Records 1-25 (of 25 Records) |
Query Trace: CXCR6[original query] |
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Genetic variants associated with SARS-CoV-2 infection also affect lung function and asthma severity. Silva Milca de Jesus, et al. Heliyon 2023 0 0. (9) e19235 |
Genome-wide association studies of COVID-19: Connecting the dots. Ferreira Leonardo C, et al. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2022 0 0. 105379 |
COVID-19 in pediatrics: Genetic susceptibility. Glessner Joseph T, et al. Frontiers in genetics 2022 0 0. 928466 |
The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations. Pastana Lucas Favacho, et al. Journal of personalized medicine 2022 0 0. (4) |
Integrative transcriptomic, evolutionary, and causal inference framework for region-level analysis: Application to COVID-19. Zhou Dan, et al. NPJ genomic medicine 2022 0 0. (1) 24 |
Integrative transcriptomic, evolutionary, and causal inference framework for region-level analysis: Application to COVID-19 D Zhou et al, NPJ Genomic Medicine, March 22, 2022
We developed an integrative transcriptomic, evolutionary, and causal inference framework for a deep region-level analysis, which integrates several published approaches and a new summary-statistics-based methodology. To illustrate the framework, we applied it to understanding the host genetics of COVID-19 severity. We identified putative causal genes, including SLC6A20, CXCR6, CCR9, and CCR5 in the locus on 3p21.31, quantifying their effect on mediating expression and on severe COVID-19. We confirmed that individuals who carry the introgressed archaic segment in the locus have a substantially higher risk of developing the severe disease phenotype.
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Proteomic Profiling Identifies Novel Proteins for Genetic Risk of Severe COVID-19: the Atherosclerosis Risk in Communities Study. Steffen Brian T, et al. Human molecular genetics 2022 0 0. |
Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19. Ma Yunlong, et al. Genome medicine 2022 0 0. (1) 16 |
COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types. Schmiedel Benjamin J, et al. Nature communications 2021 0 0. (1) 6760 |
Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative Analyses. Baranova Ancha, et al. Frontiers in medicine 2021 0 0. 738687 |
Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus. Kasela Silva, et al. Genome biology 2021 0 0. (1) 242 |
Bioinformatic Identification of Hub Genes and Biological Pathways for Sepsis-Associated Acute Lung Injury Zhang, Chao et al. Research Square July 13 2021 |
Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation. Dai Yulin, et al. Human genetics 2021 0 0. |
Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2. Li Fuhai, et al. BMC medical informatics and decision making 2021 0 0. (1) 15 |
The CXCR6/CXCL16 axis links inflamm-aging to disease severity in COVID-19 patients Payne, Daniel J et al. bioRxiv January 25 2021 |
Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus. Kasela Silva, et al. medRxiv : the preprint server for health sciences 2021 0 0. |
Immunogenetic Predictors of Severe COVID-19. Malkova Anna, et al. Vaccines 2021 0 0. (3) |
Genetic variability in COVID-19-related genes in the Brazilian population. Secolin Rodrigo, et al. Human genome variation 2021 0 0. (1) 15 |
Genetic variability in COVID-19-related genes in the Brazilian population. Secolin Rodrigo, et al. Human genome variation 2021 0 0. 15 |
Association of CXCR6 with COVID-19 severity: Delineating the host genetic factors in transcriptomic regulation. Dai Yulin, et al. bioRxiv : the preprint server for biology 2021 2 0. |
