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COVID-10 GPH

Last data update: Apr 28, 2025. (Total: 49156 publications since 2009)
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Query Trace: Waters MS[original query]
Conjugal Transfer, Whole Genome Sequencing, and Plasmid Analysis of Four mcr-1 -bearing Isolates from U.S. Patients.
Zhu W , Lawsin A , Lindsey RL , Batra D , Knipe K , Yoo BB , Perry KA , Rowe LA , Lonsway D , Waters MS , Rasheed JK , Halpin AL .
Antimicrob Agents Chemother 2019 63 (4) type type

Four Enterobacteriaceae clinical isolates bearing mcr-1 gene-harboring plasmids were characterized. All isolates demonstrated the ability to transfer colistin resistance to E. coli; plasmids were stable in conjugants after multiple passages on non-selective media. mcr-1 was located on an IncX4 (n=3) or IncN (n=1) plasmid. The IncN plasmid harbored 13 additional antimicrobial resistance genes. Results indicate the mcr-1-bearing plasmids in this study are highly transferable in vitro and stable in the recipients.
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