
Archive
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
Sign up MyPHGKB to receive the daily hot topic email alert.
Archived Hot Topics of the Day By Date
Germline mismatch repair (MMR) gene analyses from English NHS regional molecular genomics laboratories 1996-2020: development of a national resource of patient-level genomics laboratory records.
Loong Lucy et al. Journal of medical genetics 2022 12
(Posted: Jan-04-2023 6AM)
Comparison of Germline Genetic Testing Before and After a Medical Policy Covering Universal Testing Among Patients With Colorectal Cancer
C Moretz et al, JAMA Network Open, October 24, 2022
(Posted: Oct-24-2022 0PM)
Relatives from Hereditary Breast and Ovarian Cancer and Lynch Syndrome Families Forgoing Genetic Testing: Findings from the Swiss CASCADE Cohort
M Sarki et al, J Per Med, October 19, 2022
(Posted: Oct-20-2022 8AM)
Proband-mediated interventions to increase disclosure of genetic risk in families with a BRCA or Lynch syndrome condition: a systematic review
AL Young et al, EJHG, October 17, 2022
(Posted: Oct-17-2022 7AM)
Genetic Testing Challenges in Oncology: Lynch Syndrome Diagnosis Despite Negative Test Results
T Ray, Precision Oncology News, August 29, 2022
(Posted: Aug-30-2022 9AM)
Bowel cancer: what role do our genes play?
Genetics Education Program, August 19, 2022
(Posted: Aug-21-2022 3PM)
Risk factors for gastric cancer in patients with Lynch syndrome.
Ortigão Raquel et al. European journal of gastroenterology & hepatology 2022 7
(Posted: Jul-20-2022 7AM)
Incomplete Penetrance of Population-Based Genetic Screening Results in Electronic Health Record
G Elhanan et al, Frontiers in Genetics, April 2022
(Posted: May-26-2022 7AM)
Paired Tumor-Germline Testing as a Driver in Better Cancer Care
JW Henson et al, JAMA Network Open, May 20, 2022
(Posted: May-21-2022 2PM)
Lynch syndrome; towards more personalized management?
J Llach et al, Best Practice & Research Clinical Gastroenterology, March 2022
(Posted: Apr-20-2022 9AM)
New generation of cancer-preventing vaccines could wipe out tumors before they form
J Kaiser, Science, April 7, 2022
(Posted: Apr-09-2022 1PM)
Cost-effectiveness of population-wide genomic screening for Lynch syndrome in the United States.
Guzauskas Gregory F et al. Genetics in medicine : official journal of the American College of Medical Genetics 2022
(Posted: Mar-05-2022 7AM)
Lynch Syndrome
FORCE, February 2022
(Posted: Feb-20-2022 7AM)
Lynch Syndrome: A Common Yet Under-Recognized Hereditary Cancer Predisposition
Lynch Syndrome Ireland, February 1, 2022
(Posted: Feb-01-2022 7AM)
A Mini-Symposium: Implementing Precision and Equitable Public Health in Cascade Testing for Genetic Disorders
CDC event, Feb 10, 2022
(Posted: Dec-13-2021 2PM)
30 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes
ER Woodward et al, EJHG, December 6, 2021
(Posted: Dec-06-2021 6AM)
Up-Front Multigene Panel Testing for Cancer Susceptibility in Patients With Newly Diagnosed Endometrial Cancer: A Multicenter Prospective Study
MD Levine et al, JCO Precision Oncology, October 2021
(Posted: Dec-02-2021 8AM)
Should Children Be Tested for Hereditary Cancer Syndromes?
G Hurst, Cure magazine, November 8, 2021
(Posted: Nov-09-2021 6AM)
National Hereditary Cancer Week 2021
FORCE, September 2021
(Posted: Sep-29-2021 10AM)
Should women with Lynch syndrome be offered gynaecological cancer surveillance?
