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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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120 hot topic(s) found with the query "Asthma"

Genetics of chronic respiratory disease.
Ian Sayers et al. Nat Rev Genet 2024 3 (Posted: Mar 07, 2024 8AM)

From the abstract: "Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma and interstitial lung diseases are frequently occurring disorders with a polygenic basis that account for a large global burden of morbidity and mortality. Recent large-scale genetic epidemiology studies have identified associations between genetic variation and individual respiratory diseases and linked specific genetic variants to quantitative traits related to lung function. "

The infant gut virome is associated with preschool asthma risk independently of bacteria
CL Rodriguez et al, Nature Medicine, December 15, 2023 (Posted: Dec 15, 2023 8AM)

From the abstract: "Here, we analyze the gut virome of 647 children aged 1?year from the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) mother–child cohort, all deeply phenotyped from birth and with longitudinally assessed asthma diagnoses. Specific temperate gut phage taxa were found to be associated with later development of asthma. In particular, the joint abundances of 19 caudoviral families were found to significantly contribute to this association. Combining the asthma-associated virome and bacteriome signatures had additive effects on asthma risk."

Cord blood DNA methylation signatures associated with preeclampsia are enriched for cardiovascular pathways: insights from the VDAART trial.
Hanna M Knihtilä et al. EBioMedicine 2023 11 104890 (Posted: Nov 29, 2023 9AM)

From the abstract: "Preeclampsia has been associated with maternal epigenetic changes, in particular DNA methylation changes in the placenta. It has been suggested that preeclampsia could also cause DNA methylation changes in the neonate. We examined DNA methylation in relation to gene expression in the cord blood of offspring born to mothers with preeclampsia. This study included 128 mother-child pairs who participated in the Vitamin D Antenatal Asthma Reduction Trial (VDAART), where assessment of preeclampsia served as secondary outcome. We found that preeclampsia is related to differential cord blood DNA methylation signatures of cardiovascular pathways, including the apelin signaling pathway. "

Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial
EM Hale et al, Lancet Resp Medicine, March 21, 2023 (Posted: Mar 22, 2023 7AM)

The clinical value of using digital tools to assess adherence and lung function in uncontrolled asthma is not known. We aimed to compare treatment decisions guided by digitally acquired data on adherence, inhaler technique, and peak flow with existing methods. This RCT found that evidence-based care informed by digital data led to a modest improvement in medication adherence and a significantly lower treatment burden.

Polygenic Risk Scores for Asthma and Allergic Disease Associate with COVID-19 Severity in 9/11 Responders
M Wasczuk et al, MEDRXIV, February 16, 2023 (Posted: Feb 17, 2023 6AM)

Relatively little is known about the associations between PRS and COVID-19 severity or post-acute COVID-19 in community-dwelling individuals. Methods. Participants in this study were 983 World Trade Center responders infected for the first time with SARS-CoV-2. The results indicate that recently developed polygenic biomarkers for asthma, allergic disease, and COVID-19 hospitalization capture some of the individual differences in severity and clinical course of COVID-19 illness in a community population.

Genomics and phenomics of body mass index reveals a complex disease network.
Huang Jie et al. Nature communications 2022 12 (1) 7973 (Posted: Jan 02, 2023 0PM)

Using a BMI genetic risk score including 2446 variants, 316 diagnoses are associated in the Million Veteran Program, with 96.5% showing increased risk. A co-morbidity network analysis reveals seven disease communities containing multiple interconnected diseases associated with BMI as well as extensive connections across communities. Mendelian randomization analysis confirms phenotypes across many organ systems, including conditions of the circulatory (heart failure, ischemic heart disease, atrial fibrillation), genitourinary (chronic renal failure), respiratory (respiratory failure, asthma), musculoskeletal and dermatologic systems.

An accurate deep learning model for wheezing in children using real world data
BJ Kim et al, Sci Reports, December 28, 2022 (Posted: Dec 28, 2022 11AM)

We aimed to develop an improved deep-learning model learning to detect wheezing in children, based on data from real clinical practice. In this prospective study, pediatric pulmonologists recorded and verified respiratory sounds in 76 pediatric patients who visited a university hospital. In addition, structured data, such as sex, age, and auscultation location, were collected. Using our dataset, we implemented an optimal model by transforming it based on the convolutional neural network model.