Why People of Bangladeshi Origin Are Most at Risk of Dying from COVID-19 in the UK, i.e., Why They Carry the Highest Level of Those Six Deleterious Neanderthal-Inherited Genes Dalton, Dave et al. SSRN August 10 2020 |
Deciphering the state of immune silence in fatal COVID-19 patients Bost, Pierre et al. medRxiv August 13 2020 |
Genetic variability in COVID-19-related genes in the Brazilian population Secolin, Rodrigo et al. bioRxiv December 06 2020 |
Repurposing drugs for COVID-19 based on transcriptional response of host
cells to SARS-CoV-2 Li, Fuhai et al. arXiv June 29 2020 |
Genomewide Association Study of Severe Covid-19 with Respiratory Failure. Ellinghaus David et al. The New England journal of medicine 2020 Jun
Genomewide Association Study of Severe Covid-19 with Respiratory Failure. Ellinghaus David, Degenhardt Frauke, Bujanda Luis, Buti Maria, Albillos Agustín, Invernizzi Pietro, Fernández Javier, Prati Daniele, Baselli Guido, Asselta Rosanna, Grimsrud Marit M, Milani Chiara, Aziz Fátima, Kässens Jan, May Sandra, Wendorff Mareike, Wienbrandt Lars, Uellendahl-Werth Florian, Zheng Tenghao, Yi Xiaoli, de Pablo Raúl, Chercoles Adolfo G, Palom Adriana, Garcia-Fernandez Alba-Estela, Rodriguez-Frias Francisco, Zanella Alberto, Bandera Alessandra, Protti Alessandro, Aghemo Alessio, Lleo Ana, Biondi Andrea, Caballero-Garralda Andrea, Gori Andrea, Tanck Anja, Carreras Nolla Anna, Latiano Anna, Fracanzani Anna Ludovica, Peschuck Anna, Julià Antonio, Pesenti Antonio, Voza Antonio, Jiménez David, Mateos Beatriz, Nafria Jimenez Beatriz, Quereda Carmen, Paccapelo Cinzia, Gassner Christoph, Angelini Claudio, Cea Cristina, Solier Aurora, Pestaña David, Muñiz-Diaz Eduardo, Sandoval Elena, Paraboschi Elvezia M, Navas Enrique, García Sánchez Félix, Ceriotti Ferruccio, Martinelli-Boneschi Filippo, Peyvandi Flora, Blasi Francesco, Téllez Luis, Blanco-Grau Albert, Hemmrich-Stanisak Georg, Grasselli Giacomo, Costantino Giorgio, Cardamone Giulia, Foti Giuseppe, Aneli Serena, Kurihara Hayato, ElAbd Hesham, My Ilaria, Galván-Femenia Iván, Martín Javier, Erdmann Jeanette, Ferrusquía-Acosta Jose, Garcia-Etxebarria Koldo, Izquierdo-Sanchez Laura, Bettini Laura R, Sumoy Lauro, Terranova Leonardo, Moreira Leticia, Santoro Luigi, Scudeller Luigia, Mesonero Francisco, Roade Luisa, Rühlemann Malte C, Schaefer Marco, Carrabba Maria, Riveiro-Barciela Mar, Figuera Basso Maria E, Valsecchi Maria G, Hernandez-Tejero María, Acosta-Herrera Marialbert, D'Angiò Mariella, Baldini Marina, Cazzaniga Marina, Schulzky Martin, Cecconi Maurizio, Wittig Michael, Ciccarelli Michele, Rodríguez-Gandía Miguel, Bocciolone Monica, Miozzo Monica, Montano Nicola, Braun Nicole, Sacchi Nicoletta, Martínez Nilda, Özer Onur, Palmieri Orazio, Faverio Paola, Preatoni Paoletta, Bonfanti Paolo, Omodei Paolo, Tentorio Paolo, Castro Pedro, Rodrigues Pedro M, Blandino Ortiz Aaron, de Cid Rafael, Ferrer Ricard, Gualtierotti Roberta, Nieto Rosa, Goerg Siegfried, Badalamenti Salvatore, Marsal Sara, Matullo Giuseppe, Pelusi Serena, Juzenas Simonas, Aliberti Stefano, Monzani Valter, Moreno Victor, Wesse Tanja, Lenz Tobias L, Pumarola Tomas, Rimoldi Valeria, Bosari Silvano, Albrecht Wolfgang, Peter Wolfgang, Romero-Gómez Manuel, D'Amato Mauro, Duga Stefano, Banales Jesus M, Hov Johannes R, Folseraas Trine, Valenti Luca, Franke Andre, Karlsen Tom H, .The New England journal of medicine 2020 Jun Ellinghaus David et al. The New England journal of medicine 2020 Jun The New England journal of medicine There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19.We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the final analysis. In total, we analyzed 8,582,968 single-nucleotide polymorphisms and conducted a meta-analysis of the two case-control panels.We detected cross-replicating associations with rs11385942 at locus 3p21.31 and with rs657152 at locus 9q34.2, which were significant at the genomewide level (P<5×10 -8 ) in the meta-analysis of the two case-control panels (odds ratio, 1.77; 95% confidence interval [CI], 1.48 to 2.11; P?