NAJ Ryan, BMJ, September 2, 2021
(Posted: Sep-03-2021 7AM)
Health Equity and Genetic Disorders
CDC, August 2021
(Posted: Sep-01-2021 7AM)
Living with Lynch Syndrome: Pick Your Hard
G Hurst, Cure, August 31, 2021
(Posted: Sep-01-2021 7AM)
PMS2 is the most frequently mutated Lynch syndrome (LS) gene in women with endometrial cancer (EC): what is the role that low penetrance LS genes play in EC?
M Levine et al, Obs Gyn, August 2021
(Posted: Aug-22-2021 7AM)
Vaccine to Prevent Hereditary Cancers Nears Human Trials
S Jenks, NCI Blog, July 2021
(Posted: Jul-18-2021 7AM)
Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention Initiative.
Pearlman Rachel et al. JCO precision oncology 2021 7
(Posted: Jul-14-2021 6AM)
Expanding Germline Testing to All Patients With Esophagogastric Cancers—Easy to Do, Harder to Justify
JAMA Network Open, July 12, 2021
(Posted: Jul-13-2021 7AM)
Primary care providers’ responses to unsolicited Lynch syndrome secondary findings of varying clinical significance
LN Galbraith et al, Genet in Med, June 10, 2021
(Posted: Jun-11-2021 7AM)
Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study
The International Mismatch Repair Consortium, The Lancet Oncology, June 7, 2021
(Posted: Jun-09-2021 7AM)
Stakeholders’ views of integrating universal tumour screening and genetic testing for colorectal and endometrial cancer into routine oncology
ER O'Shea et al, JHG, April 2021
(Posted: Apr-03-2021 7AM)
Interventions Facilitating Family Communication of Genetic Testing Results and Cascade Screening in Hereditary Breast/Ovarian Cancer or Lynch Syndrome: A Systematic Review and Meta-Analysis.
Baroutsou Vasiliki et al. Cancers 2021 13(4)
(Posted: Mar-09-2021 9AM)
Room for improvement: One third of Lynch syndrome patients presenting for genetic testing in a highly specialised centre in Stockholm already have cancer.
Bernstedt Sophie Walton et al. Hereditary cancer in clinical practice 2021 Feb 19(1) 18
(Posted: Feb-16-2021 9AM)
New Technique Identifies Important Mutations Behind Lynch Syndrome - Approach could improve predictive value of genetic screening.
K Malcom, University of Michigan, January 27, 2021
(Posted: Jan-29-2021 8AM)
Acquired somatic MMR deficiency is a major cause of MSI tumor in patients suspected for “Lynch-like syndrome” including young patients
S Lefol et al, EJHG, December 5, 2020
(Posted: Dec-07-2020 8AM)
Pembrolizumab in MSI-H–dMMR Advanced Colorectal Cancer — A New Standard of Care
A Grothey, NEJM, December 2, 2020
(Posted: Dec-03-2020 7AM)
Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
MD Valentin et al, Genetics in Medicine, December 1, 2020
(Posted: Dec-01-2020 8AM)
Endometrial Cancer.
Lu Karen H et al. The New England journal of medicine 2020 Nov (21) 2053-2064
(Posted: Nov-20-2020 8AM)
Testing strategies for Lynch syndrome in people with endometrial cancer
NICE, October 28, 2020
(Posted: Oct-28-2020 9AM)
Germline Testing for Lynch Syndrome: More Important Than Ever
B Cote, Onc Nursing News, October 2020
(Posted: Oct-12-2020 7AM)
Diagnostics of Mutations in MMR/EPCAM Genes and Their Role in the Treatment and Care of Patients with Lynch Syndrome
J Sobocinka et al, MDPI Diagnostics, October 2020
(Posted: Oct-12-2020 7AM)
Implementing Cancer Genomics in State Health Agencies: Mapping Activities to an Implementation Science Outcome Framework.
Green Ridgely Fisk et al. Public health genomics 2020 Sep 1-12
(Posted: Sep-18-2020 9AM)
Refining risk-estimates in HNPCC: are we there yet?
