Last data update: Jun 24, 2024. (Total: 47078 publications since 2009)
Records 1-3 (of 3 Records) |
Query Trace: Scinicariello Franco [original query] |
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Study shows noisy restaurants pose health risks
Eichwald John , Murphy William J , Scinicariello Franco . Hear J 2022 75 (1) 8,10,11,12-8,10,11,12 Loud restaurant noise can be a barrier to communication and enjoyment of a dining experience and might increase the risk for adverse health effects among patrons and employees. In addition to adversely affecting the subjective quality of the dining experience, environments that require a person to raise their voice to be understood an arm's length distance suggest an ambient sound level sufficient to create a risk for noise-induce hearing loss. |
Characterization and allelic polymorphisms of rhesus macaque (Macaca mulatta) IgG Fc receptor genes.
Nguyen DC , Scinicariello F , Attanasio R . Immunogenetics 2011 63 (6) 351-62 ![]() Macaque models are invaluable for AIDS research. Indeed, initial development of HIV-1 vaccines relies heavily on simian immunodeficiency virus-infected rhesus macaques. Neutralizing antibodies, a major component of anti-HIV protective responses, ultimately interact with Fc receptors on phagocytic and natural killer cells to eliminate the pathogen. Despite the major role that Fc receptors play in protective responses, there is very limited information available on these molecules in rhesus macaques. Therefore, in this study, rhesus macaque CD32 (FcgammaRII) and CD64 (FcgammaRI) homologues were genetically characterized. In addition, presence of CD16 (FcgammaRIII), CD32, and CD64 allelic polymorphisms were determined in a group of nine animals. Results from this study show that the predicted structures of macaque CD32 and CD64 are highly similar to their human counterparts. Macaque and human CD32 and CD64 extracellular domains are 88-90% and 94-95% homologous, respectively. Although all cysteines are conserved between the two species, macaque CD32 exhibits two additional N-linked glycosylation sites, whereas CD64 lacks three of them when compared to humans. Five CD32, three CD64, and three CD16 distinct allelic sequences were indentified in the nine animals examined, indicating a relatively high level of polymorphism in macaque Fcgamma receptors. Together, these results validate rhesus macaques as models for vaccine development and antibody responses, while at the same time, underscoring the need to take into account the high degree of genetic heterogeneity present in this species when designing experimental protocols. |
The impact of CYP2E1 genetic variability on risk assessment of VOC mixtures.
Pohl HR , Scinicariello F . Regul Toxicol Pharmacol 2011 59 (3) 364-74 ![]() Humans are simultaneously exposed to multiple chemicals in the environment. Many of the chemicals use the same enzymes in their metabolic pathways. Competitive inhibition may occur as one of the possible interactions between the xenobiotics in human body. For example, many volatile organic compounds (VOCs) are metabolized using P450 enzymes, specifically CYP2E1. Inheritable gene alterations may result in changes of function of the enzymes in different human subpopulations. Variations in quantity and/or quality of particular isoenzymes may cause differences in the metabolism of VOCs. These variations may cause higher sensitivity in certain populations. Using examples of three different mixtures, this review paper outlines the variances in CYP 2E1 isoenzymes, effect of exposure to such mixtures on sensitive populations, and approaches to mixtures risk assessment. |
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