Records 1-2 (of 2 Records) |
Query Trace: RAB7A[original query] |
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Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis. Das Jayanta Kumar, et al. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2021 0 0. 104921 |
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. Daniloski Zharko et al. Cell 2020 11 (1) 92-105.e16
We performed a genome-scale CRISPR loss-of-function screen to identify host factors required for SARS-CoV-2 viral infection of human alveolar epithelial cells. Top-ranked genes cluster into distinct pathways, including the vacuolar ATPase proton pump, Retromer, and Commander complexes. Given the key role of the ACE2 receptor in the early stages of viral entry, we show that loss of RAB7A reduces viral entry by sequestering the ACE2 receptor inside cells.
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