In 155,958 SARS-CoV-2 genomes, we found that models that included viral genomic variants outperformed other models (AUC=0.91 as compared with 0.68 for age and gender alone; p<0.001). Among individual variants, we found 17 single nucleotide variants in SARS-CoV-2 have more than two-fold greater odds of being associated with higher severity and 67 variants associated with =0.5 times the odds of severity.

After two stevedores in Qingdao, China, developed COVID-19, packages of imported frozen cod in a shipment they had handled were found to be contaminated with closely related SARS-CoV-2 of apparent European origin. The authors postulate that transport at freezing temperatures maintained virus viability during transport.

This study mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that enhance or inhibit viral infection. For a subset of interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes.

We developed a blood-based generalizable host-gene-expression-based classifier for the severity of viral infections and validated it in multiple viral infection settings including COVID-19. We selected 6 host mRNAs and trained a logistic regression classifier with a training AUROC of 0.90 for predicting 30-day mortality in viral illnesses. In validation cohorts the locked 6-mRNA classifier had an AUROC of 0.91.

In 155,958 SARS-CoV-2 genomes, we found that models that included viral genomic variants outperformed other models (AUC=0.91 as compared with 0.68 for age and gender alone; p<0.001). Among individual variants, we found 17 single nucleotide variants in SARS-CoV-2 have more than two-fold greater odds of being associated with higher severity and 67 variants associated with =0.5 times the odds of severity.

After two stevedores in Qingdao, China, developed COVID-19, packages of imported frozen cod in a shipment they had handled were found to be contaminated with closely related SARS-CoV-2 of apparent European origin. The authors postulate that transport at freezing temperatures maintained virus viability during transport.

This study mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that enhance or inhibit viral infection. For a subset of interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes.

We developed a blood-based generalizable host-gene-expression-based classifier for the severity of viral infections and validated it in multiple viral infection settings including COVID-19. We selected 6 host mRNAs and trained a logistic regression classifier with a training AUROC of 0.90 for predicting 30-day mortality in viral illnesses. In validation cohorts the locked 6-mRNA classifier had an AUROC of 0.91.

In 155,958 SARS-CoV-2 genomes, we found that models that included viral genomic variants outperformed other models (AUC=0.91 as compared with 0.68 for age and gender alone; p<0.001). Among individual variants, we found 17 single nucleotide variants in SARS-CoV-2 have more than two-fold greater odds of being associated with higher severity and 67 variants associated with =0.5 times the odds of severity.

After two stevedores in Qingdao, China, developed COVID-19, packages of imported frozen cod in a shipment they had handled were found to be contaminated with closely related SARS-CoV-2 of apparent European origin. The authors postulate that transport at freezing temperatures maintained virus viability during transport.

This study mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that enhance or inhibit viral infection. For a subset of interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes.

We developed a blood-based generalizable host-gene-expression-based classifier for the severity of viral infections and validated it in multiple viral infection settings including COVID-19. We selected 6 host mRNAs and trained a logistic regression classifier with a training AUROC of 0.90 for predicting 30-day mortality in viral illnesses. In validation cohorts the locked 6-mRNA classifier had an AUROC of 0.91.