PM ynch et al, JNCI Cancer Spectrum, 2020
(Posted: Sep-08-2020 11AM)
LIVING WITH LYNCH 2020- Virtual Patient Workshop
Alive and Kicking and Colon Cancer Foundation Webinar October 9, 2020
(Posted: Aug-21-2020 9AM)
Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions
AC Fahed et al, Nature Communications, August 20, 2020
(Posted: Aug-21-2020 9AM)
Strategies to Identify and Care for Individuals with Inherited Cancer Syndromes
NCI Webinar, July 30, 2020
(Posted: Jul-07-2020 10AM)
Clinical outcomes of a genomic screening program for actionable genetic conditions
AH Buchanan et al, Genetics in Medicine, June 30, 2020
(Posted: Jul-01-2020 8AM)
Aspirin for Lynch syndrome: a legacy of prevention
MB Yurgelun et al, The Lancet, June 13, 2020
(Posted: Jun-13-2020 7AM)
Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial
J Burn et al, The Lancet June 13, 2020
(Posted: Jun-13-2020 7AM)
Comparison of two Lynch screening strategies in endometrial cancer in a California health system.
Lentz Scott E et al. Gynecologic oncology 2020 May
(Posted: May-12-2020 4PM)
Adequacy evaluation of the annual colonoscopic surveillance and individual difference of disease phenotypes in Lynch syndrome.
Taniguchi Fumitaka et al. Japanese journal of clinical oncology 2020 May
(Posted: May-12-2020 4PM)
Association of Rare Pathogenic DNA Variants for Familial Hypercholesterolemia, Hereditary Breast and Ovarian Cancer Syndrome, and Lynch Syndrome With Disease Risk in Adults According to Family History
AP Patel, JAMA Network Open, April 29, 2020
(Posted: Apr-30-2020 8AM)
Investigating the Link between Lynch Syndrome and Breast Cancer.
Sheehan Megan et al. European journal of breast health 2020 Apr 16(2) 106-109
(Posted: Apr-22-2020 9AM)
Associations Between Mutations in MSH6 and PMS2 and Risk of Surveillance-detected Colorectal Cancer.
Lamba Mehul et al. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020 Mar
(Posted: Apr-08-2020 9AM)
The Prospective Lynch Syndrome Database reports enable evidence-based personal precision health care.
Møller Pål et al. Hereditary cancer in clinical practice 2020 186
(Posted: Mar-25-2020 9AM)
My genes are stacked against me; it's made me a fighter
A Leippi, CBC News, January 22, 2020
(Posted: Jan-23-2020 11AM)
Celebrating the career and contributions of Dr Henry T. Lynch (1928-2019).
Butel-Simoes Grace I et al. Internal medicine journal 2020 Jan 50(1) 108-109
(Posted: Jan-22-2020 9AM)
Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome.
Engel Christoph et al. Gastroenterology 2020 Jan
(Posted: Jan-15-2020 8AM)
Mayo genomic database to use sequencing for 100K participants
G Slabodkin, Health Data Management, January 10, 2020
(Posted: Jan-13-2020 9AM)
Benefit from extended surveillance interval on colorectal cancer risk in Lynch syndrome.
Lindberg Lars Joachim et al. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2019 Dec
(Posted: Jan-02-2020 10AM)
Extent of Pedigree Required to Screen for and Diagnose Hereditary Nonpolyposis Colorectal Cancer: Comparison of Simplified and Extended Pedigrees.
Heo Yoonjung et al. Diseases of the colon and rectum 2019 Dec
(Posted: Dec-18-2019 8AM)
Targeted deep-intronic sequencing in a cohort of unexplained cases of suspected Lynch syndrome.
Arnold Anke Marie et al. European journal of human genetics : EJHG 2019 Dec
(Posted: Dec-12-2019 9AM)
Low Rates of Genetic Counseling and Testing in Individuals at Risk for Lynch Syndrome reported in the National Health Interview Survey.
