
Archive
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
Screening Familial Risk for Hereditary Breast and Ovarian Cancer
(Posted: Oct 04, 2024 11AM)
BRCA1 and friends 30 years on
(Posted: Jul 08, 2024 8AM)
Cost-Effectiveness of Population-Based Multigene Testing for Breast and Ovarian Cancer Prevention.
Fangjian Guo et al. JAMA Netw Open 2024 2 (2) e2356078
(Posted: Feb 15, 2024 9AM)
Age-specific breast and ovarian cancer risks associated with germline BRCA1 or BRCA2 pathogenic variants – an Asian study of 572 families
WK Ho et al, Lancet Regional Health, February 2024
(Posted: Feb 06, 2024 1PM)
Secondary (additional) findings from the 100,000 Genomes Project: disease manifestation, healthcare outcomes and costs of disclosure
J Nolan et al, Genetics in Medicine, December 19, 2023
(Posted: Dec 20, 2023 9AM)
Combined population genomic screening for three high-risk conditions in Australia: a modelling study
P Lacaze et al, e Clin Medicine, November 2023
(Posted: Nov 11, 2023 4PM)
Factors associated with adherence to BRCA1/2 mutation testing after oncogenetic counseling in long-surviving patients with a previous diagnosis of breast or ovarian cancer.
Silvia Actis et al. J Community Genet 2023 9
(Posted: Sep 21, 2023 2PM)
Persistent Underutilization of BRCA Testing for Breast and Ovarian Cancer in the United States: Implications for Health Disparities
L Shi et al, CDC Blog Post, July 25, 2023
(Posted: Jul 25, 2023 11AM)
Public attitudes challenge clinical practice on genetic risk disclosure in favour of healthcare-provided direct dissemination to relatives
A Rosen et al, EJHG, July 20, 2023
(Posted: Jul 20, 2023 7AM)
The Promise of Population-based Genomic Screening for Selected Hereditary Conditions: Contributions of Cost-Effectiveness Analysis
ND Rao et al, CDC Blog Post, July 14, 2023
(Posted: Jul 14, 2023 1PM)
Germline Genetic Testing After Cancer Diagnosis.
Allison W Kurian et al. JAMA 2023 6
(Posted: Jun 06, 2023 8AM)
Summary for Patients: Population Genomic Screening for Three Common Hereditary Conditions.
et al. Ann Intern Med 2023 5 (5) I19
(Posted: Jun 02, 2023 9AM)
Population Genomic Screening for Three Common Hereditary Conditions : A Cost-Effectiveness Analysis.
Gregory F Guzauskas et al. Ann Intern Med 2023 5
(Posted: May 09, 2023 5AM)
Offering genetic testing at the point of care may increase uptake
Medical Xpress, May 3, 2023
(Posted: May 05, 2023 10AM)
Development and Evaluation of a Telephone Communication Protocol for the Delivery of Personalized Melanoma Genomic Risk to the General Population.
Georgina L Fenton et al. J Genet Couns 2017 12 (2) 370-380
(Posted: May 04, 2023 6AM)
Implementing digital systems to facilitate genetic testing for hereditary cancer syndromes: An observational study of four clinical workflows
C Wang et al, Genetics in Medicine, February 10, 2023
(Posted: Feb 11, 2023 0PM)
Relatives from Hereditary Breast and Ovarian Cancer and Lynch Syndrome Families Forgoing Genetic Testing: Findings from the Swiss CASCADE Cohort
M Sarki et al, J Per Med, October 19, 2022
(Posted: Oct 20, 2022 8AM)
Incomplete Penetrance of Population-Based Genetic Screening Results in Electronic Health Record
G Elhanan et al, Frontiers in Genetics, April 2022
(Posted: May 26, 2022 7AM)
Paired Tumor-Germline Testing as a Driver in Better Cancer Care
JW Henson et al, JAMA Network Open, May 20, 2022
(Posted: May 21, 2022 2PM)
A Mini-Symposium: Implementing Precision and Equitable Public Health in Cascade Testing for Genetic Disorders
CDC event, Feb 10, 2022
(Posted: Dec 13, 2021 2PM)
Health Equity and Genetic Disorders
CDC, August 2021
(Posted: Sep 01, 2021 7AM)
Association of Genetic Testing Results with Mortality Among Women with Breast Cancer or Ovarian Cancer.
