Records 1-2 (of 2 Records) |
Query Trace: SFTPD[original query] |
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Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19. Palmos Alish B et al. PLoS genetics 2022 3 (3) e1010042 |
Mapping the human genetic architecture of COVID-19: an update The COVID-19 Host Genetics Initiative, MEDRXIV, November 11, 2021
The Coronavirus Disease 2019 (COVID-19) pandemic continues to pose a major public health threat especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity we formed the COVID19 Host Genetics Initiative. Here we present GWAS meta-analysis of up to 125,584 cases and over 2.5 million controls across 60 studies from 25 countries, adding 10 new genome-wide significant loci to the 13 we previously identified1. Genes in novel loci include SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.
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