome associated with Zika virus infection and beyond.
Pinto-Díaz Carlos A et al. Autoimmunity reviews 2017 Feb (Posted: Mar 01, 2017 8PM)

Persistence of Zika Virus in Body Fluids — Preliminary Report
G Paz-Bailey et al, NEJM, February 14, 2017 (Posted: Feb 15, 2017 5PM)

Zika Virus Infection as a Cause of Congenital Brain Abnormalities and Guillain–Barré Syndrome: Systematic Review
F Krauer et al, PLOS Medicine, January 3, 2017 (Posted: Jan 04, 2017 9AM)

Zika Virus —10 Public Health Achievements in 2016 and Future Prioriti
CDC MMWR, December 30, 2016 Brand (Posted: Dec 30, 2016 1PM)

Preliminary Report of Microcephaly Potentially Associated with Zika Virus Infection During Pregnancy — Colombia, January–November 2016
MMWR. December 9, 2016 (Posted: Dec 12, 2016 8AM)

ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis.
Gupta Amit Kumar et al. Scientific reports 2016 Sep 32713 (Posted: Nov 01, 2016 9AM)

What You Need to Know
Brand (Posted: Nov 01, 2016 9AM)

Zika and Guillain-Barré Syndrome
(Posted: Oct 03, 2016 10AM)

Considerations for Developing a Zika Virus Vaccine
HD Marston et al, NEJM, September 29, 2016 (Posted: Sep 30, 2016 8AM)

Fast-Track Zika Vaccine Development — Is It Possible?
SJ Thomas et al, NEJM, September 29, 2016 (Posted: Sep 30, 2016 8AM)

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors.
Zhang Feiran et al. Nucleic acids research 2016 Aug (Posted: Sep 20, 2016 0PM)

Zika Virus Infection in Pregnancy, Microcephaly, and Maternal and Fetal Health: What We Think, What We Know, and What We Think We Know.
Alvarado Maria Gabriela et al. Archives of pathology & laboratory medicine 2016 Sep (Posted: Sep 20, 2016 0PM)

One year of Zika in Brazil: what have we learned?
LS Faccini, PHG Foundation, September 14, 2016 (Posted: Sep 14, 2016 6AM)

Pregnant Women: How to protect yourself
Brand (Posted: Aug 23, 2016 1PM)

Complete Genome Sequences of Three Historically Important, Spatiotemporally Distinct, and Genetically Divergent Strains of Zika Virus: MR-766, P6-740, and PRVABC-59.
Yun Sang-Im et al. Genome announcements 2016 (4) (Posted: Aug 22, 2016 5PM)

Prolonged Detection of Zika Virus RNA in Pregnant Women.
Meaney-Delman Dana et al. Obstetrics and gynecology 2016 Jul (Posted: Aug 22, 2016 5PM)

Zika Virus 6 Months Later
TR Frieden et al, JAMA, August 9, 2016 (Posted: Aug 09, 2016 6PM)

CDC awards $16 million to states and territories to fight Zika
CDC Press Release, August 2016 Brand (Posted: Aug 08, 2016 1PM)

3 Zika tests explained
A Gaynor, APHL Blog Post, August 5, 2016 (Posted: Aug 08, 2016 10AM)

The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact.
Boeuf Phillipe et al. BMC medicine 2016 (1) 112 (Posted: Aug 08, 2016 10AM)

A second look: Efforts to repurpose old drugs against Zika cast a wide net.
Kincaid Ellie et al. Nature medicine 2016 Aug (8) 824-5 (Posted: Aug 08, 2016 10AM)

Complete Genome Sequence of Zika Virus Isolated in Mexico, 2016.
Díaz-Quiñonez José Alberto et al. Genome announcements 2016 (4) (Posted: Aug 08, 2016 10AM)

INFECTIOUS DISEASE. Zika vaccine has a good shot.
Cohen Jon et al. Science (New York, N.Y.) 2016 Aug (6299) 529-30 (Posted: Aug 08, 2016 10AM)

Detection of Zika virus in Brazilian patients during the first five days of infection - urine versus plasma.
Pessôa Rodrigo et al. Euro surveillance : bulletin Europe´en sur les maladies transmissibles = European communicable disease bulletin 2016 Jul (30) (Posted: Aug 08, 2016 10AM)

