Archive
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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Archived Hot Topics of the Day By Date
Infant gut microbiota and environment associate with juvenile idiopathic arthritis many years prior to disease onset, especially in genetically vulnerable children
E Kindgren et al, Ebiomedicine, June 14, 2023
(Posted: Jun 15, 2023 8AM)
Novel genetic loci associated with osteoarthritis in multi-ancestry analyses in the Million Veteran Program and UK Biobank.
McDonald Merry-Lynn N et al. Nature genetics 2022 11
(Posted: Nov 22, 2022 7AM)
Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.
Ishigaki Kazuyoshi et al. Nature genetics 2022 11
(Posted: Nov 06, 2022 8AM)
Provocateurs of autoimmunity within the gut microbiota.
Upadhyay Rabi et al. Science translational medicine 2022 10 (668) eadd3901
(Posted: Oct 27, 2022 9AM)
Do genetics contribute to TNF inhibitor response prediction in Psoriatic Arthritis?
PDK Curry et al, The PGX Journal, October 15, 2022
(Posted: Oct 17, 2022 7AM)
Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate
KH van der Pol et al, EJHG, September 2, 2022
(Posted: Sep 02, 2022 9AM)
Inching closer to precision treatment for rheumatoid arthritis
LT Donlin, Nature Medicine, June 9, 2022
(Posted: Jun 10, 2022 6AM)
Immunogenicity of the third and fourth BNT162b2 mRNA COVID-19 boosters and factors associated with immune response in systemic lupus erythematosus and rheumatoid arthritis patients
T Assawasaksakul et al, MEDRXIV, March 15, 2022
(Posted: Mar 16, 2022 8AM)
Novel insights into the consequences of obesity: a phenotype-wide Mendelian randomization study
C He et al, EJHG January 1, 2022
(Posted: Jan 03, 2022 2PM)
Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US
J Sun et al, JAMA Internal Medicine, December 28, 2021
(Posted: Dec 28, 2021 2PM)
Four Things You Should Know About Arthritis
CDC, October 2021
(Posted: Oct 10, 2021 7AM)
Comparison of an Artificial Intelligence–Enabled Patient Decision Aid vs Educational Material on Decision Quality, Shared Decision-Making, Patient Experience, and Functional Outcomes in Adults With Knee Osteoarthritis
A Randomized Clinical Trial
P Jayakumar et al, JAMA Network Open, February 2021
(Posted: Mar 02, 2021 8AM)
Comparison of an Artificial Intelligence-Enabled Patient Decision Aid vs Educational Material on Decision Quality, Shared Decision-Making, Patient Experience, and Functional Outcomes in Adults With Knee Osteoarthritis: A Randomized Clinical Trial.
Jayakumar Prakash et al. JAMA network open 2021 Feb 4(2) e2037107
(Posted: Feb 23, 2021 9AM)
Using genetics to prioritize diagnoses for rheumatology outpatients with inflammatory arthritis
R Knevel et al, Sci Trans Medicine, May 27, 2020
(Posted: May 28, 2020 7AM)
Cell-Free DNA as a Biomarker in Autoimmune Rheumatic Diseases.
Duvvuri Bhargavi et al. Frontiers in immunology 2019 502
(Posted: May 20, 2019 9AM)
Insights into rheumatic diseases from next-generation sequencing.
Donlin Laura T et al. Nature reviews. Rheumatology 2019 Apr
(Posted: May 20, 2019 9AM)
HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications.
Busch Robert et al. Nature reviews. Rheumatology 2019 May
(Posted: May 20, 2019 9AM)
Physical Activity Helps Arthritis Pain
CDC, May 2019
(Posted: May 20, 2019 9AM)
Arthritis Awareness Month
MMWR, May 2019
(Posted: May 03, 2019 8AM)
Assessment of a Deep Learning Model Based on Electronic Health Record Data to Forecast Clinical Outcomes in Patients With Rheumatoid Arthritis
B Norgeot et al, JAMA Network Open, March 15, 2019
(Posted: Mar 19, 2019 7AM)
Cardiometabolic polygenic risk scores and osteoarthritis outcomes: a Mendelian randomization study from the MalmÓ§ Diet and Cancer Study and the UK Biobank.
Hindy George et al. Arthritis & rheumatology (Hoboken, N.J.) 2019 Jan
(Posted: Jan 09, 2019 9AM)
Prediction of treatment response in rheumatoid arthritis patients using genome-wide SNP data.
