Archive
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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Archived Hot Topics of the Day By Date
Pregnancy advances your 'biological' age - but giving birth turns it back.
Saima Sidik et al. Nature 2024 3
(Posted: Mar 25, 2024 9AM)
Health-Related quality of life and DNA Methylation-Based aging biomarkers among survivors of childhood cancer.
Noel-Marie Plonski et al. J Natl Cancer Inst 2024 3
(Posted: Mar 07, 2024 8AM)
Epigenome-wide association studies of prenatal maternal mental health and infant epigenetic profiles: a systematic review.
Emily Drzymalla et al. Transl Psychiatry 2023 12 (1) 377
(Posted: Dec 08, 2023 8AM)
Neighborhood Deprivation Measures and DNA Methylation Clocks-Understanding the Real Needs of Each Person.
Benjamin D Horne et al. JAMA Netw Open 2023 11 (11) e2344688
(Posted: Dec 02, 2023 9AM)
Navigating epigenetic epidemiology publications
W Yu et al, BMC Epig Comm, November 22, 2023,
(Posted: Nov 27, 2023 11AM)
Epigenetics of Early-Life Socioeconomic Stressors and the Impact on Childhood Body Mass Index—Potential Mechanism and Biomarker?
UP Gujral et al, JAMA Pediatrics, September 5, 2023
(Posted: Sep 05, 2023 1PM)
Salivary Epigenetic Measures of Body Mass Index and Social Determinants of Health Across Childhood and Adolescence
L Raffington et al, JAMA Pediatrics, September 5, 2023
(Posted: Sep 05, 2023 1PM)
Early-Life Adversity Associations With Later Life Epigenetic Aging Profiles in the Multi-Ethnic Study of Atherosclerosis.
Lauren L Schmitz et al. Am J Epidemiol 2023 8
(Posted: Aug 15, 2023 2PM)
Predictive evidence of the relevance of epigenetics to PTSD.
Leon Mutesa et al. Nat Rev Genet 2023 8
(Posted: Aug 09, 2023 4PM)
Epigenetic alterations in response to toxic exposures - the need to determine effect modification by nutrient status.
Krista S Crider et al. J Nutr 2023 6
(Posted: Jun 15, 2023 8AM)
Refining epigenetic prediction of chronological and biological age
E Bernabeau et al, Genome Medicine, February 28, 2023
(Posted: Mar 01, 2023 0PM)
Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns
CL Acosta et al, JAMA Network Open, February 24, 2023
(Posted: Feb 24, 2023 11AM)
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
R Waziry et al, Nature Aging, February 9, 2023
(Posted: Feb 13, 2023 10AM)
Simultaneous sequencing of genetic and epigenetic bases in DNA.
Jens Füllgrabe et al. Nature biotechnology 2023 2
(Posted: Feb 08, 2023 0PM)
Use of incorrect and correct methods to account for age in studies on epigenetic accelerated aging: implications and recommendations for best practices.
Nancy Krieger et al. American journal of epidemiology 2023 2
(Posted: Feb 05, 2023 11AM)
Epigenetic profile of Japanese supercentenarians: a cross-sectional study
S Komaki et al, The Lancet Healthy Longevity, February 2023
(Posted: Feb 03, 2023 7AM)
Molecular mechanisms of environmental exposures and human disease
H Wu et al, Nature Rev Genetics, January 30, 2023
(Posted: Jan 31, 2023 8AM)
Mapping the minutiae of the human methylome.
Minton Kirsty et al. Nature reviews. Genetics 2023 1 1
(Posted: Jan 18, 2023 1PM)
A DNA methylation atlas of normal human cell types
N Loyfer et al, Nature, January 4, 2023
(Posted: Jan 05, 2023 5AM)
Towards a unification of the 2 meanings of "epigenetics".
Huang Sui et al. PLoS biology 2022 12 (12) e3001944
(Posted: Jan 05, 2023 5AM)
DNA methylation provides molecular links underlying complex traits
Nature Genetics, January 2, 2023
(Posted: Jan 02, 2023 0PM)
Epigenetic clocks, aging, and cancer.
Johnstone Sarah E et al. Science (New York, N.Y.) 2022 12 (6626) 1276-1277
(Posted: Dec 26, 2022 11AM)
The Use of Cell-free DNA in Clinical Practice: Work in Progress
M Clyne et al, CDC Blog Post, December 14, 2022
(Posted: Dec 14, 2022 5PM)
What's my age again?
