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COVID-10 GPH

Rare Diseases|COVID-19 GPH|PHGKB

Rare Diseases and COVID-19

Last Update: May 17, 2022

This section lists all rare diseases, many of which are genetic diseases, that have been connected to COVID-19 in the literature. There are 507 diseases/conditions from the list of nearly 7,000 rare diseases extracted from the NIH website that are related to COVID-19 literature or news and reports. Click on the number after each disease term to retrieve COVID-19 related articles. To obtain more information about each disease, click the link on the disease term that leads to the Rare Disease PHGKB.

Disease Term No.Publication in COVID-19 GPH
21-hydroxylase deficiency 1
22q11.2 deletion syndrome 2
Abdominal aortic aneurysm 1
Acquired hemophilia 7
Acquired hemophilia A 7
Acquired Von Willebrand syndrome 2
Acromegaly 1
Acute disseminated encephalomyelitis 5
Acute flaccid myelitis 1
Acute graft versus host disease 1
Acute intermittent porphyria 1
Acute interstitial pneumonia 3
Acute lymphoblastic leukemia 5
Acute mountain sickness 1
Acute myeloid leukemia 3
Acute myelomonocytic leukemia 1
Acute necrotizing encephalopathy 3
Acute promyelocytic leukemia 2
Addison's disease 1
Adenoid cystic carcinoma 1
Adie syndrome 1
Adult T-cell leukemia/lymphoma 1
Adult-onset Still's disease 2
Agnosia 1
Aicardi-Goutieres syndrome 1
AIDS Dementia Complex 1
Allergic bronchopulmonary aspergillosis 1
Alpha-1 antitrypsin deficiency 7
Alveolar capillary dysplasia 1
Amebiasis 1
Aminoaciduria 1
Amyopathic dermatomyositis 1
Amyotrophic lateral sclerosis 11
Anaplastic large cell lymphoma 1
Anaplastic thyroid cancer 1
ANCA-associated vasculitis 3
Anencephaly 1
Angelman syndrome 1
Aniridia 1
Anterior uveitis 1
Anthrax 3
Antiphospholipid syndrome 6
Aortic coarctation 1
Aortic valve stenosis 1
Aphthous stomatitis 1
Aplastic anemia 1
Apraxia 1
Aspergillosis 21
Ataxia telangiectasia 3
Atrioventricular septal defect 1
Atypical hemolytic uremic syndrome 25
Autoimmune encephalitis 1
Autoimmune hemolytic anemia 1
Autoimmune hepatitis 2
Autoimmune lymphoproliferative syndrome 1
Autoimmune pancreatitis 1
Autoimmune pulmonary alveolar proteinosis 2
Autoimmune retinopathy 1
Autosomal recessive hyper IgE syndrome 1
Bacterial meningitis 1
Bartter syndrome 1
B-cell lymphoma 4
Becker muscular dystrophy 2
Behçet disease 1
Bell's palsy 7
Benign paroxysmal positional vertigo 1
Beta-thalassemia 10
Biliary atresia 1
Biotin-thiamine-responsive basal ganglia disease 1
BK-virus nephropathy 1
Blastic plasmacytoid dendritic cell 1
Blastomycosis 1
Bronchogenic cyst 1
Bronchopulmonary dysplasia 3
Brucellosis 2
Brugada syndrome 11
Brugada syndrome 3 11
Brugada syndrome 4 11
Bubonic plague 3
Budd-Chiari syndrome 2
Bullous pemphigoid 1
Burkitt lymphoma 1
Byssinosis 1
C syndrome 6949
Calciphylaxis 1
Candida glabrata 1
Castleman disease 1
Catastrophic antiphospholipid syndrome 3
Catecholaminergic polymorphic ventricular tachycardia 2
CD4 deficiency 1
Cerebral palsy 2
Cerebrospinal fluid leak 1
Cervical intraepithelial neoplasia 1
Charcot-Marie-Tooth disease 1
Chikungunya 19
Cholecystitis 6
Cholera 10
Cholesteatoma 1
Chorioretinitis 2
Chronic graft versus host disease 1
Chronic granulomatous disease 1
Chronic inflammatory demyelinating polyneuropathy 1