Zika meets its match
AK Shalek, Science Translational Medicine, July 13, 2016 (Posted: Jul 15, 2016 2PM)

Zika Vaccine: Two Candidates Show Promise in Mice
Francis Collins, NIH Director Blog, July 5, 2016 Brand (Posted: Jul 05, 2016 2PM)

Genomics in the battle against Zika virus
Genomics Education Program UK, June 21, 2016 (Posted: Jun 21, 2016 6AM)

Mobile laboratories help track Zika spread across Brazil
University of Birminghman Blog, June 8, 2016 (Posted: Jun 08, 2016 8AM)

The mitotic spindle: linking teratogenic effects of Zika virus with human genetics?
Bullerdiek Joern et al. Molecular cytogenetics 2016 32 (Posted: May 31, 2016 0PM)

Neurodevelopmental disorders: Risks of Zika virus during the first trimester of pregnancy.
Molnár Zoltán et al. Nature reviews. Neurology 2016 May (Posted: May 31, 2016 0PM)

Genomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology.
Rasmussen Angela L et al. Cell host & microbe 2016 May (5) 611-8 (Posted: May 31, 2016 0PM)

Alternative vector control methods to manage the Zika virus outbreak: more haste, less speed.
Boëte Christophe et al. The Lancet. Global health 2016 Jun (6) e363 (Posted: May 31, 2016 0PM)

Scientists clone Zika for vaccine race
BBC News, May 16, 2016 (Posted: May 16, 2016 7PM)

Why transgenic insects are still not ready for prime time
RJ Loped, Nature, April 22, 2016 (Posted: Apr 22, 2016 2PM)

Teratogenic effects of the Zika virus and the role of the placenta.
Adibi Jennifer J et al. Lancet (London, England) 2016 Mar (Posted: Apr 01, 2016 2PM)

Zika Virus Associated with Microcephaly.
Mlakar Jernej et al. The New England journal of medicine 2016 Mar (10) 951-8 (Posted: Apr 01, 2016 2PM)

Zika Virus and Microcephaly.
Rubin Eric J et al. The New England journal of medicine 2016 Mar (10) 984-5 (Posted: Apr 01, 2016 2PM)

Zika virus genome from the Americas.
Enfissi Antoine et al. Lancet (London, England) 2016 Jan (10015) 227-8 (Posted: Apr 01, 2016 2PM)

First Complete Genome Sequence of Zika Virus (Flaviviridae, Flavivirus) from an Autochthonous Transmission in Brazil.
Cunha Mariana Sequetin et al. Genome announcements 2016 (2) (Posted: Apr 01, 2016 2PM)

Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study.
Calvet Guilherme et al. The Lancet. Infectious diseases 2016 Feb (Posted: Apr 01, 2016 2PM)

Zika virus disease in the United States, 2015–2016
Brand (Posted: Apr 01, 2016 2PM)

Zika Action Plan Summit
Brand (Posted: Apr 01, 2016 2PM)

Diagnostic Testing
Brand (Posted: Apr 01, 2016 2PM)

CDC Concludes Zika Causes Microcephaly and Other Birth Defects
Brand (Posted: Mar 10, 2016 0AM)

Zika Virus and Birth Defects — Reviewing the Evidence for Causality
SA Rasmussen et al. NEJM, April 13, 2016 (Posted: Mar 10, 2016 0AM)

Characterizing the Zika virus genome - A bioinformatics study.
Nandy Ashesh et al. Current computer-aided drug design 2016 Apr (Posted: Mar 10, 2016 0AM)

Tweaking Genes to Save Species
H Rosner, New York Times, April 16, 2016 (Posted: Mar 10, 2016 0AM)

From Ebola to Zika, tiny mobile lab gives real-time DNA data on outbreaks
The Guardian, February 3, 2016 (Posted: Feb 01, 2016 0AM)

AMD in Action: CDC Scientists Use AMD Methods to Develop Diagnostic Tools for Zika Virus
Brand (Posted: Feb 01, 2016 0AM)

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Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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