Marioni Riccardo E et al. Nature reviews. Genetics 2022 12
(Posted: Dec 09, 2022 6AM)
DNA Methylation Implicated in Human Obesity and Diabetes
ME Tucker, Medscape, November 2022
(Posted: Nov 14, 2022 6AM)
Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics.
Migliore Lucia et al. Nature reviews. Neurology 2022 9 (11) 643-660
(Posted: Nov 06, 2022 1PM)
From Polygenic Risk Scores to Methylation Risk Scores: What are the Clinical Applications?
E Drzymala et al, CDC Blog Post, October 7, 2022
(Posted: Oct 07, 2022 11AM)
Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults.
Li Xiangwei et al. Nature communications 2022 9 (1) 5269
(Posted: Sep 08, 2022 7AM)
Communicating Precision Medicine Research: Multidisciplinary Teams and Diverse Communities.
Beans Julie A et al. Public health genomics 2022 8 1-9
(Posted: Sep 01, 2022 3PM)
Methylation risk scores are associated with a collection of phenotypes within electronic health record systems
M Thompson et al, NPJ Genomic Medicine, August 26, 2022
(Posted: Aug 26, 2022 8AM)
Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women
P Jain et al, JAMA Network Open, July 27, 2022
(Posted: Jul 27, 2022 3PM)
Peripheral blood DNA methylation profiles predict future development of B-cell Non-Hodgkin Lymphoma
AE Perez et al, NPJ Precision Oncology, July 21, 2022
(Posted: Jul 22, 2022 8AM)
Fulfilling the Promise of Epigenetics Requires More Studies in Diverse Populations
E Drzymalla et al, CDC Blog Post, July 18, 2022
(Posted: Jul 18, 2022 10AM)
Diversity in EWAS: current state, challenges, and solutions
CE Breeze et al, Genome Medicine, July 6, 2022
(Posted: Jul 06, 2022 6AM)
Linking genetic variants to kidney disease via the epigenome
Nature Genetics, June 23, 2022
(Posted: Jun 25, 2022 11AM)
The missing diversity in human epigenomic studies
CE Breeze, Nature Genetics, June 9, 2022
(Posted: Jun 10, 2022 7AM)
Making sense of the ageing methylome.
Seale Kirsten et al. Nature reviews. Genetics 2022 5
(Posted: May 08, 2022 7AM)
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
M Wielscher et al, Nature Comms, May 3, 2022
(Posted: May 03, 2022 8AM)
Repeat measures of DNA methylation in an inception cohort of firefighters.
Goodrich Jaclyn M et al. Occupational and environmental medicine 2022 3
(Posted: Apr 07, 2022 2PM)
Exploring the epigenetics of resilience
R Dajani, Nature Genetics, April 4, 2022
(Posted: Apr 04, 2022 2PM)
Grandmaternal smoking during pregnancy is associated with differential DNA methylation in peripheral blood of their grandchildren
SM Watkins et al, EJHG, March 28, 2022
(Posted: Mar 29, 2022 7AM)
Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer
Q Dong et al, Genome Medicine, March 22, 2022
(Posted: Mar 23, 2022 8AM)
DNA methylation-based predictors of health: applications and statistical considerations
PD Yousefi et al, Nat Rev Genetics, March 18, 2022
(Posted: Mar 21, 2022 8AM)
Epigenetics: An Emerging Tool for Health Equity Science
E Drzymalla et al, CDC Blog Post, March 8, 2022
(Posted: Mar 08, 2022 10AM)
Racial Disparities in Ion Channelopathies and Inherited Cardiovascular Diseases Associated With Sudden Cardiac Death
M Chahine et al, May 2022
(Posted: Mar 06, 2022 7AM)
Association between maternal depression during pregnancy and newborn DNA methylation
E Drzymalla et al, Trans Psychiatry, November 9, 2021
(Posted: Nov 10, 2021 9AM)
Special focus issue on epigenomics and health disparities: foreword.
Argentieri M Austin et al. Epigenomics 2021 10
(Posted: Oct 15, 2021 10AM)
Epigenomic contributions to tumor cell heterogeneity and plasticity
R Mathur et al, Nature Genetics, October 4, 2021
(Posted: Oct 06, 2021 7AM)
Impact of paternal education on epigenetic ageing in adolescence and mid-adulthood: a multi-cohort study in the USA and Mexico.
