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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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13 hot topic(s) found with the query "Osteoarthritis"

Smartphone videos of the sit-to-stand test predict osteoarthritis and health outcomes in a nationwide study
MA Boswell et al, NPJ Digital Medicine, March 4, 2023 (Posted: Mar 04, 2023 9AM)

Physical function decline due to aging or disease can be assessed with quantitative motion analysis, but this currently requires expensive laboratory equipment. We introduce a self-guided quantitative motion analysis of the widely used five-repetition sit-to-stand test using a smartphone. Across 35 US states, 405 participants recorded a video performing the test in their homes. We found that the quantitative movement parameters extracted from the smartphone videos were related to a diagnosis of osteoarthritis, physical and mental health, body mass index, age, and ethnicity and race.

Targeted therapy for osteoarthritis: progress and pitfalls.
Schäfer Nicole et al. Nature medicine 2022 12 (Posted: Dec 02, 2022 6AM)

Osteoarthritis is highly heterogeneous, so effective therapies will need to target clearly defined molecular endotypes, restore mechanical joint function and reduce pain; thus, a ‘one-size-fits-all’ approach is unlikely to succeed.

Novel genetic loci associated with osteoarthritis in multi-ancestry analyses in the Million Veteran Program and UK Biobank.
McDonald Merry-Lynn N et al. Nature genetics 2022 11 (Posted: Nov 22, 2022 7AM)

We used the unique resources of 484,374 participants in the Million Veteran Program and UK Biobank to address this gap. Analyses included participants of European, African, Asian and Hispanic descent. We discovered osteoarthritis-associated genetic variation at 10 loci and replicated findings from previous osteoarthritis studies. We also present evidence that some osteoarthritis-associated regions are robust to population ancestry. Drug repurposing analyses revealed enrichment of targets of several medication classes and provide insight into the etiology of beneficial effects of antiepileptics on osteoarthritis pain.

Comparison of an Artificial Intelligence–Enabled Patient Decision Aid vs Educational Material on Decision Quality, Shared Decision-Making, Patient Experience, and Functional Outcomes in Adults With Knee Osteoarthritis A Randomized Clinical Trial
P Jayakumar et al, JAMA Network Open, February 2021 (Posted: Mar 02, 2021 8AM)

This randomized clinical trial of 129 patients demonstrated statistically significant improvement in decision quality, level of shared decision-making, patient satisfaction, and functional outcomes in patients using an AI-enabled decision aid.

Comparison of an Artificial Intelligence-Enabled Patient Decision Aid vs Educational Material on Decision Quality, Shared Decision-Making, Patient Experience, and Functional Outcomes in Adults With Knee Osteoarthritis: A Randomized Clinical Trial.
Jayakumar Prakash et al. JAMA network open 2021 Feb 4(2) e2037107 (Posted: Feb 23, 2021 9AM)

This randomized clinical trial at a single US academic orthopedic practice included 129 new adult patients presenting for OA-related knee pain from March 2019 to January 2020. Data were analyzed from April to May 2020.Patients were randomized into a group that received a decision aid including patient education, preference assessment, and personalized outcome estimations (intervention group) or a group receiving educational material only (control group) alongside usual care.

Cardiometabolic polygenic risk scores and osteoarthritis outcomes: a Mendelian randomization study from the MalmÓ§ Diet and Cancer Study and the UK Biobank.
Hindy George et al. Arthritis & rheumatology (Hoboken, N.J.) 2019 Jan (Posted: Jan 09, 2019 9AM)

Diagnosis of Osteoarthritis Subtypes with Blood Biomarkers
K Zhao et al, BioRXIV, July 10, 2018 (Posted: Jul 16, 2018 8AM)

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis
E Zengini et al, Nature Genet, Mar 20, 2018 (Posted: Mar 20, 2018 0PM)

Osteoarthritis year in review 2016: genetics, genomics and epigenetics.
van Meurs J B J et al. Osteoarthritis and cartilage 2017 Feb (2) 181-189 (Posted: Aug 11, 2017 1PM)

The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping.
Eyre Stephen et al. Nature reviews. Rheumatology 2017 Jul (7) 421-432 (Posted: Aug 11, 2017 1PM)

The genetic architecture of osteoarthritis: insights from UK Biobank
E Zengini et al, BioRXiV, AUgust 2017 (Posted: Aug 11, 2017 1PM)

Inflammation and epigenetic regulation in osteoarthritis.
Shen Jie et al. Connective tissue research 2016 Jul (Posted: Jul 15, 2016 11AM)

Applying computation biology and "big data" to develop multiplex diagnostics for complex chronic diseases such as osteoarthritis.
Ren Guomin et al. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2016 Jan 1-7 (Posted: Feb 08, 2016 8PM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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