The Social Vulnerability Metric (SVM) As A New Tool for Public Health.
Saulsberry Loren et al. Health services research 2022 11 (Posted: Nov 21, 2022 7AM)

The Social Vulnerability Metric (SVM) was constructed from U.S. zip-code level measures (2018) from survey data using multidimensional Item Response Theory and validated using outcomes including all-cause mortality (2016), COVID-19 vaccination (2021), and emergency department visits for asthma (2018). The correlation between SVM scores and national age-adjusted county all-cause mortality was r=0.68. This correlation demonstrated the SVM’s robust validity and outperformed the SVI with an almost four-fold increase in explained variance (46% versus 12%).

Asthma: From Phenotypes to Personalized Medicine
P Bakakos, J Per Med, November 6, 2022 (Posted: Nov 06, 2022 8AM)

Asthma is a heterogeneous disease of the airways with a high prevalence worldwide characterized by chronic inflammation. The aim of asthma management is the control of the disease, and the cornerstone of asthma treatment is inhaled corticosteroids. Asthma is no longer recognized as a unique manifestation, and the “one size fits all” approach may apply only in the treatment of mild asthma.

Measurement of Exhaled Volatile Organic Compounds as a Biomarker for Personalised Medicine: Assessment of Short-Term Repeatability in Severe Asthma
A Azim et al, J Per Medicine, September 29, 2022 (Posted: Oct 02, 2022 9AM)

The intra-subject and between-subject variability of each VOC was calculated across the 70 samples and identified 30.35% of VOCs to be erratic: variable between subjects but also variable in the same subject. Exclusion of these erratic VOCs from machine learning approaches revealed no apparent loss of structure to the underlying data or loss of relationship with salient clinical characteristics. Moreover, cluster evaluation by the silhouette coefficient indicates more distinct clustering.

Polygenic Risk Scores for Asthma and Allergic Disease Predict COVID-19 Severity in 9/11 Responders
M Wazczuk et al, MEDRXIV, August 31, 2022 (Posted: Aug 31, 2022 7AM)

Effectiveness and durability of the mRNA vaccine-induced SARS-CoV-2-specific humoral and cellular immunity in severe asthma patients on biological therapy
M Podrazil et al, MEDRXIV, February 17, 2022 (Posted: Feb 19, 2022 7AM)

Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome
C Cervia et al, Nature Comms, January 25, 2022 (Posted: Jan 26, 2022 8AM)

In a prospective multicentric cohort study of 215 individuals, we study COVID-19 patients during primary infection and up to one year later, compared to healthy subjects. We discover an immunoglobulin (Ig) signature, based on total IgM and IgG3 levels, which – combined with age, history of asthma, and five symptoms during primary infection – is able to predict the risk of PACS independently of timepoint of blood sampling.

Identifying Louisiana Communities at the Crossroads of Environmental and Social Vulnerability, COVID-19, and Asthma
A Bakshi et al, MEDRXIV, July 19, 2021 (Posted: Jul 20, 2021 6AM)

Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma
J Stockholm et al, Sci Trans Med, November 11, 2020 (Posted: Nov 12, 2020 8AM)

Children born by cesarean section have an increased risk of developing asthma compared to children born by vaginal delivery and also have an altered gut microbiota composition. The study found an increased risk of asthma in children born by cesarean section if their gut microbiota profile at 1 year of age remained similar to that at birth.

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma
M Depner et al, Nature Medicine, November 2, 2020 (Posted: Nov 03, 2020 8AM)

We modeled maturation using 16S rRNA sequence data of the human gut microbiome in infants from 2 to 12 months of age. The estimated microbiome age (EMA) in 12-month-old infants was associated with previous farm exposure (ß?=?0.27 (0.12–0.43), P?=?0.001, n?=?618) and reduced risk of asthma at school age (odds ratio (OR)?=?0.72 (0.56–0.93), P?=?0.011).

Large Study Links Asthma, Allergic Rhinitis to Severe COVID-19
Reuters, August 27, 2020 (Posted: Aug 30, 2020 11AM)

People with Moderate to Severe Asthma
CDC, August 2020 Brand (Posted: Aug 28, 2020 8AM)

People with moderate to severe asthma may be at higher risk of getting very sick from COVID-19. COVID-19 can affect your nose, throat, lungs (respiratory tract); cause an asthma attack; and possibly lead to pneumonia and acute respiratory disease.