Kurian Allison W et al. Journal of the National Cancer Institute 2021 8
(Posted: Aug 23, 2021 7AM)
BRCA2: a 25-year journey from gene identification to targeted cancer treatment.
Grinda Thomas et al. The Lancet. Oncology 2021 6 (6) 763-764
(Posted: Jun 06, 2021 7AM)
Management of individuals with germline variants in PALB2: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG)
M Tishkowitz et al, Genetics in Medicine, May 11, 2021
(Posted: May 12, 2021 8AM)
The ten genes for breast (and ovarian) cancer susceptibility.
Foulkes William D et al. Nature reviews. Clinical oncology 2021 3
(Posted: Mar 15, 2021 4PM)
Interventions Facilitating Family Communication of Genetic Testing Results and Cascade Screening in Hereditary Breast/Ovarian Cancer or Lynch Syndrome: A Systematic Review and Meta-Analysis.
Baroutsou Vasiliki et al. Cancers 2021 13(4)
(Posted: Mar 09, 2021 9AM)
Gene Sequencing for Pathogenic Variants Among Adults With Breast and Ovarian Cancer in the Caribbean
SHL George et al, JAMA Network Open, March 1, 2021
(Posted: Mar 02, 2021 8AM)
Preliminary Screening for Hereditary Breast and Ovarian Cancer Using a Chatbot Augmented Intelligence Genetic Counselor: Development and Feasibility Study.
Sato Ann et al. JMIR formative research 2021 Feb 5(2) e25184
(Posted: Feb 09, 2021 10AM)
How to Live With the Cancer You May Never Get-The waiting game is a different experience for every woman with a BRCA gene mutation
Elemental, November 6, 2020
(Posted: Nov 07, 2020 10AM)
Cost-effectiveness of Population-Wide Genomic Screening for Hereditary Breast and Ovarian Cancer in the United States
GF Gusauskas et al, JAMA Network Open, October 29, 2020
(Posted: Oct 29, 2020 11AM)
Implementing Cancer Genomics in State Health Agencies: Mapping Activities to an Implementation Science Outcome Framework.
Green Ridgely Fisk et al. Public health genomics 2020 Sep 1-12
(Posted: Sep 18, 2020 9AM)
Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions
AC Fahed et al, Nature Communications, August 20, 2020
(Posted: Aug 21, 2020 9AM)
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants
DR Barnes et al, Genetics in Medicine, July 15, 2020
(Posted: Jul 17, 2020 11AM)
Updates in BRCA testing for People of Ashkenazi Jewish Ancestry
L Steinmark, Jackson Labs, May 3, 2020
(Posted: May 07, 2020 8AM)
Association of Rare Pathogenic DNA Variants for Familial Hypercholesterolemia, Hereditary Breast and Ovarian Cancer Syndrome, and Lynch Syndrome With Disease Risk in Adults According to Family History
AP Patel, JAMA Network Open, April 29, 2020
(Posted: Apr 30, 2020 8AM)
Mayo genomic database to use sequencing for 100K participants
G Slabodkin, Health Data Management, January 10, 2020
(Posted: Jan 13, 2020 9AM)
Impact of proactive high-throughput functional assay data on BRCA1 variant interpretation in 3684 patients with breast or ovarian cancer
HK Kim, J Hum Genetics, January 2020
(Posted: Jan 13, 2020 9AM)
New PARP Inhibitor Approval for Pancreatic Cancer
L Schlager, FORCE, January 6, 2020
(Posted: Jan 07, 2020 8AM)
Heartbreaking News, Then Tumor Find Leads to Genetic Testing
V Hackethal, Medscape, December 27, 2019
(Posted: Dec 29, 2019 8AM)
A Genetic Test Led Seven Women in One Family to Have Major Surgery. Then the Odds Changed.
WSJ, December 20,2019
(Posted: Dec 21, 2019 4PM)
Reducing Disparities in Receipt of Genetic Counseling for Underserved Women at Risk of Hereditary Breast and Ovarian Cancer.
Sutton Arnethea L et al. Journal of women's health (2002) 2019 Nov
(Posted: Dec 11, 2019 9AM)
Low rates of cascade genetic testing among families with hereditary gynecologic cancer: An opportunity to improve cancer prevention.
