Records 1-30 (of 39 Records) |
Query Trace: LZTFL1[original query] |
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Next-generation sequencing of host genetics risk factors associated with COVID-19 severity and long-COVID in Colombian population. Angulo-Aguado Mariana, et al. Scientific reports 2024 0 0. (1) 8497 |
Host genetic variants associated with COVID-19 reconsidered in a Slovak cohort. Skerenova Maria, et al. Advances in medical sciences 2024 0 0. |
Canadian COVID-19 host genetics cohort replicates known severity associations. Garg Elika, et al. PLoS genetics 2024 0 0. (3) e1011192 |
ABCA3 and LZTFL1 Polymorphisms and Risk of COVID-19 in the Czech Population. Hubacek J A, et al. Physiological research 2023 0 0. (4) 539-543 |
A GWAS in the pandemic epicenter highlights the severe COVID-19 risk locus introgressed by Neanderthals. Breno Matteo, et al. iScience 2023 0 0. (10) 107629 |
Genetic variants associated with SARS-CoV-2 infection also affect lung function and asthma severity. Silva Milca de Jesus, et al. Heliyon 2023 0 0. (9) e19235 |
GWAS reveals genetic basis of a predisposition to severe COVID-19 through in silico modeling of the FYCO1 protein. Gusakova Mariya S, et al. Frontiers in medicine 2023 0 0. 1178939 |
Host genetic polymorphisms involved in long-term symptoms of COVID-19. Udomsinprasert Wanvisa, et al. Emerging microbes & infections 2023 0 0. 2239952 |
A review of the main genetic factors influencing the course of COVID-19 in Sardinia: the role of human leukocyte antigen-G. Mocci Stefano, et al. Frontiers in immunology 2023 0 0. 1138559 |
Host genetic determinants of COVID-19 susceptibility and severity: A systematic review and meta-analysis. Setegn Eshetie et al. Rev Med Virol 2023 6 e2466
The meta-analysis showed that a cluster of highly correlated 9 SNPs (R2 > 0.9) at 3p21.31 gene locus covering LZTFL1 and SLC6A20 genes was significantly associated with COVID-19 severity, with a pooled OR of 1.8 [1.5-2.0]. Meanwhile, another 3 SNPs (rs2531743-G, rs2271616-T, and rs73062389-A) within the locus was associated with COVID-19 susceptibility, with pooled estimates of 0.95 [0.93-0.96], 1.23 [1.19-1.27] and 1.15 [1.13-1.17], respectively.
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Host Genetic Factors, Comorbidities and the Risk of Severe COVID-19. Zhu Dongliang, et al. Journal of epidemiology and global health 2023 0 0. |
Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes. Gemmati Donato, et al. Frontiers in genetics 2022 0 0. 1028081 |
Genome-wide association studies of COVID-19: Connecting the dots. Ferreira Leonardo C, et al. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2022 0 0. 105379 |
COVID-19 in pediatrics: Genetic susceptibility. Glessner Joseph T, et al. Frontiers in genetics 2022 0 0. 928466 |
Genome-Wide Association Study of COVID-19 Outcomes Reveals Novel Host Genetic Risk Loci in the Serbian Population. Zecevic Marko, et al. Frontiers in genetics 2022 0 0. 911010 |
Association Between the LZTFL1 rs11385942 Polymorphism and COVID-19 Severity in Colombian Population. Angulo-Aguado Mariana, et al. Frontiers in medicine 2022 0 0. 910098 |
Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19. Rüter Jule, et al. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2022 0 0. |
The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations. Pastana Lucas Favacho, et al. Journal of personalized medicine 2022 0 0. (4) |
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease. Horowitz Julie E, et al. Nature genetics 2022 0 0. |
Proteomic Profiling Identifies Novel Proteins for Genetic Risk of Severe COVID-19: the Atherosclerosis Risk in Communities Study. Steffen Brian T, et al. Human molecular genetics 2022 0 0. |
CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1. Fink-Baldauf Iris M, et al. EBioMedicine 2022 0 0. 103806 |
Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study. de Rojas Itziar, et al. Journal of personalized medicine 2021 0 0. (12) |
Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression. Hubacek J A, et al. Physiological research 2021 0 0. (S2) S125-S134 |
Correction to: Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population. Rescenko Raimonds, et al. Virologica Sinica 2021 0 0. |
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus. Downes Damien J, et al. Nature genetics 2021 0 0. (11) 1606-1615 |
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus DJ Downes et al, Nature Genetics, November 4, 2021
ere, using a combined multiomics and machine learning approach, we identify the gain-of-function risk A allele of an SNP, rs17713054G>A, as a probable causative variant. We show with chromosome conformation capture and gene-expression analysis that the rs17713054-affected enhancer upregulates the interacting gene, leucine zipper transcription factor like 1 (LZTFL1). Selective spatial transcriptomic analysis of lung biopsies from patients with COVID-19 shows the presence of signals associated with epithelial–mesenchymal transition (EMT), a viral response pathway that is regulated by LZTFL1.
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Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population. Rescenko Raimonds, et al. Virologica Sinica 2021 0 0. |
Severe COVID-19 in Alzheimer's disease: APOE4's fault again? Xiong Nian, et al. Alzheimer's research & therapy 2021 0 0. (1) 111 |
Strong Correlation between the Case Fatality Rate of COVID-19 and the rs6598045 Single Nucleotide Polymorphism (SNP) of the Interferon-Induced Transmembrane Protein 3 (IFITM3) Gene at the Population-Level. Kim Yong-Chan, et al. Genes 2021 0 0. (1) |
Novel COVID-19 phenotype definitions reveal phenotypically distinct patterns of genetic association and protective effects Roberts, Genevieve H L et al. medRxiv January 26 2021 |
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