OpenSAFELY: factors associated with COVID-19 death in 17 million patients
EJ Williamson et al, Nature, July 8, 2020 (Posted: Jul 08, 2020 9AM)

Primary care records of 17,278,392 adults were pseudonymously linked to 10,926 COVID-19-related deaths. COVID-19-related death was associated with: being male (hazard ratio (HR) 1.59, 95% confidence interval (CI) 1.53–1.65); older age and deprivation (both with a strong gradient); diabetes; severe asthma; and various other medical conditions.

Does asthma increase Covid-19 risk? Emerging research suggests a complicated connection
J Isselbacher, Stat News, July 2, 2020 (Posted: Jul 04, 2020 7AM)

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults
S Bunyavanich et al, May 20, 2020 (Posted: May 20, 2020 11AM)

This study shows age-dependent expression of ACE2 in nasal epithelium, the first point of contact for SARS-CoV-2 and the human body. Models showed that the positive association between ACE2 gene expression and age was independent of sex and asthma. Lower ACE2 expression in children relative to adults may help explain why COVID-19 is less prevalent in children.

Artificial Intelligence techniques in Asthma:A systematic review and critical appraisal of the existing literature.
Exarchos Konstantinos P et al. The European respiratory journal 2020 May (Posted: May 12, 2020 3PM)

Asthma genetics revisited: understanding disease mechanisms by studying ethnically diverse groups
E Melen, Lancet Respiratory Diseases, May 2020 (Posted: May 06, 2020 7AM)

Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020
CDC MMWR, April 6, 2020 Brand (Posted: Apr 06, 2020 2PM)

Among 345 pediatric cases, 80 (23%) had at least one underlying condition. The most common underlying conditions were chronic lung disease (including asthma) (40), cardiovascular disease (25), and immunosuppression (10). 77% of hospitalized patients, including all six patients admitted to an ICU, had one or more underlying medical condition.

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation.
King Charlotte et al. The pharmacogenomics journal 2020 Jan (Posted: Jan 18, 2020 9AM)

A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken. Five studies met the inclusion criteria. Two of the polymorphisms were replicated within the paper, but none had external replication. Future pharmacogenomic studies in asthma should collect relevant ADR data.

African American children may need different asthma treatments
NIH, October 2019 Brand (Posted: Oct 16, 2019 5AM)

About half of African American children with poorly controlled asthma benefited more from higher-dose steroids than adding a bronchodilator to treatment. These findings highlight the importance of enrolling populations of diverse ages and races in clinical trials.

Diagnostic Interpretation of Genetic Studies in Patients with Primary Immunodeficiency Diseases: A Working Group Report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma, and Immunology.
Chinn Ivan K et al. The Journal of allergy and clinical immunology 2019 Sep (Posted: Oct 02, 2019 8AM)

Genetic testing has become an integral component of the diagnostic evaluation of patients with suspected primary immunodeficiency diseases. Results of genetic testing can have profound impact on clinical management decisions. Clinical providers must therefore demonstrate proficiency in interpreting genetic data.

New Opportunities With School-Based Telehealth: Convenient Connections to Care.
Frey Sean M et al. JAMA pediatrics 2019 Sep (Posted: Sep 10, 2019 9AM)

Future studies should test whether telemedicine can similarly improve the delivery of guideline-based preventive care for children with asthma and other chronic conditions, including attention deficit/hyperactivity disorder and diabetes. All children may not benefit equally from school-based telemedicine.

Association of a School-Based, Asthma-Focused Telehealth Program With Emergency Department Visits Among Children Enrolled in South Carolina Medicaid.
Bian John et al. JAMA pediatrics 2019 Sep (Posted: Sep 10, 2019 9AM)

Multiple genes affect risk of asthma, hay fever and eczema
Upsala University, Science Daily, August 5, 2019 (Posted: Aug 07, 2019 7AM)

In a new study from SciLifeLab at Uppsala University, researchers have found a total of 141 regions (genes) in our genetic material that largely explain the genetic risk underlying asthma, hay fever and eczema. As many as 41 of the genes identified have not previously been linked to an elevated risk for these diseases.