Cherlin Svetlana et al. Genetic epidemiology 2018 Oct
(Posted: Oct 28, 2018 8AM)
Breathing New Life into Interstitial Lung Disease in Rheumatoid Arthritis
PK Gergersen et al, NEJM, October 20, 2018
(Posted: Oct 21, 2018 2PM)
Psoriatic arthritis
NIH Genetics Home Reference, 2018
(Posted: Oct 09, 2018 2PM)
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients
MT Patrick et al, Nature Communications, October 9, 2018
(Posted: Oct 09, 2018 2PM)
Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission.
Tasaki Shinya et al. Nature communications 2018 Jul (1) 2755
(Posted: Jul 19, 2018 9AM)
Diagnosis of Osteoarthritis Subtypes with Blood Biomarkers
K Zhao et al, BioRXIV, July 10, 2018
(Posted: Jul 16, 2018 8AM)
The role of genetics and epigenetics in rheumatic diseases: are they really a target to be aimed at?
Kato Masaru et al. Rheumatology international 2018 Apr
(Posted: Jul 10, 2018 8AM)
Disease of the Week: Arthritis
(Posted: Jul 10, 2018 8AM)
Predictors of Treatment Response in Rheumatoid Arthritis.
Lequerré Thierry et al. Joint, bone, spine : revue du rhumatisme 2018 Jul
(Posted: Jul 10, 2018 8AM)
The clinical utility of human leucocyte antigen B27 in axial spondyloarthritis.
Lim Chong Seng Edwin et al. Rheumatology (Oxford, England) 2017 Sep
(Posted: Oct 18, 2017 11AM)
Arthritis in America: Time to Take Action!
(Posted: Mar 08, 2017 10AM)
Update on the genetic architecture of rheumatoid arthritis.
Kim Kwangwoo et al. Nature reviews. Rheumatology 2017 Jan (1) 13-24
(Posted: Mar 08, 2017 10AM)
A clinical update on the significance of the gut microbiota in systemic autoimmunity.
Rosser Elizabeth C et al. Journal of autoimmunity 2016 Jul
(Posted: Aug 23, 2016 9AM)
Cardiovascular risk assessment in patients with rheumatoid arthritis: The relevance of clinical, genetic and serological markers.
López-Mejías Raquel et al. Autoimmunity reviews 2016 Aug
(Posted: Aug 23, 2016 9AM)
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
SK Sieberts et al, Nature Communications, August 23, 2016
(Posted: Aug 23, 2016 9AM)
Gut Bacteria Can Cause, Predict and Prevent Rheumatoid Arthritis
S Rosen, Mayo Clinic Blog, July 12, 2016
(Posted: Jul 13, 2016 6AM)
Genetic Biomarker Search Could Personalize Medicine for Arthritis Sufferers
GEN, Clinical Omics, May 2016
(Posted: May 26, 2016 0AM)
Emerging aspects of molecular biomarkers for diagnosis, prognosis and treatment response in rheumatoid arthritis.
Márquez Ana et al. Expert review of molecular diagnostics 2016 Jun (6) 663-75
(Posted: May 21, 2016 8AM)
Family history of rheumatoid arthritis: an old concept with new developments.
Frisell Thomas et al. Nature reviews. Rheumatology 2016 Apr
(Posted: May 21, 2016 8AM)
Arthritis Across America
(Posted: May 21, 2016 8AM)
Rheumatoid arthritis
(Posted: Apr 30, 2016 0AM)
Genetic data: The new challenge of personalized medicine, insights for rheumatoid arthritis patients.
Goulielmos George N et al. Gene 2016 Jun (2) 90-101
(Posted: Apr 22, 2016 10AM)
Review - Rheumatoid arthritis: What have we learned about the causing factors?
Jalil Syed Fazal et al. Pakistan journal of pharmaceutical sciences 2016 Mar (2) 629-45
(Posted: Apr 22, 2016 10AM)
Arthritis on the Rise
(Posted: Apr 22, 2016 10AM)
Genetic, Epigenetic and Pharmacogenetic Aspects of Psoriasis and Psoriatic Arthritis.
O'Rielly Darren D et al. Rheumatic diseases clinics of North America 2015 Nov (4) 623-42
(Posted: Oct 20, 2015 8PM)
Role of genetics in infection-associated arthritis.
Benham Helen et al. Best practice & research. Clinical rheumatology 2015 Apr (2) 213-25
(Posted: Oct 15, 2015 6PM)
Genetics of ankylosing spondylitis-insights into pathogenesis.
Brown Matthew A et al. Nature reviews. Rheumatology 2015 Oct
(Posted: Oct 15, 2015 6PM)
From genetics to functional insights into rheumatoid arthritis.
