Last data update: Jun 24, 2024. (Total: 47078 publications since 2009)
Records 1-3 (of 3 Records) |
Query Trace: Zivkovich Z [original query] |
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Cause-specific mortality among a cohort of U.S. flight attendants
Pinkerton LE , Waters MA , Hein MJ , Zivkovich Z , Schubauer-Berigan MK , Grajewski B . Am J Ind Med 2011 55 (1) 25-36 BACKGROUND: We evaluated mortality among 11,311 former U.S. flight attendants. The primary a priori outcomes of interest were breast cancer and melanoma. METHODS: Vital status was ascertained through 2007, and life table analyses was conducted. Cumulative exposure to cosmic radiation and circadian rhythm disruption were estimated from work history data and historical published flight schedules. RESULTS: All-cause mortality was less than expected among women but was elevated among men, primarily due to elevated HIV-related disease mortality. Mortality from breast cancer among women and melanoma was neither significantly elevated nor related to metrics of exposure. Mortality was elevated for non-Hodgkin's lymphoma among men; for alcoholism, drowning, and intentional self-harm among women; and for railway, water, and air transportation accidents. CONCLUSIONS: We found no evidence of increased breast cancer or melanoma mortality. Limitations include reliance on mortality data and limited power resulting from few melanoma deaths and relatively short employment durations. Am. J. Ind. Med. (c) 2011 Wiley Periodicals, Inc. |
Airline pilot cosmic radiation and circadian disruption exposure assessment from logbooks and company records
Grajewski B , Waters MA , Yong LC , Tseng CY , Zivkovich Z , Cassinelli RT 2nd . Ann Occup Hyg 2011 55 (5) 465-75 OBJECTIVES: US commercial airline pilots, like all flight crew, are at increased risk for specific cancers, but the relation of these outcomes to specific air cabin exposures is unclear. Flight time or block (airborne plus taxi) time often substitutes for assessment of exposure to cosmic radiation. Our objectives were to develop methods to estimate exposures to cosmic radiation and circadian disruption for a study of chromosome aberrations in pilots and to describe workplace exposures for these pilots. METHODS: Exposures were estimated for cosmic ionizing radiation and circadian disruption between August 1963 and March 2003 for 83 male pilots from a major US airline. Estimates were based on 523,387 individual flight segments in company records and pilot logbooks as well as summary records of hours flown from other sources. Exposure was estimated by calculation or imputation for all but 0.02% of the individual flight segments' block time. Exposures were estimated from questionnaire data for a comparison group of 51 male university faculty. RESULTS: Pilots flew a median of 7126 flight segments and 14 959 block hours for 27.8 years. In the final study year, a hypothetical pilot incurred an estimated median effective dose of 1.92 mSv (absorbed dose, 0.85 mGy) from cosmic radiation and crossed 362 time zones. This study pilot was possibly exposed to a moderate or large solar particle event a median of 6 times or once every 3.7 years of work. Work at the study airline and military flying were the two highest sources of pilot exposure for all metrics. An index of work during the standard sleep interval (SSI travel) also suggested potential chronic sleep disturbance in some pilots. For study airline flights, median segment radiation doses, time zones crossed, and SSI travel increased markedly from the 1990s to 2003 (P(trend) < 0.0001). Dose metrics were moderately correlated with records-based duration metrics (Spearman's r = 0.61-0.69). CONCLUSIONS: The methods developed provided an exposure profile of this group of US airline pilots, many of whom have been exposed to increasing cosmic radiation and circadian disruption from the 1990s through 2003. This assessment is likely to decrease exposure misclassification in health studies. |
Development of historical exposure estimates of cosmic radiation and circadian rhythm disruption for cohort studies of Pan Am flight attendants
Waters MA , Grajewski B , Pinkerton LE , Hein MJ , Zivkovich Z . Am J Ind Med 2009 52 (10) 751-61 BACKGROUND: The National Institute for Occupational Safety and Health is conducting cohort studies of flight crew employed by the former Pan American World Airways company (Pan Am) as part of an effort to examine flight crew workplace exposures and health effects. Flight crew are exposed to elevated levels of cosmic radiation and to disruption of circadian rhythm when flying across multiple time zones. Methods exist to calculate cosmic radiation effective doses on individual flights; however, only work histories which provided an employee's domicile (home base) history rather than a record of every flight flown were available. METHODS/RESULTS: We developed a method for estimating individual cumulative domicile-based cosmic radiation effective doses and two metrics for circadian rhythm disruption for each flight attendant: cumulative times zones crossed and cumulative travel time during the standard sleep interval. CONCLUSIONS: The domicile-exposure matrix developed was used to calculate exposure estimates for a cohort mortality study of former Pan Am flight attendants. Am. J. Ind. Med. 2009. Published 2009 Wiley-Liss, Inc. |
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