A host gene expression approach for identifying triggers of asthma exacerbations.
Lydon Emily C et al. PloS one 2019 (4) e0214871 (Posted: Jul 28, 2019 4PM)

Precision Medicine for Lung Diseases: A National Heart, Lung, and Blood Institute Perspective.
Croxton Thomas et al. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2019 Jul (Posted: Jul 10, 2019 8AM)

Leveraging -omics for asthma endotyping
SR Tyler et al, JACI, July 2019 (Posted: Jul 02, 2019 0PM)

Asthma is a highly heterogeneous disease, The eliciting factors, natural history, underlying molecular biology, and clinical management of asthma vary highly among affected subjects. Because of this variation, many efforts have gone into subtyping asthma. Endotypes are subtypes of disease based on distinct pathophysiologic mechanisms. We discuss the application of -omics approaches, including transcriptomics, epigenomics, microbiomics, metabolomics, and proteomics, to asthma endotyping. -Omics approaches have provided supporting evidence for many existing endotyping paradigms and also suggested novel ways to conceptualize asthma endotypes.

Farm-like indoor microbiota in non-farm homes protects children from asthma development
Nature Medicine, June 17, 2019 (Posted: Jun 18, 2019 8AM)

Asthma severity, nature or nurture: genetic determinants.
Raby Benjamin A et al. Current opinion in pediatrics 2019 Jun (3) 340-348 (Posted: May 20, 2019 8AM)

Statement on World Asthma Day 2019
NIH, May 7, 2019 Brand (Posted: May 07, 2019 10AM)

Epigenomics and Transcriptomics in the Prediction and Diagnosis of Childhood Asthma: Are We There Yet?
Forno Erick et al. Frontiers in pediatrics 2019 115 (Posted: May 06, 2019 2PM)

What did we learn from multiple omics studies in asthma?
Ivanova Olga et al. Allergy 2019 Apr (Posted: May 06, 2019 2PM)

Epigenome Wide Association Studies in Asthma: A Systematic Review.
Edris Ahmed et al. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2019 Apr (Posted: May 06, 2019 2PM)

Asthma severity, nature or nurture: genetic determinants.
Raby Benjamin A et al. Current opinion in pediatrics 2019 Mar (Posted: Apr 22, 2019 9AM)

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct
MAR Ferreira et al, AJHG, March 27, 2019 (Posted: Mar 31, 2019 5PM)

Genetics and pollution drive severity of asthma symptoms
NIH Release, August 31, 2018 Brand (Posted: Aug 31, 2018 11AM)

Age at puberty and risk of asthma: A Mendelian randomisation study.
Minelli Cosetta et al. PLoS medicine 2018 Aug (8) e1002634 (Posted: Aug 08, 2018 1PM)

Precision Medicine in Targeted Therapies for Severe Asthma: Is There Any Place for "Omics" Technology?
Galeone Carla et al. BioMed research international 2018 20184617565 (Posted: Jul 18, 2018 9AM)

The Pharmacogenomics of Asthma beyond its Endotypes.
Meng Shuhui et al. Current drug metabolism 2018 Jun (Posted: Jul 03, 2018 11AM)

A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases
Z. Zhu et al, Nature Genetics, May 21, 2018 (Posted: May 21, 2018 2PM)

NIH statement on World Asthma Day 2018
NIH video: patients and scientists work together to advance asthma research. Brand (Posted: May 01, 2018 0PM)

Update on asthma genetics: Results from meta-analyses of candidate gene association studies.
Tizaoui K et al. Current molecular medicine 2018 Mar (Posted: Apr 09, 2018 10AM)

Prevalence of Asthma, Asthma Attacks, and Emergency Department Visits for Asthma Among Working Adults - National Health Interview Survey, 2011-2016.
Mazurek Jacek M et al. MMWR. Morbidity and mortality weekly report 2018 Apr (13) 377-386 (Posted: Apr 09, 2018 10AM)

The use of pharmacogenomics, epigenomics, and transcriptomics to improve childhood asthma management: Where do we stand?
Farzan Niloufar et al. Pediatric pulmonology 2018 Mar (Posted: Mar 13, 2018 0PM)

Lessons from ten years of genome-wide association studies of asthma.
Vicente Cristina T et al. Clinical & translational immunology 2017 Dec (12) e165 (Posted: Feb 07, 2018 10AM)

How to Control Asthma with Personalized Management: Where Do We Stand Now?
Wang Meng et al. Current drug metabolism 2018 Jan (Posted: Feb 07, 2018 10AM)

Asthma in children: Working together to get it under control
CDC Vital Signs, Feb 2018 Brand (Posted: Feb 07, 2018 10AM)

Pharmacogenetic and pharmacogenomic considerations of asthma treatment.
Matera Maria Gabriella et al. Expert opinion on drug metabolism & toxicology 2017 Nov 13(11) 1159-1167 (Posted: Nov 15, 2017 9AM)