Joyce Brian T et al. International journal of epidemiology 2021 9
(Posted: Sep 19, 2021 10AM)
Blood DNA Methylation and Incident Coronary Heart Disease
Evidence From the Strong Heart Study
AN Acien et al JAMA Cardiology, August 4, 2021
(Posted: Aug 04, 2021 11AM)
Anatomy of DNA methylation signatures: Emerging insights and applications
EC Diehl et al, AJHG, July 22, 2021
(Posted: Jul 23, 2021 7AM)
Socioeconomic changes predict genome-wide DNA methylation in childhood
J Liu et al, MEDRXIV, June 29, 2021
(Posted: Jun 30, 2021 7AM)
Epigenetic clock: a promising mirror of aging
Z Liu et al, Lancet Healthy Longevity, May 2021
(Posted: May 19, 2021 8AM)
Epigenetic-age acceleration in the emerging burden of cardiometabolic diseases among migrant and non-migrant African populations: a population-based cross-sectional RODAM substudy
FP Chilunga et al, Lancet Healthy Longevity, ay 2021
(Posted: May 19, 2021 8AM)
Clinical epigenomics for cardiovascular disease: Diagnostics and therapies.
Fischer Matthew A et al. Journal of molecular and cellular cardiology 2021 Feb
(Posted: Feb 12, 2021 11AM)
Epigenetic signatures in cancer: proper controls, current challenges and the potential for clinical translation
D Mancarella et al, Genome Medicine, February 10, 2021
(Posted: Feb 11, 2021 7AM)
Autism Spectrum Disorder from the Womb to Adulthood: Suggestions for a Paradigm Shift
C Panisi et al, JPM, January 2021
(Posted: Jan 26, 2021 8AM)
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
AK Smith et al, Nature Comm, November 2020
(Posted: Nov 25, 2020 9AM)
Association of Neighborhood Deprivation With Epigenetic Aging Using 4 Clock Metrics
KG Lawrence et al, JAMA Network Open, November 4, 2020
(Posted: Nov 05, 2020 6AM)
The immune roadmap for understanding multi-system inflammatory syndrome in children: opportunities and challenges
OM Martinez et al, Nature Medicine, November 2, 2020
(Posted: Nov 03, 2020 8AM)
Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes.
García-Calzón Sonia et al. Science translational medicine 2020 Sep (561)
(Posted: Sep 19, 2020 8PM)
A Survey of Rare Epigenetic Variation in 23,116 Human Genomes Identifies Disease-Relevant Epivariations and CGG Expansions.
Garg Paras et al. American journal of human genetics 2020 Sep
(Posted: Sep 17, 2020 10AM)
Association of Epigenetic Metrics of Biological Age With Cortical Thickness
AL Proskovec et al, JAMA Network Open, September 14, 2020
(Posted: Sep 15, 2020 7AM)
Epigenetic Therapies for Cancer
SE Bates. NEJM, August 12, 2020
(Posted: Aug 13, 2020 7AM)
What is Epigenetics?
CDC, August 2020
(Posted: Aug 05, 2020 8AM)
Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood
A Reuben et al, JAMA Network Open, June 1, 2020
(Posted: Jun 02, 2020 7AM)
The Role of Neighborhood Social Characteristics on the Epigenome—Why the Lack of Investigations?
EC Dunn, JAMA Network Open, June 1, 2020
(Posted: Jun 02, 2020 7AM)
Next-generation epigenetic inhibitors
Science, April 24, 2020
(Posted: Apr 26, 2020 10AM)
Epigenetic Therapeutics for Cardiovascular Disease- Writing, Erasing, Reading, and Maybe Forgetting
J Plutzky, JAMA, March 27, 2020
(Posted: Mar 28, 2020 8AM)
Mirror, Mirror, On The Wall: The Epigenetics Of Aging
E Matloff, Forbes, January 24, 2020
(Posted: Jan 25, 2020 8AM)
Association of Periconception Paternal Body Mass Index With Persistent Changes in DNA Methylation of Offspring in Childhood
N Noor, JAMA Network OPen, December 27, 2019
(Posted: Dec 31, 2019 9AM)
New Tests Use Epigenetics to Guess How Fast You're Aging
MC Marill, WIRED< December 2019
(Posted: Dec 25, 2019 0PM)
Cancer's epigenetic drugs: where are they in the cancer medicines?
Ghasemi Sorayya et al. The pharmacogenomics journal 2019 Dec
(Posted: Dec 12, 2019 9AM)
Genomic Tools for Environmental Epigenetics and Implications for Public Health.
Perera Bambarendage P U et al. Current opinion in toxicology 2019 Dec 1827-33
(Posted: Dec 04, 2019 10AM)
The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells.
