Records 1-30 (of 42 Records) |
Query Trace: CCR5[original query] |
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Adverse effect of VEGFR-2 (rs1870377) polymorphism on the clinical course of COVID-19 in females and males in an age-dependent manner. Sayin Kocakap Derya Beyza, et al. Microbes and infection 2023 0 0. 105188 |
In silico analysis of dietary polyphenols and their gut microbial metabolites suggest inhibition of SARS-CoV-2 infection, replication, and host inflammatory mediators. Mezhibovsky Esther, et al. Journal of biomolecular structure & dynamics 2023 0 0. 1-19 |
Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals. Jagoda Evelyn, et al. eLife 2023 0 0. |
Prognostic markers for the clinical course in the blood of patients with SARS-CoV-2 infection. Fischer Johannes C, et al. European journal of medical research 2022 0 0. (1) 255 |
COVID-19 in pediatrics: Genetic susceptibility. Glessner Joseph T, et al. Frontiers in genetics 2022 0 0. 928466 |
Allelic Variations in the Human Genes TMPRSS2 and CCR5, and the Resistance to Viral Infection by SARS-CoV-2. Vitello Girolamo Aurelio, et al. International journal of molecular sciences 2022 0 0. (16) |
Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity. Gupta Kajal, et al. Gene 2022 0 0. 146790 |
Prognostic markers for the clinical course in the blood of patients with SARS-CoV-2 infection JC Fischer et al, Research Square, July 19,2022
igh-resolution HLA typing was performed in 536 non-hospitalized patients infected with SARS-CoV2. For HLA-Class I we obtained results from 519 patients, and for HLA-Class-II from 531. Patients who became ill between March 2020 and August 2021 were tested for the 22 most common HLA class I (HLA-A, -B, -C) or HLA class II (HLA –DRB1/3/4, -DQA1, -DQB1) haplotypes in this collective. The identified HLA haplotypes were associated to disease severity. We also analyzed the influence of CCR5 and the ABO blood groups on the disease duration. Results: The influence of the HLA haplotypes on disease severity was stronger than the influence of age, sex, AB0 blood group, or wave of infection with different mutants of the virus. The presence of mutated CCR5 resulted in a longer recovery period.
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Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysis. Dieter Cristine, et al. PloS one 2022 0 0. (7) e0270627 |
Factors associated with weak positive SARS-CoV-2 diagnosis by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR). Rawat Priyank, et al. Pathology 2022 0 0. |
Effect of Chemokine Gene Variants on Covid-19 Disease Severity. Dogan Seydanur, et al. Immunological investigations 2022 0 0. 1-10 |
Insights into potential mechanisms of asthma patients with COVID-19: A study based on the gene expression profiling of bronchoalveolar lavage fluid. Jiang Yong, et al. Computers in biology and medicine 2022 0 0. 105601 |
The Association of COVID-19 Severity and Susceptibility and Genetic Risk Factors: A Systematic Review of the literature. Ishak Angela, et al. Gene 2022 0 0. 146674 |
Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages. Stikker Bernard S, et al. Genome biology 2022 0 0. (1) 96 |
Integrative transcriptomic, evolutionary, and causal inference framework for region-level analysis: Application to COVID-19. Zhou Dan, et al. NPJ genomic medicine 2022 0 0. (1) 24 |
Integrative transcriptomic, evolutionary, and causal inference framework for region-level analysis: Application to COVID-19 D Zhou et al, NPJ Genomic Medicine, March 22, 2022
We developed an integrative transcriptomic, evolutionary, and causal inference framework for a deep region-level analysis, which integrates several published approaches and a new summary-statistics-based methodology. To illustrate the framework, we applied it to understanding the host genetics of COVID-19 severity. We identified putative causal genes, including SLC6A20, CXCR6, CCR9, and CCR5 in the locus on 3p21.31, quantifying their effect on mediating expression and on severe COVID-19. We confirmed that individuals who carry the introgressed archaic segment in the locus have a substantially higher risk of developing the severe disease phenotype.
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The major genetic risk factor for severe COVID-19 is associated with protection against HIV. Zeberg Hugo, et al. Proceedings of the National Academy of Sciences of the United States of America 2022 0 0. (9) |
Potential Genes Associated with COVID-19 and Comorbidity. Feng Shanshan, et al. International journal of medical sciences 2022 0 0. (2) 402-415 |
Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression. Hubacek J A, et al. Physiological research 2021 0 0. (S2) S125-S134 |
Could the CCR5-Delta32 mutation be protective in SARS-CoV-2 infection? Starcevic Cizmarevic N, et al. Physiological research 2021 0 0. (S2) S249-S252 |
Candidate genes of SARS-CoV-2 gender susceptibility. Russo Cristina, et al. Scientific reports 2021 0 0. (1) 21968 |
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection. Andreakos Evangelos, et al. Nature immunology 2021 0 0. |
Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative Analyses. Baranova Ancha, et al. Frontiers in medicine 2021 0 0. 738687 |
CCL5/CCR5 axis in human diseases and related treatments. Zeng Zhen, et al. Genes & diseases 2021 0 0. |
Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19. Fischer Johannes C, et al. European journal of medical research 2021 0 0. (1) 107 |
Bioinformatic analyses suggest augmented interleukin-17 signaling as the mechanism of COVID-19-associated herpes zoster. Yu Xin, et al. Environmental science and pollution research international 2021 0 0. |
Genetic mechanisms of COVID-19 and its association with smoking and alcohol consumption. Rao Shuquan, et al. Briefings in bioinformatics 2021 0 0. |
Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection Patterson, Bruce K et al. bioRxiv July 09 2021 |
Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning. Patterson Bruce K, et al. Frontiers in immunology 2021 0 0. 700782 |
Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals Jagoda, Evelyn et al. bioRxiv June 14 2021 |
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