Treatment response heterogeneity in asthma: the role of genetic variation.
Vijverberg Susanne J H et al. Expert review of respiratory medicine 2017 Nov (Posted: Nov 15, 2017 9AM)

The environment, epigenome, and asthma.
Yang Ivana V et al. The Journal of allergy and clinical immunology 2017 Jul (1) 14-23 (Posted: Oct 30, 2017 2PM)

Pharmacogenetics and the treatment of asthma.
Isidoro-García María et al. Pharmacogenomics 2017 Aug (13) 1271-1280 (Posted: Oct 30, 2017 2PM)

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
MA Ferrerira et al, Nat Genet, Oct 30, 2017 (Posted: Oct 30, 2017 2PM)

Precision medicine in asthma: linking phenotypes to targeted treatments.
Chung Kian F et al. Current opinion in pulmonary medicine 2017 Oct (Posted: Oct 18, 2017 11AM)

Immune monitoring for precision medicine in allergy and asthma.
Boyd Scott Dexter et al. Current opinion in immunology 2017 Sep 82-91 (Posted: Oct 09, 2017 5PM)

A genome-by-environment interaction classifier for precision medicine: personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations
V Gardeaux et al, JAMIA, Jul 2017 (Posted: Oct 09, 2017 5PM)

Most Recent Asthma Data
Brand (Posted: Jul 12, 2017 6PM)

Is the atopic march related to confounding by genetics and early life environment? A systematic review of sibship and twin data.
Khan Sabria J et al. Allergy 2017 Jun (Posted: Jul 12, 2017 6PM)

Pathogenesis of asthma: implications for precision medicine.
Russell Richard J et al. Clinical science (London, England : 1979) 2017 Jul (14) 1723-1735 (Posted: Jul 12, 2017 6PM)

Gene-Environment Interactions-What Can These Tell Us about the Relationship between Asthma and Allergy?
Turner Steve et al. Frontiers in pediatrics 2017 118 (Posted: Jul 08, 2017 7PM)

Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature.
Rodríguez-Martínez Carlos E et al. Journal of asthma and allergy 2017 83-98 (Posted: May 31, 2017 11AM)

State-of-the-art testing for alpha-1 antitrypsin deficiency.
Kueppers Friedrich et al. Allergy and asthma proceedings 2017 Mar (2) 108-114 (Posted: May 01, 2017 10AM)

The microbiome in allergic disease: Current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology.
Huang Yvonne J et al. The Journal of allergy and clinical immunology 2017 Apr (4) 1099-1110 (Posted: May 01, 2017 10AM)

Genetic Signatures of Asthma Exacerbation.
Park Heung Woo et al. Allergy, asthma & immunology research 2017 May (3) 191-199 (Posted: May 01, 2017 10AM)

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children
MM Stein et al, NEJM, August 3, 2016 (Posted: Aug 04, 2016 8AM)

Innate Immunity in Asthma
TA Chatilla, NEJM, AUgust 3 2016 (Posted: Aug 04, 2016 8AM)

Genetics and Genomics of Longitudinal Lung Function Patterns in Asthmatics
MJ McGeachie et al, Am J Respir Crit Care Med. July 2016 (Posted: Jul 04, 2016 7AM)

You Can Control Your Asthma
Brand (Posted: May 20, 2016 5PM)

Toward precision medicine and health: Opportunities and challenges in allergic diseases.
Galli Stephen Joseph et al. The Journal of allergy and clinical immunology 2016 May (5) 1289-300 (Posted: May 20, 2016 2PM)

Asthma Genetics in the Post-GWAS Era.
Ober Carole et al. Annals of the American Thoracic Society 2016 Mar S85-90 (Posted: May 03, 2016 6PM)

CDC’s National Asthma Control Program
Program helps Americans with asthma achieve better health and improved quality of life Brand (Posted: May 03, 2016 6PM)

Leveraging gene-environment interactions and endotypes for asthma gene discovery.
Bønnelykke Klaus et al. The Journal of allergy and clinical immunology 2016 Mar (3) 667-79 (Posted: Mar 19, 2016 0PM)

Novel Genetic Risk factors for Asthma in African American Children: Precision Medicine and The SAGE II Study.
MJ White et al, BioxRIV, March 2016 (Posted: Mar 19, 2016 11AM)