McEwen Lisa M et al. Proceedings of the National Academy of Sciences of the United States of America 2019 Oct
(Posted: Oct 16, 2019 6AM)
A decade of epigenetic change in aging twins: genetic and environmental contributions to longitudinal DNA methylation
CA Reynolds et al, BioRXIV, September 30, 2019
(Posted: Oct 02, 2019 8AM)
Combining epigenetic drugs with other therapies for solid tumours — past lessons and future promise
D Morel et al, Nat Rev Clin Oncology, September 30, 2019
(Posted: Oct 01, 2019 8AM)
Appraising the causal relevance of DNA methylation for risk of lung cancer.
Battram Thomas et al. International journal of epidemiology 2019 Sep
(Posted: Sep 26, 2019 8AM)
First hint that body’s ‘biological age’ can be reversed-In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’, which tracks a person’s biological age.
A Abbot, Nature, September 2019
(Posted: Sep 08, 2019 7AM)
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
Q Zhang et al, Genome Medicine, August 26, 2019
(Posted: Aug 27, 2019 7AM)
Comprehensive longitudinal study of epigenetic mutations in aging
Y Wang et al, BioRXIV, AUgust 22, 2019
(Posted: Aug 23, 2019 1PM)
Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1
DE Martin-Herranz et al, Genome Biology, August 15, 2019
(Posted: Aug 16, 2019 8AM)
Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics.
Speedy Helen E et al. Nature communications 2019 Aug (1) 3615
(Posted: Aug 12, 2019 8AM)
Making the transgenerational epigenetic inheritance of trauma real
A Stelmach et al, University of Nottingham, Blog, August 2019
(Posted: Aug 03, 2019 4PM)
Advances in epigenetics link genetics to the environment and disease.
Cavalli Giacomo et al. Nature 2019 Jul (7766) 489-499
(Posted: Jul 26, 2019 2PM)
Epigenetics comes to RNA
K Garber, Science, July 5, 2019
(Posted: Jul 05, 2019 9AM)
A map of human individuality.
Koch Linda et al. Nature reviews. Genetics 2019 Jun
(Posted: Jul 01, 2019 9AM)
Epigenetic cancer evolution, one cell at a time
CN Perdigoto, Nature Rev Genetics, June 3, 2019
(Posted: Jun 03, 2019 1PM)
Points-to-consider on the return of results in epigenetic research.
Dyke Stephanie O M et al. Genome medicine 2019 May 11(1) 31
(Posted: May 29, 2019 8AM)
Mendelian Randomization and the Environmental Epigenetics of Health: a Systematic Review.
Grau-Perez Maria et al. Current environmental health reports 2019 03 (1) 38-51
(Posted: May 12, 2019 2PM)
Epigenetics in Human Obesity and Type 2 Diabetes.
Ling Charlotte et al. Cell metabolism 2019 Apr
(Posted: May 07, 2019 9AM)
Epigenetic-based therapy for colorectal cancer: Prospect and involved mechanisms.
Rezapour Saleheh et al. Journal of cellular physiology 2019 Apr
(Posted: May 07, 2019 9AM)
Aberrant DNA methylation as a diagnostic biomarker of diabetic embryopathy
KV Schulze et al. Genetics in Medicine, April 17, 2019
(Posted: Apr 17, 2019 8AM)
Epigenetics and child development: how children's experiences affect their genes
Harvard Center on the Developing Child, 2019
(Posted: Mar 11, 2019 10AM)
Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer
HP Mohammad et al, Nature Medicine, March 6, 2019
(Posted: Mar 07, 2019 9AM)
Alcohol and DNA Methylation: An Epigenome-Wide Association Study in Blood and Normal Breast Tissue
LE Wilson et al, AM J Epidemiology, February 15, 2019
(Posted: Feb 25, 2019 9AM)
Epigenetic Loci of Blood Pressure.
Syme Catriona et al. Circulation. Genomic and precision medicine 2019 Jan (1) e002341
(Posted: Jan 28, 2019 8AM)
NIH Roadmap Epigenomics Mapping Consortium
January 2019
(Posted: Jan 15, 2019 0PM)
Genomic imprinting disorders: lessons on how genome, epigenome and environment interact
D Monk et al, Nature Rev Genetics, January 15, 2019
(Posted: Jan 15, 2019 10AM)
Epigenetics may hold key to arsenics role in cancer
E Hood, The Environmental Factors, NIEHS, January 2019
(Posted: Jan 15, 2019 9AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
- Page last updated:Mar 27, 2024
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