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COVID-19 GPH|Home|PHGKB Last data update: Dec 03, 2021 . (Total: 28426 Documents since 2020)

Last Posted: Dec-03-2021 12:11:40
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Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals
B Grunau et al, JAMA, December 3, 2021

Longer mRNA vaccine dosing intervals demonstrated improved immunogenicity, which was consistent when responses were measured based on timing of the first or second dose. These data suggest that extending dosing intervals may be particularly advantageous against the Delta variant. A delayed second-dose strategy could yield faster partial protection to a larger proportion of the population when vaccine supplies are limited.

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
RR Goel et al, Science, December 3, 2021

The study examined B and T lymphocyte responses in individuals who received SARS-CoV-2 messenger RNA vaccines. They performed a 6-month longitudinal study of individuals who never had SARS-CoV-2 infection compared with people who had recovered from SARS-CoV-2. Humoral and cellular immune memory was observed in vaccinated individuals, as were functional immune responses against the Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617.2) viral variants. Analysis of T cell activity suggested that robust cellular immune memory may prevent hospitalization by limiting the development of severe disease.

Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic
SSA Karim, The Lancet, December 3, 2021

The principal concerns about omicron include whether it is more infectious or severe than other VoCs and whether it can circumvent vaccine protection. Extrapolations based on known mutations and preliminary observations, which should be interpreted with caution, indicate that omicron might spread faster and might escape antibodies more readily than previous variants, thereby increasing cases of reinfection and cases of mild breakthrough infections in people who are vaccinated.

Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa
JRC Pulliam et al, MEDRXIV, December 2, 2021

Population-level evidence suggests that the Omicron variant is associated with substantial ability to evade immunity from prior infection. In contrast, there is no population-wide epidemiological evidence of immune escape associated with the Beta or Delta variants. This finding has important implications for public health planning, particularly in countries like South Africa with high rates of immunity from prior infection.

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Data Emerge From the UK’s COVID-19 Vaccine Extended Dosing Interval
J Abbasi, JAMA, December 3, 2021

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‘Just stupid stuff’: Logistics and lack of testing stymied finding the Omicron variant in the U.S.
M Molteni, Stat News, December 2, 2021

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Changes Over Time in COVID-19 Vaccination Inequalities in Eight Large U.S. Cities
SM Gaddis et al, MEDRXIV, December 2, 2021

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Evaluating COVID-19 booster vaccination strategies in a partially vaccinated population: a modeling study.
CR Massonaud et al, MEDRXIV, December 2, 2021

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Estimating the increase in reproduction number associated with the Delta variant using local area dynamics in England
S Abbot et al, MEDRXIV, December 2, 2021

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Comparison of Saliva and Mid-Turbinate Swabs for Detection of COVID-19
J Lai et al, MEDRXIV, December 2, 2021

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Reducing persistently positive SARS-CoV-2 diagnoses using long-range RT-qPCR
AJW de Velthuis et al, MEDRXIV, December 2, 2021

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Third COVID-19 Vaccine Dose Boosts Neutralising Antibodies in Poor Responders
D Lake et al, MEDRXIV, December 2, 2021

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Managing the Digital Disruption Associated with COVID-19-Driven Rapid Digital Transformation in Brisbane, Australia.
Dyda Amalie, et al. Applied clinical informatics 2021 0 0. (5) 1135-1143

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Deep learning-based exchange rate prediction during the COVID-19 pandemic.
Abedin Mohammad Zoynul, et al. Annals of operations research 2021 0 0. 1-52

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About COVID-19 GPH

COVID-19 GPH is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that captures emerging discoveries and applications of genomics, molecular and other precision medicine and precision public health tools in the investigation and control of COVID-19. Contents include PubMed records via an automated pubmed search algorithm, preprint records from NIH iCite, the relevant information from many media sources picked by experts, and linkages to contents from our curated PHGKB databases.
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All Records28426
Genomics Precision Health20159
Non-Genomics Precision Health8267

Publication Categories Brand

Mechanism 5673
Treatment 5229
Vaccines 5139
Variants 4829
Diagnosis 3833
Prevention 3444
Forecasting 2296
Surveillance 2148
Transmission 1190
Health Equity 725

Publication Types

PubMed Records20650
Online News/Reports/Publications551

Genomics Precision Health (GPH): The use of pathogen and human genomics and advanced molecular detection methods in discovery, clinical and public health investigations and response to COVID-19.
Non Genomics Precision Health (non-GPH): The use of big data, data science, digital health, machine learning and predictive analytic methods (not involving genomics) in discovery, clinical and public health investigations and response to COVID-19

Following categories are annotated by LitCovid from NCBI NIH.
MechanismUnderlying cause(s) of covid-19 infections and transmission & possible drug mechanism of action
Transmission Characteristics and modes of covid-19 transmissions, such as human-to-human
DiagnosisDisease assessment through symptoms, test results, and radiological features
PreventionPrevention, control, response and management strategies
Case ReportDescriptions of specific patient cases
ForecastingModelling and estimating the trend of covid-19 spread

Following categories are annotated by the text mining tool from CDC PHGKB
Health EquityRelevant to health equity. Search terms are derived from a list provided by the Association for Territorial Health Officials which include terms such as diversity, health disparities, and others.
VaccineRelevant to vaccine development, evaluation, implementation and impact. For additional information on vaccines and COVID-19. Check out general CDC Information pages
VariantRelevant to SARS-CoV-2 variants and their impact on public health. For additional information on variants COVID-19. Check out CDC New Variants of the Virus that Causes COVID-19 page
SurveillanceRelevant to SARS-CoV-2 public health surveillance and tracking. For additional information on COVID-19 surveillance, check out CDC COVID-19 Data Tracker

Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.