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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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50 hot topic(s) found with the query "Glaucoma"

Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care
J Zhang et al, Nat Comms, September 20, 2022 (Posted: Sep 21, 2022 7AM)

Preventing Glaucoma Vision Loss with ‘Big Data’
F Collins, NIH Director blog, September 16, 2021 (Posted: Sep 17, 2021 6AM)

A recent study analyzed data from more than 1,200 people with glaucoma who participate in NIH’s All of Us Research Program. With consent from the participants, Baxter used their EHRs to train a computer to find telltale patterns within the data and then predict with 80 to 99 percent accuracy who would later require eye surgery.

Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma
OM Siggs et al, JAMA INt Med, July 2021 (Posted: Jul 20, 2021 7AM)

In this cross-sectional study of 2507 individuals with open-angle glaucoma, high polygenic risk was associated with risk of developing glaucoma comparable with the risk associated with the most common single-gene pathogenic variant, but was more than 15 times more prevalent in the general population than this single-gene variant.

Glaucoma in Adults-Screening, Diagnosis, and Management: A Review.
Stein Joshua D et al. JAMA 2021 Jan (2) 164-174 (Posted: Jan 13, 2021 9AM)

Glaucoma is a chronic progressive optic neuropathy, characterized by damage to the optic nerve and retinal nerve fiber layer, that can lead to permanent loss of peripheral or central vision. Intraocular pressure is the only known modifiable risk factor. Other important risk factors include older age, nonwhite race, and a family history of glaucoma.

Predicting the Future of Genetic Risk Profiling of Glaucoma: A Narrative Review.
Han Xikun et al. JAMA ophthalmology 2020 Dec (Posted: Dec 18, 2020 8AM)

Advances in glaucoma genetics have opened the door for risk stratification based on genetic risk predictions. The polygenic risk score approach has shown good promise in predicting who will be at highest risk of glaucoma, which could improve outcomes if these predictions can be acted on to result in improved clinical outcomes.

Development and clinical deployment of a smartphone-based visual field deep learning system for glaucoma detection
F Li et al, NPJ Digital Medicine, September 22, 2020 (Posted: Sep 22, 2020 10AM)

By 2040, ~100 million people will have glaucoma. To date, there are a lack of high-efficiency glaucoma diagnostic tools based on visual fields (VFs). Herein, we develop and evaluate the performance of ‘iGlaucoma’, a smartphone application-based deep learning system (DLS) in detecting glaucomatous VF changes.

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.
Craig Jamie E et al. Nature genetics 2020 Jan (Posted: Jan 23, 2020 11AM)

Glaucoma, characterized by progressive optic nerve degeneration, can be prevented through timely diagnosis and treatment. We characterize optic nerve photographs of 67,040 UK Biobank participants and use a multitrait genetic model to identify risk loci for glaucoma. A glaucoma polygenic risk score enables effective risk stratification in unselected glaucoma cases.

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry
JAMA Network Open, November 7, 2019 (Posted: Nov 08, 2019 9AM)

In this multistage, case-control, genome-wide association study that included 26?295 participants, the amyloid-ß A4 precursor protein-binding family B member 2 (APBB2) locus was significantly associated with primary open-angle glaucoma among individuals of African ancestry.

Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis.
Fan Bao Jian et al. JAMA ophthalmology 2019 Aug (Posted: Aug 23, 2019 8AM)

A higher polygenic risk score was associated with an earlier age at glaucoma diagnosis. On average, individuals with POAG with the highest PRS had 5.2-year earlier age at diagnosis of disease. PRS could help identify patients with risk of earlier disease onset impacting screening and therapeutic strategies.

Don't lose sight of glaucoma
NEI, January 2019 Brand (Posted: Jan 08, 2019 0PM)

Familial Risks of Glaucoma in the Population of Sweden.
Li Xinjun et al. Journal of glaucoma 2018 Jun (Posted: Jul 03, 2018 11AM)

Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma
AP Khawaja et al, Nature Genetics, May 21, 2018 (Posted: May 21, 2018 2PM)

Heritability of glaucoma and glaucoma-related endophenotypes: systematic review and meta-analysis protocol.
Asefa Nigus Gebrmedhin et al. BMJ open 2018 02 (2) e019049 (Posted: Mar 11, 2018 0PM)

Genetic Basis Uncovered for Glaucoma
W Doss, Northwestern University, Jan 29, 2018 (Posted: Jan 30, 2018 0PM)

