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COVID-10 GPH

COVID-19 GPH|Home|PHGKB Last data update: Aug 04, 2021 . (Total: 23643 Documents since 2020)
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Last Posted: Aug-04-2021 18:12:53
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SARS-CoV-2 Variants in Patients with Immunosuppression
L Corey et al, NEJM, August 5, 2021

The findings that immunocompromised patients with persistent SARS-CoV-2 infection may generate more transmissible or more pathogenic SARS-CoV-2 variants have a number of medical and public health implications. Heightened precautions should be taken to avert nosocomial transmission of Covid-19 among immunocompromised patients.

Fundamentals of Public Health — A New Perspective Series
BR Bloom et al, NEJM, August 5, 2021

The Covid-19 pandemic has awakened many physicians to the value of viewing wellness and disease through the lens of public health as well as that of clinical medicine. To help foster such a reframing, we are launching in this issue of the Journal a Perspective series entitled “Fundamentals of Public Health.”

Myocarditis and Pericarditis After Vaccination for COVID-19
GA Diaz et al, JAMA, August 4, 2021

Forty hospitals in Washington, Oregon, Montana, and Los Angeles County, California, that were part of the Providence health care system and used the same electronic medical record (EMR) were included. All patients with documented COVID-19 vaccinations administered inside the system or recorded in state registries at any time through May 25, 2021, were identified. Two distinct self-limited syndromes, myocarditis and pericarditis, were observed after COVID-19 vaccination. Myocarditis developed rapidly in younger patients, mostly after the second vaccination. Pericarditis affected older patients later, after either the first or second dose.

A worldwide assessment of changes in adherence to COVID-19 protective behaviours and hypothesized pandemic fatigue
A Petherick et al, Nat Hum Behavior, August 3, 2021

Our results show that changes in adherence were empirically meaningful and geographically widespread. While a low-cost and habituating behaviour (mask wearing) exhibited a linear rise in adherence, high-cost and sensitizing behaviours (physical distancing) declined, but this decline decelerated over time, with small rebounds seen in later months. Reductions in adherence to physical distancing showed little difference across societal groups, but were less intense in countries with high interpersonal trust. Alternative underlying mechanisms and policy implications are discussed.


news Latest News and Publications
The delta variant is surging. How should that change how we live?
LS Wen, Washington Post, August 4, 2021

Is the Delta Variant Making Younger Adults ‘Sicker, Quicker’? Many doctors on the front lines say unvaccinated patients in their 20s and 30s are becoming more severely ill, and more quickly. But comprehensive data is lacking.
RC Rabin, NY Times, August 4, 2021

After Months as a Covid Success Story, China Tries to Tame Delta- The government has imposed lockdowns and is testing and tracing aggressively to fight a new outbreak. Experts say it is time for the country to rethink its approach to the virus.
SL Wee et al, NY Times, August 4, 2021

Lambda Variant Shows Vaccine Resistance
Medscape, August 3, 2021

Will the Delta Variant Peak and Then Burn Out?
K Doheny, Medscape, August 4, 2021

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About COVID-19 GPH

COVID-19 GPH is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other materials that captures emerging discoveries and applications of genomics, molecular and other precision medicine and precision public health tools in the investigation and control of COVID-19. Contents include PubMed records via an automated pubmed search algorithm, preprint records from NIH iCite, the relevant information from many media sources picked by experts, and linkages to contents from our curated PHGKB databases.
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Summary

All Records23643
Genomics Precision Health16866
Non-Genomics Precision Health6777

Special Topics

Publication Categories Brand

Mechanism 4362
Treatment 3973
Vaccine 3891
Variant 3402
Diagnosis 2847
Prevention 2826
Forecasting 1899
Surveillance 1735
Transmission 933
Health Equity 616
Case Report 462

Publication Types

PubMed Records17219
Preprints5966
Online News/Reports/Publications450

In PHGKB Databases

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Genomics Precision Health (GPH): The use of pathogen and human genomics and advanced molecular detection methods in discovery, clinical and public health investigations and response to COVID-19.
Non Genomics Precision Health (non-GPH): The use of big data, data science, digital health, machine learning and predictive analytic methods (not involving genomics) in discovery, clinical and public health investigations and response to COVID-19

Following categories are annotated by LitCovid from NCBI NIH.
MechanismUnderlying cause(s) of covid-19 infections and transmission & possible drug mechanism of action
Transmission Characteristics and modes of covid-19 transmissions, such as human-to-human
DiagnosisDisease assessment through symptoms, test results, and radiological features
PreventionPrevention, control, response and management strategies
Case ReportDescriptions of specific patient cases
ForecastingModelling and estimating the trend of covid-19 spread

Following categories are annotated by the text mining tool from CDC PHGKB
Health EquityRelevant to health equity. Search terms are derived from a list provided by the Association for Territorial Health Officials which include terms such as diversity, health disparities, and others.
VaccineRelevant to vaccine development, evaluation, implementation and impact. For additional information on vaccines and COVID-19. Check out general CDC Information pages
VariantRelevant to SARS-CoV-2 variants and their impact on public health. For additional information on variants COVID-19. Check out CDC New Variants of the Virus that Causes COVID-19 page
SurveillanceRelevant to SARS-CoV-2 public health surveillance and tracking. For additional information on COVID-19 surveillance, check out CDC COVID-19 Data Tracker

Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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