Last data update: Jun 11, 2024. (Total: 46992 publications since 2009)
Records 1-3 (of 3 Records) |
Query Trace: Reiss E [original query] |
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Developing a reference system for the IFCC standardization of HbA
Paleari R , Caruso D , Kaiser P , Arsene CG , Schaeffer-Reiss C , Van Dorsselaer A , Bisse E , Ospina M , De Jesus VR , Wild B , Mosca A . Clin Chim Acta 2016 467 21-26 The importance of hemoglobin A2 (HbA2) as an indicator of the presence of beta-thalassemia was established many years ago. However, clinical application of recommended HbA2 cut off values is often hampered due to poor equivalence of HbA2 results among methods and laboratories. Thus, the IFCC Standardization program for HbA2 was initiated in 2004 with the goal of achieving a complete reference system for this measurand. HbA2 standardization efforts are still in progress, including the development of a higher-order HbA2 reference measurement procedure and the preparation of a certified reference material in collaboration with the IRMM. Here, we review the past, present and future of HbA2 standardization and describe the current status of HbA2 testing. |
Passive surveillance for azole-resistant Aspergillus fumigatus, United States, 2011-2013
Pham CD , Reiss E , Hagen F , Meis JF , Lockhart SR . Emerg Infect Dis 2014 20 (9) 1498-503 Emergence of Aspergillus fumigatus strains containing mutations that lead to azole resistance has become a serious public health threat in many countries. Nucleotide polymorphisms leading to amino acid substitutions in the lanosterol demethylase gene (cyp51A) are associated with reduced susceptibility to azole drugs. The most widely recognized mutation is a lysine to histidine substitution at aa 98 (L98H) and a duplication of the untranscribed promoter region, together known as TR34/L98H. This mechanism of resistance has been reported in Europe, Asia, and the Middle East, and is associated with resistance to all azole drugs and subsequent treatment failures. To determine whether isolates with this mutation are spreading into the United States, we conducted a passive surveillance-based study of 1,026 clinical isolates of A. fumigatus from 22 US states during 2011-2013. No isolates harboring the TR34/L98H mutation were detected, and MICs of itraconazole were generally low. |
Genotyping of Candida parapsilosis from three neonatal intensive care units (NICUs) using a panel of five multilocus microsatellite markers: broad genetic diversity and a cluster of related strains in one NICU.
Reiss E , Lasker BA , Lott TJ , Bendel CM , Kaufman DA , Hazen KC , Wade KC , McGowan KL , Lockhart SR . Infect Genet Evol 2012 12 (8) 1654-60 ![]() Candida parapsilosis (CP) (n=40) isolated from an unselected patient population in the neonatal intensive care units (NICUs) of 3 U.S. hospitals were collected over periods of 3.5-9 years. Two previously published microsatellite markers and three additional trinucleotide markers were used to produce multiplex genotypes, which revealed broad strain diversity among the NICU isolates with a combined index of discrimination (D)=0.997. A cluster of 8 related CP strains from 4 infants in a single NICU was observed. An extended collection of 24 CP isolates from the general population of that hospital showed that the cluster of NICU isolates was related to 3 isolates from general hospital patients. This microsatellite marker set is suitable to investigate clusters of colonizing and infecting strains of CP. |
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