Records 1-14 (of 14 Records) |
Query Trace: HLA-DQB1[original query] |
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Human leukocyte antigen variants associate with BNT162b2 mRNA vaccine response. Martina Esposito et al. Commun Med (Lond) 2024 4 (1) 63
From the abstract: "We carried out a genome-wide association study to investigate the genetic determinants of the antibody response to the Pfizer-BioNTech vaccine in an Italian cohort of 1351 subjects recruited in three centers. Linear regressions between normalized antibody levels and genotypes of more than 7 million variants was performed, using sex, age, centers, days between vaccination boost and serological test, and five principal components as covariates. We also analyzed the association between normalized antibody levels and 204 HLA alleles, with the same covariates as above. Our study confirms the involvement of the HLA locus and shows significant associations with variants in HLA-A, HLA-DQA1, and HLA-DQB1 genes. In particular, the HLA-A*03:01 allele is the most significantly associated with serum levels of anti-SARS-CoV-2 antibodies. "
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HLA typing of patients who developed subacute thyroiditis and Graves' disease after SARS-CoV-2 vaccination: a case report. Yasuda Shigemitsu, et al. BMC endocrine disorders 2023 0 0. (1) 54 |
Immunogenetic Predisposition to SARS-CoV-2 Infection. Lehmann Claudia, et al. Biology 2023 0 0. (1) |
Association of Alleles of Human Leukocyte Antigen Class II Genes and Severity of COVID-19 in Patients of the 'Red Zone' of the Endocrinology Research Center, Moscow, Russia. Troshina Ekaterina, et al. Diseases (Basel, Switzerland) 2022 0 0. (4) |
Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection. Mentzer Alexander J et al. Nature medicine 2022 10 |
Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection AJ Mentzer et al, Nature Medicine, October 13, 2022
Using data from 1,076 participants enrolled in ChAdOx1 nCov-19 vaccine efficacy trials in the United Kingdom, we find that inter-individual variation in normalised antibody responses against SARS-CoV-2 spike (S) and its receptor binding domain (RBD) at 28 days following first vaccination shows genome-wide significant association with major histocompatibility complex (MHC) class II alleles. Individuals carrying HLA-DQB1*06 alleles were less likely to experience PCR-confirmed breakthrough infection during the ancestral SARS-CoV-2 virus and subsequent Alpha-variant waves compared with non-carriers (HR 0.63, 0.42–0.93, P?=?0.02).
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Exome-Wide Association Study Reveals Host Genetic Variants Likely Associated with the Severity of COVID-19 in Patients of European Ancestry. Upadhyai Priyanka, et al. Life (Basel, Switzerland) 2022 0 0. (9) |
The association of human leucocyte antigen (HLA) alleles with COVID-19 severity: A systematic review and meta-analysis. Dobrijevic Zorana, et al. Reviews in medical virology 2022 0 0. e2378 |
Association of HLA genotypes with SARS-CoV-2 Vaccine-induced Subacute Thyroiditis. Sendur Süleyman Nahit, et al. Thyroid : official journal of the American Thyroid Association 2022 0 0. |
Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients. Gutiérrez-Bautista Juan Francisco, et al. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2021 0 0. |
Single-cell RNA sequencing identify SDCBP in ACE2-positive bronchial epithelial cells negatively correlates with COVID-19 severity. Ma Ding, et al. Journal of cellular and molecular medicine 2021 0 0. |
Bioinformatic analyses hinted at augmented T helper 17 cell differentiation and cytokine response as the central mechanism of COVID-19-associated Guillain-Barré syndrome. Li Zheng, et al. Cell proliferation 2021 0 0. (5) e13024 |
[HLA genetic polymorphisms and prognosis of patients with COVID-19]. Lorente L, et al. Medicina intensiva 2020 9 0. |
A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients. Poulton Kay, et al. International journal of immunogenetics 2020 7 0. |
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