Faust Nolan et al. Gastroenterology 2019 Dec
(Posted: Dec-11-2019 9AM)
Implementing universal cancer screening programs can help sustain genomic medicine programs
AK Rahm et al, Frontiers in Genetics, December 2019
(Posted: Dec-11-2019 7AM)
The Current Practice of Lynch Syndrome Diagnosis and Management in Italy: A Qualitative Assessment.
Tognetto Alessia et al. Public health genomics 2019 Dec 1-19
(Posted: Dec-07-2019 7AM)
Low rates of cascade genetic testing among families with hereditary gynecologic cancer: An opportunity to improve cancer prevention.
Griffin Natalie E et al. Gynecologic oncology 2019 Nov
(Posted: Dec-04-2019 10AM)
Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG).
Monahan Kevin J et al. Gut 2019 Nov
(Posted: Dec-04-2019 9AM)
People with genetic condition should be given aspirin daily to slash their risk of colorectal cancer
Denton Daily, November 24, 2019
(Posted: Nov-25-2019 8AM)
Guidelines for the management of hereditary colorectal cancer from the BSG /ACPGBI/UKCGG
British Society Gastroenterology, October 2019
(Posted: Nov-10-2019 8AM)
Cost-effectiveness of Active Identification and Subsequent Colonoscopy Surveillance of Lynch Syndrome Cases.
Peterse Elisabeth F P et al. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2019 Oct
(Posted: Oct-23-2019 9AM)
Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report
MD Valentin et al, Hereditary Cancer in Clinical Practice, October 2019
(Posted: Oct-23-2019 8AM)
The predicted impact and cost-effectiveness of systematic testing of people with incident colorectal cancer for Lynch syndrome.
Kang Yoon-Jung et al. The Medical journal of Australia 2019 Oct
(Posted: Oct-16-2019 9AM)
A Patient’s Guide to Endometrial Cancer-This cancer is on the rise. But early detection saves lives.
MO Shroeder, US News, October 4, 2019
(Posted: Oct-05-2019 9AM)
Can an Aspirin a Day Prevent Colorectal Cancer in People with Lynch Syndrome?
S Bowen et al, CDC Blog, October 2, 2019
(Posted: Oct-04-2019 10AM)
For women Lynch syndrome is about more than colon cancer.
Parker Wendy M et al. Cancer prevention research (Philadelphia, Pa.) 2019 Sep
(Posted: Oct-02-2019 8AM)
Sir John Burn Delivers Seminar on Prediction and Prevention of Colorectal Cancer in Patients with Lynch Syndrome
NCI,September 26, 2019
(Posted: Sep-28-2019 8AM)
Implementation science and genomic medicine in action: A case study
M Clyne et al, CDC Blog, September 18, 2019
(Posted: Sep-19-2019 9AM)
White-light Endoscopy is Adequate for Lynch Syndrome Surveillance in a Randomized and Non-inferiority Study.
Rivero-Sánchez Liseth et al. Gastroenterology 2019 Sep
(Posted: Sep-18-2019 10AM)
What you need to know about ovarian cancer
CDC, 2019
(Posted: Sep-05-2019 8AM)
New Data Reveal that Expanding Genetic Testing Guidelines Could Identify More Patients with Increased Risks of Cancer
A Viejo, PRWeb, August 27, 2019
(Posted: Aug-28-2019 7AM)
Implementing Universal Lynch Syndrome Screening across Multiple Healthcare Systems: Identifying Strategies to Facilitate and Maintain Programs in Different Organizational Contexts
NCI, August 2019
(Posted: Aug-23-2019 11AM)
Rationale for evaluating breast cancers of Lynch syndrome patients for mismatch repair gene expression.
