Records 1-30 (of 67 Records) |
Query Trace: TLR3[original query] |
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Lipin-2 regulates the antiviral and anti-inflammatory responses to interferon. de Pablo Nagore, et al. EMBO reports 2023 0 0. e57238 |
Adverse effect of VEGFR-2 (rs1870377) polymorphism on the clinical course of COVID-19 in females and males in an age-dependent manner. Sayin Kocakap Derya Beyza, et al. Microbes and infection 2023 0 0. 105188 |
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Daniela Matuozzo et al. Genome medicine 2023 4 (1) 22
We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P?=?1.1?×?10-4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR?=?3.70[95%CI 1.3–8.2], P?=?2.1?×?10-4).
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Mining the potential therapeutic targets for COVID-19 infection in patients with severe burn injuries via bioinformatics analysis. Cai Xueyao, et al. International wound journal 2023 0 0. |
Altered expression of DNA methyltransferases and methylation status of the TLR4 and TNF-α promoters in COVID-19. Salem Sohair, et al. Archives of virology 2023 0 0. (3) 95 |
SARS-CoV-2 Variant-Specific mRNA Vaccine: Pros and Cons. Shahsavandi Shahla, et al. Viral immunology 2023 0 0. |
SARS-CoV-2 NSP7 inhibits type I and III IFN production by targeting the RIG-I/MDA5, TRIF, and STING signaling pathways. Deng Jian, et al. Journal of medical virology 2023 0 0. |
Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19. Dieter Cristine, et al. Genes 2023 0 0. (1) |
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Matuozzo Daniela, et al. medRxiv : the preprint server for health sciences 2022 0 0. |
Immunoinformatics-Based Identification of B and T Cell Epitopes in RNA-Dependent RNA Polymerase of SARS-CoV-2. Mir Shabir Ahmad, et al. Vaccines 2022 0 0. (10) |
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19 D Matuozo et al, MEDRXIV, October 25, 2022
We report here a genome-wide rare variant burden association analysis in 3,269 unvaccinated patients with life-threatening COVID-19 (1,301 previously reported and 1,968 new patients), and 1,373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI:1.5-528.7, P=1.1x10-4), in analyses restricted to biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70 [95%CI:1.3-8.2], P=2.1x10-4).
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Exploiting reverse vaccinology approach for the design of a multiepitope subunit vaccine against the major SARS-CoV-2 variants. Campos Daniel Melo de Oliveira, et al. Computational biology and chemistry 2022 0 0. 107754 |
Identification of vaccine candidate against Omicron variant of SARS-CoV-2 using immunoinformatic approaches. Aasim, et al. In silico pharmacology 2022 0 0. (1) 12 |
Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes. Lesseur Corina, et al. Placenta 2022 0 0. 125-132 |
Rare Variants in Inborn Errors of Immunity Genes Associated With Covid-19 Severity. Liu Panhong, et al. Frontiers in cellular and infection microbiology 2022 0 0. 888582 |
Genetic and Clinical Characteristics of Patients in the Middle East With Multisystem Inflammatory Syndrome in Children. Abuhammour Walid, et al. JAMA network open 2022 0 0. (5) e2214985 |
Host genetic basis of COVID-19: from methodologies to genes. Zguro Kristina, et al. European journal of human genetics : EJHG 2022 0 0. |
No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination. Lu-Culligan Alice, et al. PLoS biology 2022 0 0. (5) e3001506 |
Host genetic basis of COVID-19: from methodologies to genes K Zguro et al, EJHG, May 27, 2022
This review delineates GWAS and Burden test as traditional methodologies employed so far for the discovery of the human genetic basis of COVID-19, with particular attention to recently emerged predictive models such as the post-Mendelian model. A summary table with the main genome-wide significant genomic loci is provided. Besides, various common and rare variants identified in genes like TLR7, CFTR, ACE2, TMPRSS2, TLR3, and SELP are further described in detail to illustrate their association with disease severity.
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mRNA expression of toll-like receptors 3, 7, 8, and 9 in the nasopharyngeal epithelial cells of coronavirus disease 2019 patients. Bagheri-Hosseinabadi Zahra, et al. BMC infectious diseases 2022 0 0. (1) 448 |
Individual Genetic Variability Mainly of Proinflammatory Cytokines, Cytokine Receptors and Toll-like receptors Dictates Pathophysiology of COVID-19 Disease. Vakil Mohammad Kazem, et al. Journal of medical virology 2022 0 0. |
Severe COVID-19 represents an undiagnosed primary immunodeficiency in a high proportion of infected individuals. Gray Paul E, et al. Clinical & translational immunology 2022 0 0. (4) e1365 |
Epitope Identification and Designing a Potent Multi-epitope Vaccine Construct against SARS-CoV-2 Including the Emerging Variants. Srinivasan Sivasubramanian, et al. Journal of global infectious diseases 2022 0 0. (1) 24-30 |
A protein vaccine with Alum/c-GAMP/poly(I:C) rapidly boosts robust immunity against SARS-CoV-2 and variants of concern. Zhang Ru-Yan, et al. Chemical communications (Cambridge, England) 2022 0 0. |
A Novel Prophylaxis Strategy Using Liposomal Vaccine Adjuvant CAF09b Protects against Influenza Virus Disease. Zimmermann Julie, et al. International journal of molecular sciences 2022 0 0. (3) |
Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes Lesseur, Corina et al. medRxiv February 24 2022 |
Human genetic and immunological determinants of critical COVID-19 pneumonia. Zhang Qian et al. Nature 2022 1
SARS-CoV-2 infection is benign in most individuals but, in ˜10% of cases, it triggers hypoxemic COVID-19 pneumonia, which becomes critical in ˜3% of cases. The ensuing risk of death (˜1%) doubles every five years from childhood onward and is ˜1.5 times greater in men than in women. What are the molecular and cellular determinants of critical COVID-19 pneumonia? Inborn errors of type I IFNs, including autosomal TLR3 and X-linked TLR7 deficiencies, are found in ˜1-5% of patients with critical pneumonia under 60 years old, and a lower proportion in older patients. Pre-existing autoantibodies neutralizing IFN-a, –ß, and/or –?, which are more common in men than in women, are found in ˜15-20% of patients with critical pneumonia over 70 years old, and a lower proportion in younger patients. Thus, at least 15% of cases of critical COVID-19 pneumonia can apparently be explained
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Prognostic impact of toll-like receptors gene polymorphism on outcome of COVID-19 pneumonia: A case-control study. Alseoudy Mahmoud M, et al. Clinical immunology (Orlando, Fla.) 2022 0 0. 108929 |
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males. Croci Susanna, et al. Autophagy 2021 0 0. 1-11 |
Genomic and phenotypic characterization of Multisystem Inflammatory Syndrome in Children (MIS-C): a prospective multicenter study from the Middle East Abuhammour, Walid et al. medRxiv December 02 2021 |
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