Chronic lymphocytic leukemia 13
Chronic myeloid leukemia 5
Chronic myelomonocytic leukemia 2
Chronic thromboembolic pulmonary hypertension 1
Clear cell renal cell carcinoma 3
Coccidioidomycosis 1
Cogan's syndrome 1
Cold agglutinin disease 1
Common variable immunodeficiency 43
Compartment syndrome 1
Congenital adrenal hyperplasia 1
Congenital diaphragmatic hernia 1
Congenital generalized lipodystrophy type 1 1
Congenital generalized lipodystrophy type 2 1
Congenital generalized lipodystrophy type 3 1
Congenital generalized lipodystrophy type 4 1
Congenital myasthenic syndrome 1
Cornelia de Lange syndrome 1
Coronary artery aneurysm 1
Cough headache 6
Craniosynostosis 1
Creutzfeldt-Jakob disease 2
Cryoglobulinemia 1
Cryopyrin-associated periodic syndrome 1
Cryptococcosis 1
Cryptogenic organizing pneumonia 1
Cryptosporidiosis 1
Cushing's syndrome 1
Cutaneous lupus erythematosus 1
Cutaneous mastocytosis 1
Cutaneous T-cell lymphoma 2
Cyclic neutropenia 1
Cystic fibrosis 147
Cysticercosis 1
Cystinosis 1
Cystinuria 1
Dengue fever 14
Dermatomyositis 8
Diffuse Large B-Cell Lymphoma 1
Dilated cardiomyopathy 8
Diphtheria 3
Dravet syndrome 1
Duchenne muscular dystrophy 12
Dyskeratosis congenita 2
Dystrophic epidermolysis bullosa 1
EAF 1
Ebola virus disease 11
Eclampsia 4
Ectodermal dysplasia 2
Ectopic pregnancy 1
Ectropion inferior cleft lip and or palate 3
Ehlers-Danlos syndromes 1
Ellis-Van Creveld syndrome 1
Emery-Dreifuss muscular dystrophy 1
Eosinophilic granulomatosis with polyangiitis 2
Epidermolysis bullosa 1
Erythema elevatum diutinum 1
Erythema multiforme 6
Esophageal cancer 1
Essential thrombocythemia 1
Evans syndrome 1
Fabry disease 9
Facioscapulohumeral muscular dystrophy 1
Factor 2 deficiency 2
Factor V deficiency 2
Factor X deficiency 2
Familial Mediterranean fever 27
Fanconi anemia 1
Fanconi syndrome 1
Fibrodysplasia ossificans progressiva 3
Focal or multifocal malformations in neuronal migration 50
Focal segmental glomerulosclerosis 4
Follicular lymphoma 1
Fragile X syndrome 2
Frontotemporal dementia 3
GATA2 deficiency 1
Gaucher disease 10
Generalized pustular psoriasis 1
Giant cell arteritis 1
Giant cell myocarditis 1
Gitelman syndrome 4
Glioblastoma 6
Glioma 3
Glomerulonephritis 6
Glucose-6-phosphate dehydrogenase deficiency 5
Granuloma annulare 2
Granulomatosis with polyangiitis 4
Graves' disease 2
Growth hormone deficiency 1
Guillain-Barre syndrome 9
Guttate psoriasis 1
Haemophilus influenzae 4
Hairy cell leukemia 2
Hansen's disease 3
Hantavirus pulmonary syndrome 1
Hartnup disease 1
HELLP syndrome 1
Hemiplegia 1
Hemoglobin C disease 1
Hemoglobin E disease 1
Hemolytic uremic syndrome 26
Hemophagocytic lymphohistiocytosis 23
Hemophilia 20
Hemophilia A 20
Hemophilia B 20
Hemophilic arthropathy 1
Hemorrhagic fever 4
Heparin-induced thrombocytopenia 3
Hepatitis E 163
Hepatoblastoma 1
Hepatopulmonary syndrome 1
Hereditary angioedema 26
Hereditary ataxia 1
Hereditary coproporphyria 1
Hereditary fructose intolerance 3
Hereditary hemorrhagic telangiectasia 9
Hereditary spastic paraplegia 2
Hereditary spherocytosis 2
Herpes simplex encephalitis 2
Herpes zoster ophthalmicus 1
Hirschsprung's disease 1
Hodgkin lymphoma 6
Homocysteinemia 1
Huntington disease 2
Hydatidiform mole 1
Hydrocephalus 1
