Last data update: Sep 16, 2024. (Total: 47680 publications since 2009)
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Editorial: Glial cells: Managers of neuro-immunity
Barcia C , Guillemin GJ , Curtin JF , Zirger JM . Front Cell Neurosci 2016 10 60 After many decades of study in the field of Neuroscience that were mostly centered on the neuron there is a mounting interest in the study of the function of the glial cells in many aspects and functions of the central nervous system. The involvement of glial cells in neuroimmunity is one of the critical pieces within this puzzle, and one that entails great complexity. An increasing number of publications shows that resident astroglia and microglia are the real managers of immune responses, orchestrating chemokine and cytokine release, blood cell infiltration, and promotion of angiogenesis, etc. Moreover, each disease and neuroinflammatory scenario seems to have its own distinct biochemical characteristics and glial phenotype. Classical definitions of resting and activated microglial cells or pro-inflammatory and anti-inflammatory phenotypes are recognized today as oversimplified models of glial cell functions and have since been surpassed by more defined and precise characterizations. The present Frontiers Research Topic (FRT) is a great example of this, since the study of different scenarios reflects diverse modes of glial activation and distinct complexities. | We present here a selection of articles, both original research and reviews, solving clinical, and basic aspects of the biology of glial cells in neuro-inflammatory and neuro-immune scenarios. |
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