Griffin Natalie E et al. Gynecologic oncology 2019 Nov
(Posted: Dec 04, 2019 10AM)
Retesting of women who are negative for a BRCA1 and BRCA2 mutation using a 20-gene panel.
Lerner-Ellis Jordan et al. Journal of medical genetics 2019 Nov
(Posted: Dec 03, 2019 8AM)
CMS Aims to Broaden Coverage for NGS Testing in Breast, Ovarian Cancer -Expansion would include patients with risk factors for inherited susceptibility mutations
I Ingram, MedPage Today, October 31, 2019
(Posted: Nov 05, 2019 9AM)
General “Take Action” Infographic
CDC Cancer, 2019
(Posted: Oct 08, 2019 8AM)
Population prevalence of individuals meeting criteria for hereditary breast and ovarian cancer testing.
Greenberg Samantha et al. Cancer medicine 2019 Sep
(Posted: Sep 25, 2019 9AM)
Randomised trial of population-based BRCA testing in Ashkenazi Jews: long-term outcomes.
Manchanda R et al. BJOG : an international journal of obstetrics and gynaecology 2019 Sep
(Posted: Sep 18, 2019 9AM)
Learn Your Family History of Breast and Ovarian Cancer
CDC, 2019
(Posted: Sep 16, 2019 8AM)
USPSTF Recommendation Expands Cancer Screening Pool, Concerns Still Remain
KL Kahl, Cure, August 26, 2019
(Posted: Aug 27, 2019 7AM)
Genetic Testing Can Reduce Suffering and Save Lives
L Corduck, AJMC, August 14, 2019
(Posted: Aug 15, 2019 8AM)
PARP Inhibitors Hit the Pancreatic Cancer Scene
D Ternyila, Oncology Nursing News, August 9, 2019
(Posted: Aug 13, 2019 8AM)
Infographic: What Every Young Woman Needs to Know About Hereditary Breast and Ovarian Cancer
CDC, 2019
(Posted: Jul 17, 2019 9AM)
The 2019 HBOC and Lynch Syndrome Family Day
Michigan Public Health Institute, Register for event, September 21, 2019
(Posted: Jul 12, 2019 8AM)
Nevada Health Study Using Genetics To Fight Disease Statewide
N Glick, KUNR, June 28, 2019
(Posted: Jul 01, 2019 1PM)
Developing a culturally targeted video to enhance the use of genetic counseling in Latina women at increased risk for hereditary breast and ovarian cancer.
Hurtado-de-Mendoza Alejandra et al. Journal of community genetics 2019 May
(Posted: May 22, 2019 8AM)
Consensus guidelines for genetic testing for hereditary breast and ovarian cancer
American Society for Breast Surgeons, February 14, 2019
(Posted: Feb 16, 2019 0PM)
Reinterpretation of BRCA1 and BRCA2 variants of uncertain significance in patients with hereditary breast/ovarian cancer using the ACMG/AMP 2015 guidelines.
So Min-Kyung et al. Breast cancer (Tokyo, Japan) 2019 Feb
(Posted: Feb 12, 2019 10AM)
High-risk breast cancer surveillance with MRI: 10-year experience from the German consortium for hereditary breast and ovarian cancer.
Bick Ulrich et al. Breast cancer research and treatment 2019 Feb
(Posted: Feb 12, 2019 10AM)
Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop.
Nikolaidis Christos et al. Public health genomics 2019 Jan 1-12
(Posted: Jan 30, 2019 9AM)
Communication About Hereditary Cancers on Social Media: A Content Analysis of Tweets About Hereditary Breast and Ovarian Cancer and Lynch Syndrome.
Allen Caitlin G et al. Journal of cancer education : the official journal of the American Association for Cancer Education 2018 Dec
(Posted: Dec 09, 2018 4PM)
Prevalence of nonfounder BRCA1/2 mutations in Ashkenazi Jewish patients presenting for genetic testing at a hereditary breast and ovarian cancer center.
Frey Melissa K et al. Cancer 2018 Nov
(Posted: Dec 04, 2018 10AM)
Personalised medicine and population health: breast and ovarian cancer.
