Last data update: May 28, 2024. (Total: 46864 publications since 2009)
Records 1-3 (of 3 Records) |
Query Trace: Sutcliff A [original query] |
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Spatial, environmental, and individual associations with Anopheles albimanus salivary antigen IgG in Haitian children
Jaramillo-Underwood A , Herman C , Impoinvil D , Sutcliff A , Knipes A , Worrell CM , Fox LM , Desir L , Fayette C , Javel A , Monestime F , Mace KE , Chang MA , Lemoine JF , Won K , Udhayakumar V , Rogier E . Front Cell Infect Microbiol 2022 12 1033917 IgG serology can be utilized to estimate exposure to Anopheline malaria vectors and the Plasmodium species they transmit. A multiplex bead-based assay simultaneously detected IgG to Anopheles albimanus salivary gland extract (SGE) and four Plasmodium falciparum antigens (CSP, LSA-1, PfAMA1, and PfMSP1) in 11,541 children enrolled at 350 schools across Haiti in 2016. Logistic regression estimated odds of an above-median anti-SGE IgG response adjusting for individual- and environmental-level covariates. Spatial analysis detected statistically significant clusters of schools with students having high anti-SGE IgG levels, and spatial interpolation estimated anti-SGE IgG levels in unsampled locations. Boys had 11% (95% CI: 0.81, 0.98) lower odds of high anti-SGE IgG compared to girls, and children seropositive for PfMSP1 had 53% (95% CI: 1.17, 2.00) higher odds compared to PfMSP1 seronegatives. Compared to the lowest elevation, quartiles 2-4 of higher elevation were associated with successively lower odds (0.81, 0.43, and 0.34, respectively) of high anti-SGE IgG. Seven significant clusters of schools were detected in Haiti, while spatially interpolated results provided a comprehensive picture of anti-SGE IgG levels in the study area. Exposure to malaria vectors by IgG serology with SGE is a proxy to approximate vector biting in children and identify risk factors for vector exposure. |
Factors associated with human IgG antibody response to Anopheles albimanus salivary gland extract: Artibonite Department, Haiti, 2017
Jaramillo-Underwood A , Impoinvil D , Sutcliff A , Hamre KES , Joseph V , Hoogen LVD , Frantz Lemoine J , Ashton RA , Chang MA , Existe A , Boncy J , Drakeley C , Stresman G , Druetz T , Eisele T , Rogier E . J Infect Dis 2022 226 (8) 1461-1469 Serological data can provide estimates of human exposure to both malaria vector and parasite based on antibody responses. A multiplex bead-based assay was developed to simultaneously detect IgG to Anopheles albimanus salivary gland extract (SGE) and 23 Plasmodium falciparum antigens among 4,185 participants enrolled in Artibonite department, Haiti in 2017. Logistic regression adjusted for participant- and site-level covariates and found children under 5 years and 6-15 years old had 3.7- and 5.4-fold increase in odds, respectively, of high anti-SGE IgG compared to participants >15 years. Seropositivity to P. falciparum CSP, Rh2_2030, and SEA-1 antigens was significantly associated with high IgG response against SGE, and participant enrollment at elevations under 200m was associated with higher anti-SGE IgG levels. The ability to approximate population exposure to malaria vectors through SGE serology data is very dependent by age categories, and SGE antigens can be easily integrated into a multiplex serological assay. |
COVID-19 Outbreaks at Two Construction Sites - New York City, October-November 2020.
Bushman D , Sekaran J , Jeffery N , Rath C , Ackelsberg J , Weiss D , Wu W , Van Oss K , Johnston K , Huang J , Khatun U , Sheikh T , Sutcliff J , Tsoi B . Clin Infect Dis 2021 73 S81-S83 During October 23-November 16, 2020, the New York City Department of Health and Mental Hygiene investigated COVID-19 outbreaks at two construction sites. Challenges in adhering to the New York State Department of Health "Interim COVID-19 Guidance for Construction" were reported. To minimize outbreaks, jurisdictions should increase tailored outreach to the construction industry emphasizing infection prevention. |
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