Records 1-9 (of 9 Records) |
Query Trace: IL15[original query] |
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An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease P Ghosh et al, Nature Comms, May 2022
We compare the two syndromes using a computational toolbox of two gene signatures that were developed in the context of SARS-CoV-2 infection, i.e., the viral pandemic (ViP) and severe-ViP signatures and a 13-transcript signature previously demonstrated to be diagnostic for KD, and validated our findings in whole blood RNA sequences, serum cytokines, and formalin fixed heart tissues. Results show that KD and MIS-C are on the same continuum of the host immune response as COVID-19. Both the pediatric syndromes converge upon an IL15/IL15RA-centric cytokine storm, suggestive of shared proximal pathways of immunopathogenesis
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Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19. Savarraj Jude, et al. Journal of neuroinflammation 2021 0 0. (1) 277 |
COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis Sinha, Saptarshi et al. bioRxiv November 30 2021 |
AI-guided discovery of the invariant host response to viral pandemics. Sahoo Debashis et al. EBioMedicine 2021 6 103390
Over 45,000 transcriptomic datasets of viral pandemics were analyzed to extract a 166-gene signature using ACE2 as a ?seed? gene; ACE2 was rationalized because it encodes the receptor that facilitates the entry of SARS-CoV-2 (the virus that causes COVID-19) into host cells. An AI-based approach was used to explore the utility of the signature. The 166-gene signature was conserved across all viral pandemics, including COVID-19, and a subset of 20-genes classified disease severity.
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Markers of brain and endothelial Injury and inflammation are acutely and sex specifically regulated in SARS-CoV-2 infection Savarraj, Jude et al. medRxiv May 27 2021 |
An AI-guided invariant signature places MIS-C with Kawasaki disease in a continuum of host immune responses. Sahoo Debashis, et al. bioRxiv : the preprint server for biology 2021 0 0. |
Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients. Yan Qihong, et al. Journal of immunology (Baltimore, Md. : 1950) 2021 0 0. |
Differentially expressed immune response genes in COVID-19 patients based on disease severity. Li Shasha, et al. Aging 2021 3 0. |
AI-guided discovery of the invariant host response to viral pandemics. Sahoo Debashis, et al. bioRxiv : the preprint server for biology 2020 9 0. |
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