=?1.15×10 -10 ; and odds ratio, 1.32; 95% CI, 1.20 to 1.47; P?=?4.95×10 -8 , respectively). At locus 3p21.31, the association signal spanned the genes SLC6A20 , LZTFL1 , CCR9 , FYCO1 , CXCR6 and XCR1 . The association signal at locus 9q34.2 coincided with the ABO blood group locus; in this cohort, a blood-group-specific analysis showed a higher risk in blood group A than in other blood groups (odds ratio, 1.45; 95% CI, 1.20 to 1.75; P?=?1.48×10 -4 ) and a protective effect in blood group O as compared with other blood groups (odds ratio, 0.65; 95% CI, 0.53 to 0.79; P?=?1.06×10 -5 ).We identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and confirmed a potential involvement of the ABO blood-group system. (Funded by Stein Erik Hagen and others.).Copyright © 2020 Massachusetts Medical Society. Ellinghaus David, Degenhardt Frauke, Bujanda Luis, Buti Maria, Albillos Agustín, Invernizzi Pietro, Fernández Javier, Prati Daniele, Baselli Guido, Asselta Rosanna, Grimsrud Marit M, Milani Chiara, Aziz Fátima, Kässens Jan, May Sandra, Wendorff Mareike, Wienbrandt Lars, Uellendahl-Werth Florian, Zheng Tenghao, Yi Xiaoli, de Pablo Raúl, Chercoles Adolfo G, Palom Adriana, Garcia-Fernandez Alba-Estela, Rodriguez-Frias Francisco, Zanella Alberto, Bandera Alessandra, Protti Alessandro, Aghemo Alessio, Lleo Ana, Biondi Andrea, Caballero-Garralda Andrea, Gori Andrea, Tanck Anja, Carreras Nolla Anna, Latiano Anna, Fracanzani Anna Ludovica, Peschuck Anna, Julià Antonio, Pesenti Antonio, Voza Antonio, Jiménez David, Mateos Beatriz, Nafria Jimenez Beatriz, Quereda Carmen, Paccapelo Cinzia, Gassner Christoph, Angelini Claudio, Cea Cristina, Solier Aurora, Pestaña David, Muñiz-Diaz Eduardo, Sandoval Elena, Paraboschi Elvezia M, Navas Enrique, García Sánchez Félix, Ceriotti Ferruccio, Martinelli-Boneschi Filippo, Peyvandi Flora, Blasi Francesco, Téllez Luis, Blanco-Grau Albert, Hemmrich-Stanisak Georg, Grasselli Giacomo, Costantino Giorgio, Cardamone Giulia, Foti Giuseppe, Aneli Serena, Kurihara Hayato, ElAbd Hesham, My Ilaria, Galván-Femenia Iván, Martín Javier, Erdmann Jeanette, Ferrusquía-Acosta Jose, Garcia-Etxebarria Koldo, Izquierdo-Sanchez Laura, Bettini Laura R, Sumoy Lauro, Terranova Leonardo, Moreira Leticia, Santoro Luigi, Scudeller Luigia, Mesonero Francisco, Roade Luisa, Rühlemann Malte C, Schaefer Marco, Carrabba Maria, Riveiro-Barciela Mar, Figuera Basso Maria E, Valsecchi Maria G, Hernandez-Tejero María, Acosta-Herrera Marialbert, D'Angiò Mariella, Baldini Marina, Cazzaniga Marina, Schulzky Martin, Cecconi Maurizio, Wittig Michael, Ciccarelli Michele, Rodríguez-Gandía Miguel, Bocciolone Monica, Miozzo Monica, Montano Nicola, Braun Nicole, Sacchi Nicoletta, Martínez Nilda, Özer Onur, Palmieri Orazio, Faverio Paola, Preatoni Paoletta, Bonfanti Paolo, Omodei Paolo, Tentorio Paolo, Castro Pedro, Rodrigues Pedro M, Blandino Ortiz Aaron, de Cid Rafael, Ferrer Ricard, Gualtierotti Roberta, Nieto Rosa, Goerg Siegfried, Badalamenti Salvatore, Marsal Sara, Matullo Giuseppe, Pelusi Serena, Juzenas Simonas, Aliberti Stefano, Monzani Valter, Moreno Victor, Wesse Tanja, Lenz Tobias L, Pumarola Tomas, Rimoldi Valeria, Bosari Silvano, Albrecht Wolfgang, Peter Wolfgang, Romero-Gómez Manuel, D'Amato Mauro, Duga Stefano, Banales Jesus M, Hov Johannes R, Folseraas Trine, Valenti Luca, Franke Andre, Karlsen Tom H, .The New England journal of medicine 2020 Jun
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