Hydrops fetalis 1
Hyper IgE syndrome 1
Hypereosinophilic syndrome 5
Hypersensitivity pneumonitis 3
Hypoadrenalism 1
Hypohidrotic ectodermal dysplasia 1
Hypoparathyroidism 2
Hypopituitarism 2
Hypothalamic dysfunction 1
I cell disease 31
Idiopathic pulmonary fibrosis 32
IgA nephropathy 2
IgG4-related disease 1
Immune thrombocytopenia 4
Immunoglobulin A deficiency 2 2
Inclusion body myositis 1
Incontinentia pigmenti 1
Indolent B cell lymphoma 1
Intrahepatic cholangiocarcinoma 1
Intrauterine infections 3
Japanese encephalitis 6
Juvenile dermatomyositis 2
Juvenile myelomonocytic leukemia 1
Kaposi sarcoma 1
Kawasaki disease 40
Keratoconus 1
Kuru 1
Lambert Eaton myasthenic syndrome 1
Legionellosis 1
Leishmaniasis 3
Lennox-Gastaut syndrome 1
Leptospirosis 1
Leukocyte adhesion deficiency type 1 1
Leukoplakia 1
Ligneous conjunctivitis 1
Limb-girdle muscular dystrophy 2
Limbic encephalitis 1
Livedoid vasculopathy 1
Locked-in syndrome 1
Loiasis 1
Long QT syndrome 1 15
Long QT syndrome 2 15
Long QT syndrome 3 15
Long QT syndrome 4 15
Long QT syndrome 5 15
Long QT syndrome 6 15
Long QT syndrome 9 15
Lung adenocarcinoma 43
Lupus nephritis 3
Lymphangioleiomyomatosis 2
Lymphatic filariasis 1
Lymphocytic vasculitis 1
Lymphogranuloma venereum 2
Macroglossia 1
Macrophage activation syndrome 23
Malaria 97
Malignant hyperthermia 2
Mantle cell lymphoma 1
Marburg hemorrhagic fever 1
Marfan syndrome 2
Marginal zone lymphoma 1
Mast cell activation syndrome 1
Mastocytosis 3
Measles 52
Melioidosis 1
Membranoproliferative glomerulonephritis 1
Membranous nephropathy 1
Meningococcal infection 1
Mercury poisoning 1
Methylmalonic acidemia 1
Microcephaly 3
Microphthalmia 1
Microscopic polyangiitis 1
Miller-Fisher syndrome 14
Minimal change disease 1
Mixed connective tissue disease 1
Monkeypox 2
Monoclonal gammopathy of undetermined significance 1
Moyamoya disease 1
Mucopolysaccharidosis 2
Multiple myeloma 14
Mumps 14
Muscular dystrophy 19
Myasthenia gravis 10
Mycobacterium Avium Complex 2
Mycosis fungoides 1
Myelitis 5
Myelodysplastic syndromes 2
Myelofibrosis 1
Myeloid leukemia 9
Myocarditis 134
Myotonic dystrophy 2
Myotonic dystrophy type 1 1
N syndrome 6949
Narcolepsy 1
Nasopharyngeal carcinoma 1
Necrotizing enterocolitis 1
Necrotizing fasciitis 1
Neisseria meningitidis infection 1
Neonatal herpes 1
Neuroblastoma 3
Neuroendocrine tumor 1
Neurofibromatosis 3
Neurofibromatosis type 1 1
Neurofibromatosis type 2 1
Neuroleptic malignant syndrome 1
Neuromyelitis optica 10
Neuromyelitis optica spectrum disorder 3
Neurosyphilis 1
Niemann-Pick disease 1
Nodular melanoma 1
Noma 1
Onchocerciasis 1
Optic atrophy 1 1
Optic neuritis 3
Oral cancer 1
Oral leukoplakia 1
Oral squamous cell carcinoma 1
Oral submucous fibrosis 1
Osteogenesis imperfecta 1
Osteomalacia 1
Osteomyelitis 1
Osteosarcoma 1
Ovarian cancer 11
Pachygyria 1
Pancreatic neuroendocrine tumor 1
PANDAS 2
Panuveitis 1
Papilledema 1
Paracoccidioidomycosis 1
Paragangliomas 1 1
Paragangliomas 2 1
Paragangliomas 3 1
Paragangliomas 4 1
Parainfluenza virus type 3 2
Paraplegia 2
Paroxysmal nocturnal hemoglobinuria 1
Parsonage Turner syndrome 1
Patent ductus arteriosus 1
Pediatric Crohn's disease 1
Pellagra 2
Pemphigus 2
Pemphigus foliaceus 1
Pemphigus vulgaris 1
Periodic fever, aphthous stomatitis, pharyngitis and adenitis 1