Asthma Pharmacogenomics: 2015 Update.
Davis Joshua S et al. Current allergy and asthma reports 2015 Jul (7) 42 (Posted: Dec 09, 2015 7PM)

Asthma risk factors.
Toskala Elina et al. International forum of allergy & rhinology 2015 Sep S11-6 (Posted: Dec 09, 2015 7PM)

Histone Modifications and Asthma- the Interface of the Epigenetic and Genetic Landscapes.
Kidd Courtney D A et al. American journal of respiratory cell and molecular biology 2015 Sep (Posted: Dec 09, 2015 7PM)

Mapping asthma-associated variants in admixed populations.
Mersha Tesfaye B et al. Frontiers in genetics 2015 292 (Posted: Dec 09, 2015 7PM)

Phenotypes, Risk Factors, and Mechanisms of Adult-Onset Asthma.
Ilmarinen Pinja et al. Mediators of inflammation 2015 514868 (Posted: Dec 09, 2015 7PM)

Don’t blame grandma yet, but your asthma may be her fault
By N Akpan, PBS Newshour, December 9, 2015 (Posted: Dec 09, 2015 7PM)

The impact of parental history on children's risk of asthma: a study based on the National Health and Nutrition Examination Survey-III.
Xu Rengyi et al. J Asthma Allergy 2015 851-61 (Posted: Jun 10, 2015 3PM)

Copy number variation burden on asthma subgenome in normal cohorts identifies susceptibility markers.
Vishweswaraiah Sangeetha et al. Allergy Asthma Immunol Res 2015 May (3) 265-75 (Posted: May 26, 2015 1PM)

Genetic Variation Along the Histamine Pathway In Children with Allergic vs Non-Allergic Asthma.
Anvari Sara et al. Am. J. Respir. Cell Mol. Biol. 2015 Apr 24. (Posted: May 23, 2015 10AM)

Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity.
Sordillo Joanne E et al. J. Allergy Clin. Immunol. 2015 Apr 24. (Posted: May 23, 2015 10AM)

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels.
Schedel Michaela et al. J. Allergy Clin. Immunol. 2015 Apr 28. (Posted: May 23, 2015 9AM)

GIMAP GTPase Family Genes: Potential Modifiers in Autoimmune Diabetes, Asthma, and Allergy.
Heinonen Mirkka T et al. J. Immunol. 2015 May 11. (Posted: May 23, 2015 9AM)

Effect of ADRB2 (adrenergic receptor ß2) gene polymorphisms on the occurrence of asthma and on the response to nebulized salbutamol in South Indian patients with bronchial asthma.
Shah Neel Jayesh et al. J Asthma 2015 May 19. 1-8 (Posted: May 23, 2015 9AM)

Vitamin D metabolism genes in asthma and atopy.
Morales Eva et al. Mini Rev Med Chem 2015 May 18. (Posted: May 23, 2015 9AM)

Genetic association of key Th1/Th2 pathway candidate genes, IRF2, IL6, IFNGR2, STAT4 and IL4RA, with atopic asthma in the Indian population.
Kumar Amrendra et al. J. Hum. Genet. 2015 May 21. (Posted: May 23, 2015 9AM)

Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome.
Fujimura Kei E et al. Cell Host Microbe 2015 May 13. (5) 592-602 (Posted: May 19, 2015 0PM)

Biomarkers to predict asthma in wheezing preschool children.
Bannier Michiel Age et al. Clin. Exp. Allergy 2014 Nov 20. (Posted: Apr 22, 2015 1PM)

Genetics of allergic diseases.
Ortiz Romina A et al. Immunol Allergy Clin North Am 2015 Feb (1) 19-44 (Posted: Apr 22, 2015 1PM)

Systems biology of asthma and allergic diseases: a multiscale approach.
Bunyavanich Supinda et al. J. Allergy Clin. Immunol. 2015 Jan (1) 31-42 (Posted: Apr 22, 2015 1PM)

Genome-wide association study of short-acting ß2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3.
Israel Elliot et al. Am. J. Respir. Crit. Care Med. 2015 Mar 1. (5) 530-7 (Posted: Apr 22, 2015 1PM)

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.
Gomez Jose L et al. J. Allergy Clin. Immunol. 2015 Jan 12. (Posted: Apr 22, 2015 1PM)

Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma.
Wang Y et al. Pharmacogenomics J. 2015 Jan 20. (Posted: Apr 22, 2015 1PM)

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Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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