We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. We identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and confirmed a potential involvement of the ABO blood-group system.

In this retrospective study of 7246 patients hospitalized with COVID-19, we identified 12 patients with DS. Hospitalized individuals with DS are on average ten years younger than patients without DS. Patients with DS have more severe disease than controls, particularly an increased incidence of sepsis and mechanical ventilation.

We propose an algorithm for pooling subsamples based on the geometry of a hypercube that, at low prevalence, accurately identifies infected individuals in a small number of tests and rounds of testing. We discuss the optimal group size and explain why largely parallel searches are preferred. We report proof of concept experiments in which a positive subsample was detected even when diluted 100-fold with negative subsamples.

We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. We identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and confirmed a potential involvement of the ABO blood-group system.

In this retrospective study of 7246 patients hospitalized with COVID-19, we identified 12 patients with DS. Hospitalized individuals with DS are on average ten years younger than patients without DS. Patients with DS have more severe disease than controls, particularly an increased incidence of sepsis and mechanical ventilation.

We propose an algorithm for pooling subsamples based on the geometry of a hypercube that, at low prevalence, accurately identifies infected individuals in a small number of tests and rounds of testing. We discuss the optimal group size and explain why largely parallel searches are preferred. We report proof of concept experiments in which a positive subsample was detected even when diluted 100-fold with negative subsamples.

We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. We identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and confirmed a potential involvement of the ABO blood-group system.

In this retrospective study of 7246 patients hospitalized with COVID-19, we identified 12 patients with DS. Hospitalized individuals with DS are on average ten years younger than patients without DS. Patients with DS have more severe disease than controls, particularly an increased incidence of sepsis and mechanical ventilation.

We propose an algorithm for pooling subsamples based on the geometry of a hypercube that, at low prevalence, accurately identifies infected individuals in a small number of tests and rounds of testing. We discuss the optimal group size and explain why largely parallel searches are preferred. We report proof of concept experiments in which a positive subsample was detected even when diluted 100-fold with negative subsamples.