Perniosis 4
Phenylketonuria 2
Pheochromocytoma 1
Pick's disease 1
Poikiloderma with neutropenia 1
Poliomyelitis 3
Polycythemia vera 1
Polydactyly 1
Polymyositis 1
Pontocerebellar hypoplasia 1
Pontocerebellar hypoplasia type 1 1
Pontocerebellar hypoplasia type 2 1
Pontocerebellar hypoplasia type 3 1
Pontocerebellar hypoplasia type 4 1
Pontocerebellar hypoplasia type 5 1
Pontocerebellar hypoplasia type 6 1
Porphyria 8
Porphyria cutanea tarda 1
Prader-Willi syndrome 4
Precocious puberty 1
Priapism 1
Primary biliary cholangitis 1
Primary ciliary dyskinesia 1
Progeria 1
Progressive multifocal leukoencephalopathy 1
Progressive supranuclear palsy 1
Propionic acidemia 1
Protein R deficiency 1
Protein S deficiency 1
Pseudotumor cerebri 1
Psittacosis 1
Pulmonary arterial hypertension 8
Pustular psoriasis 1
Pyoderma gangrenosum 1
Pyruvate kinase deficiency 1
Q fever 648
Rabies 22
Radiation induced cancer 1
Renal cell carcinoma 4
Renal cell carcinoma 4 4
Retinitis pigmentosa 2
Retinoblastoma 1
Retinopathy of prematurity 6
Reversible cerebral vasoconstriction syndrome 1
Reye syndrome 1
Rheumatic Fever 1
Rickets 1
Rubella 15
Sakati syndrome 1
Schistosomiasis 4
Schwannomatosis 2
Senior Loken Syndrome 1
Severe combined immunodeficiency 4
Short bowel syndrome 1
Shwachman-Diamond syndrome 1
Sickle cell anemia 6
Silicosis 1
Simian B virus infection 1
Sinonasal undifferentiated carcinoma 1
Sixth nerve palsy 1
Smallpox 24
Sotos syndrome 1
Spastic paraplegia 1 2
Spastic paraplegia 2 2
Spastic paraplegia 3 2
Spastic paraplegia 4 2
Spastic paraplegia 6 2
Spastic paraplegia 7 2
Spastic paraplegia 8 2
Spastic paraplegia 9 2
Specific antibody deficiency 2
Spina bifida 1
Spinal muscular atrophy 3
Spinal muscular atrophy 1 3
Spinocerebellar ataxia 1
Splenomegaly 4
Spontaneous coronary artery dissection 1
Staphylococcal toxic shock syndrome 1
Status epilepticus 3
Stevens-Johnson syndrome 1
Stiff person syndrome 1
STING-associated vasculopathy with onset in infancy 1
Stomach cancer 1
Storm syndrome 29
Strongyloidiasis 1
Subacute sclerosing panencephalitis 1
Sudden infant death syndrome 1
Sudden sensorineural hearing loss 1
Systemic onset juvenile idiopathic arthritis 1
Testicular cancer 2
Tetanus 10
Tetralogy of Fallot 3
Thalassemia 34
Thrombocytopenia 2 51
Tick paralysis 1
Tick-borne encephalitis 1
Toxic epidermal necrolysis 2
Transverse myelitis 3
Tricuspid atresia 1
Trigeminal neuralgia 1
Tuberculosis 183
Tuberculous meningitis 1
Tuberous sclerosis 1
Tularemia 1
Turner syndrome 1
Typhoid fever 1
Typhus 4
Tyrosinemia type 1 1
Tyrosinemia type 2 1
Tyrosinemia type 3 1
Usher syndrome 1
Uterine Carcinosarcoma 2
Vaginal cancer 1
Venezuelan equine encephalitis 3
Vernal keratoconjunctivitis 1
Viral hemorrhagic fever 1
Vulvar cancer 1
WAGR syndrome 1
Wernicke-Korsakoff syndrome 1
West nile virus 8
WHIM syndrome 2
Whooping cough 1
Wilms' tumor 1
Wilson disease 1
Wiskott Aldrich syndrome 2
X-linked agammaglobulinemia 21
X-linked intellectual disability with or without nystagmus 1
X-linked lymphoproliferative syndrome 1
X-linked lymphoproliferative syndrome 1 1
X-linked lymphoproliferative syndrome 2 1
X-linked severe combined immunodeficiency 1
Yaws 2
Yellow fever 13
Zika virus infection 1
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