Suzuki Akari et al. Clinical and experimental rheumatology 2015 Oct
(Posted: Oct 15, 2015 6PM)
Germs and joints: the contribution of the human microbiome to rheumatoid arthritis
Geraint B Rogers, Nature Medicine, August 6, 2015
(Posted: Aug 07, 2015 9AM)
Comprehensive review of genetic association studies and meta-analysis on miRNA polymorphisms and rheumatoid arthritis and systemic lupus erythematosus susceptibility.
Fu Lingyu et al. Hum. Immunol. 2014 Sep 11.
(Posted: Jul 20, 2015 1PM)
Does a family history of RA influence the clinical presentation and treatment response in RA?
Frisell Thomas et al. Ann. Rheum. Dis. 2015 Jun 19.
(Posted: Jun 24, 2015 1PM)
Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.
Bowes John et al. Nat Commun 2015 6046
(Posted: May 05, 2015 10AM)
PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.
Bowes John et al. Ann. Rheum. Dis. 2015 Apr 28.
(Posted: May 05, 2015 10AM)
RA Treatment Response Influenced by HLA-DRB1 Haplotype
JC Kelly, Medscape, Apr 28 [by free subscription only]
(Posted: Apr 29, 2015 10AM)
Genetic contribution of DKK-1 polymorphisms to RA structural severity and DKK-1 level of expression.
Miceli-Richard Corinne et al. Ann. Rheum. Dis. 2015 Mar 24.
(Posted: Apr 28, 2015 7PM)
FcGR genetic polymorphisms and the response to adalimumab in patients with rheumatoid arthritis.
Dávila-Fajardo Cristina Lucía et al. Pharmacogenomics 2015 Mar (4) 373-81
(Posted: Apr 28, 2015 7PM)
Variation at FCGR2A and Functionally Related Genes Is Associated with the Response to Anti-TNF Therapy in Rheumatoid Arthritis.
Avila-Pedretti Gabriela et al. PLoS ONE 2015 (4) e0122088
(Posted: Apr 28, 2015 7PM)
Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study.
Canet Luz M et al. Pharmacogenet. Genomics 2015 Apr 4.
(Posted: Apr 28, 2015 7PM)
A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis.
Julià A et al. Pharmacogenomics J. 2015 Apr 21.
(Posted: Apr 28, 2015 7PM)
Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis.
Ferreiro-Iglesias A et al. Pharmacogenomics J. 2015 Apr 21.
(Posted: Apr 28, 2015 7PM)
Human leukocyte antigen polymorphisms and personalized medicine for rheumatoid arthritis.
Furukawa Hiroshi et al. J. Hum. Genet. 2015 Apr 23.
(Posted: Apr 28, 2015 7PM)
Genetic architectures of seropositive and seronegative rheumatic diseases.
Kirino Yohei et al. Nat Rev Rheumatol 2015 Apr 28.
(Posted: Apr 28, 2015 7PM)
Association of HLA-DRB1 Haplotypes With Rheumatoid Arthritis Severity, Mortality, and Treatment Response
S Viatte et al. JAMA, April 28, 2015
(Posted: Apr 28, 2015 7PM)
Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity.
Bramwell Kenneth K C et al. Front Cell Infect Microbiol 2014 76
(Posted: Mar 27, 2015 5PM)
To what extent is the familial risk of rheumatoid arthritis explained by established rheumatoid arthritis risk factors?
Jiang Xia et al. Arthritis & rheumatology (Hoboken, N.J.) 2015 Feb (2) 352-62
(Posted: Feb 12, 2015 8AM)
Stress Testing
From NHLBI health topic site
(Posted: Jan 01, 2014 0AM)
Sarcoidosis
From NHLBI health topic site
(Posted: Jan 01, 2014 0AM)
Restless Legs Syndrome
From NHLBI health topic site
(Posted: Jan 01, 2014 0AM)
Arthritis short stature deafness
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Pauciarticular chronic arthritis
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Reactive arthritis
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Infectious arthritis
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Pyogenic arthritis, pyoderma gangrenosum and acne
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Leukoencephalopathy, arthritis, colitis, and hypogammaglobulinema
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Systemic onset juvenile idiopathic arthritis
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Polyarticular onset juvenile idiopathic arthritis
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Pauciarticular onset juvenile idiopathic arthritis
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Enthesitis-related juvenile idiopathic arthritis
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Psoriatic juvenile idiopathic arthritis
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
- Page last updated:Mar 27, 2024
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