Sorscher Steven et al. Breast cancer research and treatment 2019 Aug
(Posted: Aug-14-2019 8AM)
A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients
H LaDuca et al, Genetics in Medicine, August 13, 2019
(Posted: Aug-13-2019 9AM)
Offer daily aspirin to those with inherited genetic condition to reduce the risk of colorectal cancer
NICE, August 2, 2019
(Posted: Aug-03-2019 4PM)
Daily aspirin reduces bowel cancer risk in people with Lynch syndrome, says NICE
Cancer Research UK, August 2, 2019
(Posted: Aug-03-2019 4PM)
Family still matters: Counseling patients with complex family histories of colon and endometrial cancers.
Gemmell Amber P et al. Molecular genetics & genomic medicine 2019 Jul e886
(Posted: Jul-31-2019 8AM)
Next Generation Sequencing Reveals Novel Mutations in Mismatch Repair Genes and Other Cancer Predisposition Genes in Asian Patients with Suspected Lynch Syndrome.
Ow Samuel G W et al. Clinical colorectal cancer 2019 Jun
(Posted: Jul-31-2019 8AM)
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.
Dominguez-Valentin Mev et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Jul
(Posted: Jul-26-2019 9AM)
Lynch Syndrome Screening in Gynecological Cancers: Results of an International Survey with Recommendations for Uniform Reporting Terminology for Mismatch Repair Immunohistochemistry Results.
Ryan Neil et al. Histopathology 2019 Jul
(Posted: Jul-24-2019 10AM)
The 2019 HBOC and Lynch Syndrome Family Day
Michigan Public Health Institute, Register for event, September 21, 2019
(Posted: Jul-12-2019 8AM)
Suboptimal Adherence in Clinical Practice to Guidelines Recommendation to Screen for Lynch Syndrome.
Jain A et al. Digestive diseases and sciences 2019 Jun
(Posted: Jun-19-2019 9AM)
Henry Lynch, celebrated as father of cancer genetics, dies at 91
E Langer, Washington Post, June 4, 2019
(Posted: Jun-05-2019 10AM)
Deficient mismatch repair testing in colorectal cancer: more than just screening for Lynch syndrome.
West N P et al. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2019 Jun 21(6) 621-622
(Posted: Jun-05-2019 10AM)
Universal endometrial cancer tumor typing: How much has immunohistochemistry, microsatellite instability, and MLH1 methylation improved the diagnosis of Lynch syndrome across the population?
Kahn Ryan M et al. Cancer 2019 May
(Posted: Jun-05-2019 9AM)
Dr. Henry Lynch dies at 91
KETV, June 3, 2019
(Posted: Jun-04-2019 8AM)
Tribute to Dr Lynch
Lynch Syndrome International. June 2019
(Posted: Jun-03-2019 10AM)
Universal tumor screening for Lynch syndrome: Perceptions of Canadian pathologists and genetic counselors of barriers and facilitators.
Dicks Elizabeth et al. Cancer medicine 2019 May
(Posted: May-22-2019 8AM)
The proportion of endometrial cancers associated with Lynch syndrome: a systematic review of the literature and meta-analysis
NAJ Ryan et al, Genetics in Medicine, May 14, 2019
(Posted: May-14-2019 2PM)
A Positive Outlook for Lynch Syndrome-Related Cancers
B Benyon, Oncology Nursing News, May 11, 2019
(Posted: May-13-2019 8AM)
Targeted Cancer Next Generation Sequencing as a Primary Screening Tool for Microsatellite Instability and Lynch Syndrome in Upper Gastrointestinal Tract Cancers.
Christakis Alexander G et al. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2019 Apr
(Posted: May-05-2019 11AM)
Health and lifestyle behaviors in colorectal cancer survivors with and without Lynch syndrome.
Donato Kirsten M et al. Journal of community genetics 2019 Apr
(Posted: May-01-2019 9AM)
Effect of chromoendoscopy in the proximal colon on colorectal neoplasia detection in Lynch syndrome: a multicenter randomized controlled trial.
Haanstra Jasmijn F et al. Gastrointestinal endoscopy 2019 Apr
(Posted: May-01-2019 9AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Jul 25, 2022
- Page last updated:Jan 30, 2023
- Content source: