Records 1-18 (of 18 Records) |
Query Trace: CD209[original query] |
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Whole genome sequencing reveals host factors underlying critical Covid-19. Kousathanas Athanasios, et al. Nature 2022 0 0. |
Whole genome sequencing reveals host factors underlying critical Covid-19 A Kousathanas et al, Nature, March 7, 2022
Here, we use whole genome sequencing in 7,491 critically-ill cases compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical Covid-19. We identify 16 new independent associations, including variants within genes involved in interferon signalling (IL10RB, PLSCR1), leucocyte differentiation (BCL11A), and blood type antigen secretor status (FUT2). Using transcriptome-wide association and colocalisation to infer the effect of gene expression on disease severity, we find evidence implicating multiple genes, including reduced expression of a membrane flippase (ATP11A), and increased mucin expression (MUC1), in critical disease. Mendelian randomisation provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5, CD209) and coagulation factor F8, all of which are potentially druggable targets.
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BSG/CD147 and ACE2 receptors facilitate SARS-CoV-2 infection of human iPS cell-derived kidney podocytes. Kalejaiye Titilola D, et al. bioRxiv : the preprint server for biology 2021 0 0. |
A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance. Anisul Mohd, et al. eLife 2021 0 0. |
Single-cell RNA Sequencing of SARS-CoV-2 Cell Entry Factors in the Preconceptional Human Endometrium. Vilella F, et al. Human reproduction (Oxford, England) 2021 0 0. |
An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility. Wang Liuyang, et al. Genome medicine 2021 0 0. (1) 83 |
Further insights into the molecular complexity of the human sinus node - The role of 'novel' transcription factors and microRNAs. Aminu Abimbola J, et al. Progress in biophysics and molecular biology 2021 0 0. |
Genetic polymorphisms as multi-biomarkers in severe acute respiratory syndrome (SARS) by coronavirus infection: A systematic review of candidate gene association studies. Dos Santos Ana Caroline Melo, et al. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2021 0 0. 104846 |
An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility. Wang Liuyang, et al. medRxiv : the preprint server for health sciences 2020 12 0. |
Understand Variability of COVID-19 Through Population and Tissue Variations in Expression of SARS-CoV-2 Host Genes Chen, Liang et al. SSRN July 20 2020 |
Understand variability of COVID-19 through population and tissue variations in expression of SARS-CoV-2 host genes. Chen Liang, et al. Informatics in medicine unlocked 2020 0 0. 100443 |
Infectivity and Progression of COVID-19 Based on Selected Host Candidate Gene Variants. Iyer Gayatri R, et al. Frontiers in genetics 2020 0 0. 861 |
Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis. Smatti Maria K, et al. Frontiers in genetics 2020 0 0. 578523 |
Smoking and SARS-CoV-2 Impair Dendritic Cells and Regulate DC-SIGN Expression in Tissues Cai, Guoshuai et al. medRxiv December 30 2020 |
C-type Lectin CD209L/L-SIGN and CD209/DC-SIGN: Cell Adhesion Molecules Turned to Pathogen Recognition Receptors. Rahimi Nader, et al. Biology 2020 0 0. (1) |
Mining a GWAS of Severe Covid-19. Katz Daniel H et al. The New England journal of medicine 2020 12 (26) 2589
The COVID-19 genetic risk variant rs657152-A at the ABO locus is strongly associated with increased levels of the CD209 antigen. This dendritic cell-surface protein has been found to facilitate infection by SARS-CoV-2 and other viruses.
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Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis. Di Maria Emilio, et al. Human genomics 2020 9 0. (1) 30 |
Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19. Katz Daniel H, et al. medRxiv : the preprint server for health sciences 2020 6 0. |
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