Eradicating primary congenital glaucoma from Saudi Arabia: The case for a national screening program.
Malik Rizwan et al. Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society 31(4) 247-249 (Posted: Dec 20, 2017 0PM)

Epigenetics and Signaling Pathways in Glaucoma.
Gauthier Angela C et al. BioMed research international 2017 5712341 (Posted: Mar 13, 2017 8AM)

Genetics and genetic testing for glaucoma.
Miller Matthew A et al. Current opinion in ophthalmology 2017 Mar (2) 133-138 (Posted: Mar 13, 2017 8AM)

Don't Let Glaucoma Steal Your Sight!
Family history is a risk factor Brand (Posted: Jan 12, 2017 8PM)

Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma
CC Khor et al, Nature Genetics, April 3, 2016 (Posted: Apr 06, 2016 9AM)

Researchers Find 3 More Glaucoma-Related Genes
JA Jacob, JAMA, February 25, 2016 (Posted: Feb 26, 2016 8AM)

The Genetics and the Genomics of Primary Congenital Glaucoma.
Cascella Raffaella et al. BioMed research international 2015 321291 (Posted: Jan 20, 2016 9AM)

Primary Open-Angle Glaucoma in Individuals of African Descent: A Review of Risk Factors.
Salowe Rebecca et al. Journal of clinical & experimental ophthalmology 2015 Aug (4) (Posted: Jan 20, 2016 9AM)

An Updated Review on the Genetics of Primary Open Angle Glaucoma.
Abu-Amero Khaled et al. International journal of molecular sciences 2015 (12) 28886-911 (Posted: Jan 20, 2016 9AM)

Glaucoma
Mayo Clinic (Posted: Jan 20, 2016 9AM)

Glaucoma: Causes and Risk Factors include family history
NIH Senior Health (Posted: Jan 20, 2016 9AM)

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma
JN Cooke Baily et al, Nature Genetics, January 11, 2016 (Posted: Jan 11, 2016 2PM)

Genetics and Early Onset Glaucoma
NIH Genetics Home Reference Brand (Posted: Jan 08, 2016 1PM)

Common Molecular Challenges in Glaucoma.
Sarfarazi Mansoor et al. Journal of ophthalmic & vision research (2) 95-7 (Posted: Jan 08, 2016 1PM)

Advances in glaucoma genetics.
Sakurada Yoichi et al. Progress in brain research 2015 107-26 (Posted: Jan 08, 2016 1PM)

Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants.
Sundaresan Periasamy et al. Genet. Med. 2014 Sep 18. (Posted: Apr 03, 2015 10AM)

Sleep Apnea
From NHLBI health topic site Brand (Posted: Jan 01, 2014 0AM)

Sleep apnea is a common condition in the United States. It can occur when the upper airway becomes blocked repeatedly during sleep, reducing or completely stopping airflow. This is known as obstructive sleep apnea. If the brain does not send the signals needed to breathe, the condition may be called central sleep apnea. Healthcare providers use sleep studies to diagnose sleep apnea. They record the number of episodes of slow or stopped breathing and the number of central sleep apnea events detected in an hour. They also determine whether oxygen levels in the blood are lower during these events. Breathing devices such as continuous positive air pressure (CPAP) machines and lifestyle changes are common sleep apnea treatments. Undiagnosed or untreated sleep apnea can lead to serious complications such as heart attack, glaucoma, diabetes, cancer, and cognitive and behavioral disorders. Explore this Health Topic to learn more about sleep apnea, our role in research and clinical trials to improve health, and where to find more information.

Retinal degeneration with nanophthalmos, cystic macular degeneration, and angle closure glaucoma
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Cataract-glaucoma
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Dyssegmental dysplasia and glaucoma
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Glaucoma, Ectopia, Microspherophakia, Stiff joints and Short stature syndrome
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Glaucoma iridogoniodysgenesia
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Glaucoma sleep apnea
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Glaucoma type 1C
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Glaucoma, congenital
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Glaucoma, hereditary
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Glaucoma, hereditary adult type 1A
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Glaucoma, hereditary juvenile type 1B
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Glaucoma, primary infantile type 3A
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Glaucoma 3 primary infantile B
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Microcornea, glaucoma, and absent frontal sinuses
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Spastic paraplegia-glaucoma-intellectual disability syndrome
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Iris hypoplasia and glaucoma
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Primary open angle glaucoma juvenile onset 1
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Tetralogy of fallot and glaucoma
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Megalocornea - spherophakia - secondary glaucoma
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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