Records 1-19 (of 19 Records) |
Query Trace: OAS3[original query] |
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The Relationship between COVID-19 Severity in Children and Immunoregulatory Gene Polymorphism. Kozak Kateryna, et al. Viruses 2023 0 0. (10) |
An integrated strategy to identify COVID-19 causal genes and characteristics represented by LRRC37A2. Zhu Zijun, et al. Journal of medical virology 2023 0 0. |
Mucosal Gene Expression in Response to SARS-CoV-2 Is Associated with Viral Load. Rajagopala Seesandra V, et al. Journal of virology 2023 0 0. e0147822 |
Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes. Gemmati Donato, et al. Frontiers in genetics 2022 0 0. 1028081 |
Association of IFNAR2 rs2236757 and OAS3 rs10735079 polymorphisms with susceptibility to COVID-19 infection and severity M Abdelhafez et al, MEDRXIV, September 27, 2022 |
Transcriptome-wide Summary Data based Mendelian Randomization analysis reveals 38 novel genes associating with Severe COVID-19. Krishnamoorthy Suhas, et al. Journal of medical virology 2022 0 0. |
Identification of key molecules in COVID-19 patients significantly correlated with clinical outcomes by analyzing transcriptomic data. Dong Zehua, et al. Frontiers in immunology 2022 0 0. 930866 |
Mucosal gene expression in response to SARS-CoV-2 is associated with early viral load. Rajagopala Seesandra V, et al. bioRxiv : the preprint server for biology 2022 0 0. |
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries. Banday A Rouf et al. Nature genetics 2022 7
In our analysis of patients of European (n?=?2,249) and African (n?=?835) ancestries with hospitalized versus nonhospitalized COVID-19, the risk of hospitalized disease was associated with a common OAS1 haplotype, which was also associated with reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance in a clinical trial with pegIFN-?1. Bioinformatic analyses and in vitro studies reveal the functional contribution of two associated OAS1 exonic variants comprising the risk haplotype. Our results provide insight into molecular mechanisms through which early treatment with interferons could accelerate SARS-CoV-2 clearance and mitigate against severe COVID-19.
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Proteomic Profiling Identifies Novel Proteins for Genetic Risk of Severe COVID-19: the Atherosclerosis Risk in Communities Study. Steffen Brian T, et al. Human molecular genetics 2022 0 0. |
Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein Fernandes, Maria Fernanda et al. bioRxiv January 12 2022 |
Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative Analyses. Baranova Ancha, et al. Frontiers in medicine 2021 0 0. 738687 |
Gene Expression Meta-Analysis Reveals Interferon-Induced Genes Associated With SARS Infection in Lungs. Park Amber, et al. Frontiers in immunology 2021 0 0. 694355 |
An integrative multiomics analysis identifies putative causal genes for COVID-19 severity. Wu Lang et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021 6
It is critical to identify putative causal targets for SARS coronavirus 2, which may guide drug repurposing options to reduce the public health burden of COVID-19. We applied complementary methods and multiphased design to pinpoint the most likely causal genes for COVID-19 severity. Through analyses of the COVID-19 HGI using complementary CMO and S-PrediXcan methods along with fine-mapping, XCR1, CCR2, SACM1L, OAS3, NSF, WNT3, NAPSA, and IFNAR2 are identified as putative causal genes for COVID-19 severity.
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Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics. Wu Mengjia, et al. Frontiers in research metrics and analytics 2021 0 0. 683212 |
Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19. Shaath Hibah, et al. Cells 2020 0 0. (11) |
Genetic mechanisms of critical illness in Covid-19 Pairo-Castineira E, et al. medRxiv, Sep 25, 2020. |
Genetic mechanisms of critical illness in COVID-19. Pairo-Castineira Erola et al. Nature 2020 12 (7848) 92-98
This is a genome-wide association study(GWAS) in 2244 critically ill Covid-19 patients from 208 UK intensive care units. We identify novel genome-wide significant associations, on chr12q24.13 in a gene cluster encoding antiviral restriction enzyme activators (OAS1, OAS2, OAS3), on chr19p13.2 near the gene encoding tyrosine kinase 2 (TYK2), on chr19p13.3 within the gene encoding dipeptidyl peptidase 9 (DPP9), and on chr21q22.1 in the interferon receptor gene IFNAR2.
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Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response. Vishnubalaji Radhakrishnan, et al. Genes 2020 7 0. (7) |
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