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Published on 08/06/2020

COVID-19 Genomics and Precision Public Health Weekly Update Content

Pathogen and Human Genomics Studies

  • Swabs Collected by Patients or Health Care Workers for SARS-CoV-2 Testing.
    Tu Yuan-Po et al. The New England journal of medicine 2020 07 (5) 494-496
    Our study shows the clinical usefulness of tongue, nasal, or mid-turbinate samples collected by patients as compared with nasopharyngeal samples collected by health care workers for the diagnosis of Covid-19.
  • Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection
    V Ramlall et al, Nature Medicine, August 3, 2020
    In a genetic association study of severe disease, we identified putative complement and coagulation-associated loci including missense, eQTL and sQTL variants of complement and coagulation regulators. In addition to providing evidence that complement function modulates outcome, the data point to putative transcriptional genetic markers of susceptibility.
  • Genomic heterogeneity and clinical characterization of SARS-CoV-2 in Oregon
    AK Dowdell et al, MEDRXIV, August 4, 2o020
    We report viral sequences from 188 patients across the hospitals and associated clinics in Oregon dating back to the early days of the outbreak. We show a rapid emergence and dominance of Spike D614G-positive variants. We also highlight significant diversity in sequences indicative that these genomes could be utilized for outbreak tracing.

Non-Genomics Precision Health Studies

  • Swabs Collected by Patients or Health Care Workers for SARS-CoV-2 Testing.
    Tu Yuan-Po et al. The New England journal of medicine 2020 07 (5) 494-496
    Our study shows the clinical usefulness of tongue, nasal, or mid-turbinate samples collected by patients as compared with nasopharyngeal samples collected by health care workers for the diagnosis of Covid-19.
  • Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection
    V Ramlall et al, Nature Medicine, August 3, 2020
    In a genetic association study of severe disease, we identified putative complement and coagulation-associated loci including missense, eQTL and sQTL variants of complement and coagulation regulators. In addition to providing evidence that complement function modulates outcome, the data point to putative transcriptional genetic markers of susceptibility.
  • Genomic heterogeneity and clinical characterization of SARS-CoV-2 in Oregon
    AK Dowdell et al, MEDRXIV, August 4, 2o020
    We report viral sequences from 188 patients across the hospitals and associated clinics in Oregon dating back to the early days of the outbreak. We show a rapid emergence and dominance of Spike D614G-positive variants. We also highlight significant diversity in sequences indicative that these genomes could be utilized for outbreak tracing.

News, Reviews and Commentaries

  • Swabs Collected by Patients or Health Care Workers for SARS-CoV-2 Testing.
    Tu Yuan-Po et al. The New England journal of medicine 2020 07 (5) 494-496
    Our study shows the clinical usefulness of tongue, nasal, or mid-turbinate samples collected by patients as compared with nasopharyngeal samples collected by health care workers for the diagnosis of Covid-19.
  • Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection
    V Ramlall et al, Nature Medicine, August 3, 2020
    In a genetic association study of severe disease, we identified putative complement and coagulation-associated loci including missense, eQTL and sQTL variants of complement and coagulation regulators. In addition to providing evidence that complement function modulates outcome, the data point to putative transcriptional genetic markers of susceptibility.
  • Genomic heterogeneity and clinical characterization of SARS-CoV-2 in Oregon
    AK Dowdell et al, MEDRXIV, August 4, 2o020
    We report viral sequences from 188 patients across the hospitals and associated clinics in Oregon dating back to the early days of the outbreak. We show a rapid emergence and dominance of Spike D614G-positive variants. We also highlight significant diversity in sequences indicative that these genomes could be utilized for outbreak tracing.
Disclaimer: Articles listed in COVID-19 Genomics and Precision Public Health Weekly Update are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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