Narod Steven A et al. Human genetics 2018 Oct
(Posted: Oct 20, 2018 4PM)
Population-based genetic testing of asymptomatic women for breast and ovarian cancer susceptibility.
Rowley Simone M et al. Genetics in medicine : official journal of the American College of Medical Genetics 2018 Sep
(Posted: Sep 27, 2018 7AM)
BRCA1 and BRCA2 Testing in Medically Underserved Medicare Beneficiaries With Breast or Ovarian Cancer
AL Gross et al, JAMA, August 14, 2018
(Posted: Aug 15, 2018 8AM)
Improving comprehension of genetic counseling for hereditary breast and ovarian cancer clients with a visual tool.
Tea Muy-Kheng M et al. PloS one 2018 13(7) e0200559
(Posted: Jul 18, 2018 9AM)
Underdiagnosis of Hereditary Breast and Ovarian Cancer in Medicare Patients: Genetic Testing Criteria Miss the Mark.
Yang Shan et al. Annals of surgical oncology 2018 Jul
(Posted: Jul 13, 2018 2PM)
Genetic screening can inform women of their breast and ovarian cancer risks
L Abaid, LA Times, July 5, 2018
(Posted: Jul 06, 2018 8AM)
The uptake of presymptomatic genetic testing in hereditary breast-ovarian cancer and Lynch syndrome: a systematic review of the literature and implications for clinical practice.
Menko Fred H et al. Familial cancer 2018 May
(Posted: Jun 11, 2018 11AM)
Concurrent risk-reduction surgery in patients with increased lifetime risk for breast and ovarian cancer: an analysis of the National Surgical Quality Improvement Program (NSQIP) database.
Elmi Maryam et al. Breast cancer research and treatment 2018 May
(Posted: May 25, 2018 8AM)
National Distribution of Cancer Genetic Testing in the United States-
Evidence for a Gender Disparity in Hereditary Breast and Ovarian Cancer
K Childers et al, JAMA Onc, Apr 26, 2018
(Posted: Apr 27, 2018 1PM)
Risks of breast or ovarian cancer in BRCA1 or BRCA2 predictive test negatives: findings from the EMBRACE study
F Girardi et al, Genetics in Medicine, Mar 22, 2018
(Posted: Mar 22, 2018 0PM)
Inherited BRCA1 epimutation as a novel cause of breast and ovarian cancer
DGR Evans, BioRXIV, Jan 2018
(Posted: Jan 22, 2018 1PM)
Investigating barriers to genetic counseling and germline mutation testing in women with suspected hereditary breast and ovarian cancer syndrome and Lynch syndrome.
Shaw Josephine et al. Patient education and counseling 2017 Dec
(Posted: Jan 03, 2018 10AM)
Professionals' knowledge, attitude and referral behaviour of preimplantation genetic diagnosis for hereditary breast and ovarian cancer.
Gietel-Habets J J G et al. Reproductive biomedicine online 2017 Dec
(Posted: Dec 17, 2017 0PM)
Randomized Noninferiority Trial of Telephone vs In-Person Genetic Counseling for Hereditary Breast and Ovarian Cancer: A 12-Month Follow-Up
MK Interrante et al, JNCI Cancer Spectrum, Sept 2017
(Posted: Dec 01, 2017 9AM)
Breast and Ovarian Cancer Penetrance Estimates Derived From Germline Multiple-Gene Sequencing Results in Women
AW Kurian et al, J Precision Oncology, Oct 2017
(Posted: Oct 15, 2017 11AM)
Genetic/Familial High Risk Assessment: Breast and Ovarian Cancer
NCCN Guidelines, October 2017
(Posted: Oct 06, 2017 0PM)
Cancer Predisposition Cascade Screening for Hereditary Breast/Ovarian Cancer and Lynch Syndromes in Switzerland: Study Protocol.
Katapodi Maria C et al. JMIR research protocols 2017 Sep 6(9) e184
(Posted: Sep 27, 2017 10AM)
Practice Bulletin No. 182 Summary: Hereditary Breast and Ovarian Cancer Syndrome.
et al. Obstetrics and gynecology 2017 Sep 130(3) 657-659
(Posted: Aug 30, 2017 9AM)
Practice Bulletin No 182: Hereditary Breast and Ovarian Cancer Syndrome.
et al. Obstetrics and gynecology 2017 130(3) e110-e126
(Posted: Aug 30, 2017 9AM)
National Estimates of Genetic Testing in Women With a History of Breast or Ovarian Cancer.
Childers Christopher P et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Aug JCO2017736314
(Posted: Aug 24, 2017 1PM)
Take Action to Lower Your Breast and Ovarian Cancer Risk
(Posted: Jul 13, 2017 3PM)
Breast and Ovarian Cancer Penetrance Estimates Derived From Germline Multiple-Gene Sequencing Results in Women
AW Kurian, JCO Precision Oncology, June 27, 2017
(Posted: Jun 28, 2017 0PM)
Age-specific overall risk of breast, ovarian cancer among women with BRCA1/2 genetic mutations
Science Mag, June 20, 2017
(Posted: Jun 25, 2017 3PM)
"When information is not enough": A model for understanding BRCA-positive previvors' information needs regarding hereditary breast and ovarian cancer risk.
Dean Marleah et al. Patient education and counseling 2017 Mar
(Posted: Apr 12, 2017 8AM)
Cost-effectiveness of different strategies to prevent breast and ovarian cancer in German women with a BRCA 1 or 2 mutation.
Müller Dirk et al. The European journal of health economics : HEPAC : health economics in prevention and care 2017 Apr
(Posted: Apr 12, 2017 8AM)
Risk of breast cancer after a diagnosis of ovarian cancer in BRCA mutation carriers: Is preventive mastectomy warranted?
McGee Jacob et al. Gynecologic oncology 2017 Mar
(Posted: Mar 22, 2017 10AM)
NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2017.
Daly Mary B et al. Journal of the National Comprehensive Cancer Network : JNCCN 2017 Jan 15(1) 9-20
(Posted: Jan 11, 2017 9AM)
Tracking the dissemination of a culturally targeted brochure to promote awareness of hereditary breast and ovarian cancer among Black women.
Scherr Courtney Lynam et al. Patient education and counseling 2016 Oct
(Posted: Nov 30, 2016 11AM)
Breast and Ovarian Cancer
(Posted: Oct 10, 2016 1PM)
Psychosocial outcomes and counselee satisfaction following genetic counseling for hereditary breast and ovarian cancer: A patient-reported outcome study.
Oberguggenberger Anne et al. Journal of psychosomatic research 2016 Oct 8939-45
(Posted: Sep 27, 2016 11AM)
Hereditary breast and ovarian cancer: successful systematic implementation of a group approach to genetic counselling.
Benusiglio Patrick R et al. Familial cancer 2016 Sep
(Posted: Sep 21, 2016 10AM)
Public Health Approaches and Barriers to Educating Providers about Hereditary Breast and Ovarian Cancer Syndrome.
Trepanier Angela M et al. Healthcare (Basel, Switzerland) 2016 4(1)
(Posted: Jul 19, 2016 10AM)
Screening for germline mutations in breast/ovarian cancer susceptibility genes in high-risk families in Israel.
Yablonski-Peretz Tamar et al. Breast cancer research and treatment 2016 Jan (1) 133-8
(Posted: Jan 12, 2016 10AM)
SEOM clinical guidelines in Hereditary Breast and ovarian cancer.
Llort G et al. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2015 Dec 17(12) 956-61
(Posted: Dec 29, 2015 10AM)
The Activities and Impact of State Programs to Address Hereditary Breast and Ovarian Cancer, 20112014
K Trivers et al, Healthcare, December 2015
(Posted: Nov 01, 2015 2PM)
Initial Results of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer and Lynch Syndrome.
Howarth Dt R et al. The American surgeon 2015 Oct (10) 941-4
(Posted: Oct 31, 2015 9AM)
Next-Generation Gene Sequencing: Looking Beyond Hereditary Breast and Ovarian Cancer.
Estrada Sylvia S et al. Oncology nursing forum 2015 Nov (6) 691-4
(Posted: Oct 31, 2015 9AM)
Does Breast or Ovarian Cancer Run in Your Family?
(Posted: Oct 20, 2015 4PM)
Utilization and Outcomes of BRCA Genetic Testing and Counseling in a National Commercially Insured PopulationThe ABOUT Study
J Armstrong et al. JAMA Oncology, October 1, 2015
(Posted: Oct 05, 2015 9AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
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