Last data update: Sep 23, 2024. (Total: 47723 publications since 2009)
Records 1-11 (of 11 Records) |
Query Trace: Ragin-Wilson A [original query] |
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Federal Research Action Plan on Recycled Tire Crumb Used on Playing Fields: Tire Crumb Rubber Characterization and Exposure Characterization Study Overview
Benson K , Irvin-Barnwell E , Ragin-Wilson A , Breysse P . J Environ Health 2019 82 (2) 28-30 As part of our continued effort to highlight innovative approaches to improve the health and environment of communities, the Journal is pleased to publish a bimonthly column from the Agency for Toxic Substances and Disease Registry (ATSDR) at the Centers for Disease Control and Prevention (CDC). ATSDR serves the public by using the best science, taking responsive public health actions, and providing trusted health information to prevent harmful exposures and diseases related to toxic substances. The purpose of this column is to inform readers of ATSDR's activities and initiatives to better understand the relationship between exposure to hazardous substances in the environment, its impact on human health, and how to protect public health. The conclusions of this column are those of the author(s) and do not necessarily represent the official position of ATSDR or CDC. Kelsey Benson is an environmental epidemiologist at ATSDR. Elizabeth Irvin-Barnwell currently serves as the acting chief of the Environmental Epidemiology Branch at ATSDR. Angela Ragin-Wilson currently serves as the acting deputy director of the Division of Toxicology and Human Health Sciences at ATSDR. Pat Breysse is the director of CDC's National Center for Environmental Health/ATSDR. |
Blood cadmium, lead, manganese, mercury, and selenium levels in American Indian populations: The Strong Heart Study
Li Z , Lewin M , Ruiz P , Nigra AE , Henderson N , Jarrett JM , Ward C , Zhu J , Umans JG , O'Leary M , Zhang Y , Ragin-Wilson A , Navas-Acien A . Environ Res 2022 215 114101 BACKGROUND: Many American Indian (AI) communities are in areas affected by environmental contamination, such as toxic metals. However, studies assessing exposures in AI communities are limited. We measured blood metals in AI communities to assess historical exposure and identify participant characteristics associated with these levels in the Strong Heart Study (SHS) cohort. METHOD: Archived blood specimens collected from 2014 participants (all participants were 50 years of age and older) in Arizona, Oklahoma, and North and South Dakota during SHS Phase-III (1998-1999) were analyzed for cadmium, lead, manganese, mercury, and selenium using inductively coupled plasma triple quadrupole mass spectrometry. We conducted descriptive analyses for the entire cohort and stratified by selected subgroups, including selected demographics, health behaviors, income, waist circumference, and body mass index. Bivariate associations were conducted to examine associations between blood metal levels and selected socio-demographic and behavioral covariates. Finally, multivariate regression models were used to assess the best model fit that predicted blood metal levels. FINDINGS: All elements were detected in 100% of study participants, with the exception of mercury (detected in 73% of participants). The SHS population had higher levels of blood cadmium and manganese than the general U.S. population 50 years and older. The blood mercury median of the SHS population was at about 30% of the U.S. reference population, potentially due to low fish consumption. Participants in North and South Dakota had the highest blood cadmium, lead, manganese, and selenium, and the lowest total mercury levels, even after adjusting for covariates. In addition, each of the blood metals was associated with selected demographic, behavioral, income, and/or weight-related factors in multivariate models. These findings will help guide the tribes to develop education, outreach, and strategies to reduce harmful exposures and increase beneficial nutrient intake in these AI communities. |
Biomonitoring of toxic metals, organochlorine pesticides, and polybrominated biphenyl 153 in Michigan urban anglers
Wattigney WA , Irvin-Barnwell E , Li Z , Ragin-Wilson A . Environ Res 2021 203 111851 The 32-mile Detroit River and surrounding tributaries have been designated as a Great Lakes Area of Concern due to pollution from decades of municipal and industrial discharges, sewer overflows and urban development. The Agency for Toxic Substances and Disease Registry and the Michigan Department of Health and Human Services conducted a biomonitoring study to assess exposures to persistent toxic substances in Detroit urban shoreline anglers who may be at high exposure risk due to consumption of locally caught fish. Using a modified venue-based sampling approach, 287 adult shoreline anglers along the Detroit River were recruited and participated in the program. Study participants provided blood and urine specimens and completed a questionnaire interview. In this report, we examine percentile estimates for blood lead, blood manganese, urine arsenic, urine mercury, urine cadmium, organochlorine pesticides in serum (mirex, hexachlorobenzene, chlordane), and serum polybrominated biphenyl 153 (PBB 153) concentrations among study participants. Multiple linear regression was used to identify predictors of contaminant concentrations. The Detroit urban anglers' blood lead concentrations were 2 times higher than the general adult U.S. population (median (95% CI): 2.9 μg/dL (1.8-2.3) vs. 0.94 μg/dL (0.90-0.98)). PBB 153 levels were 1.8 times higher than the general adult U.S. population at the 95th percentile (95th percentile, 95% CI: 62.7 ng/g of lipid, 53.2-75.2 vs. 34.6 ng/g of lipid, 12.8-66.8). Percentile estimates of the other study pollutants were similar to background levels found in the general U.S. population. Eating more locally caught fish was not associated with increased body burdens for any of the contaminants examined in this report. Higher blood lead was associated with increased age, male sex, current smoking, residing in a home built before 1960, an annual income less than $25,000, and a work history of lead paint removal. Evidence of PBB exposure in our study cohort likely reflects the continued effect of a widespread contamination of livestock feed in 1973 among Michigan's lower peninsula population. These study results help determine if the pollutants examined warrant further consideration in subsequent population-based biomonitoring of frequent consumers of fish from the Detroit River and surrounding waterways. The biomonitoring data from this study also served to inform public health officials regarding the potential need for environmental public health actions to reduce harmful exposures. |
The biomonitoring of Great Lakes populations-iii program: The Milwaukee Angler Project
Li Z , Serio T , Meiman J , He X , Ragin-Wilson A . J Environ Health 2021 83 (6) 40-43 The Great Lakes ecosystem has been contaminated by industrial, agricultural, and other | human activities. Both Canada and the U.S. | have been mitigating this historical contamination across the Great Lakes. Particularly, | the U.S. established the Great Lakes Restoration Initiative (GLRI) in 2009 to accelerate | and coordinate efforts to protect and restore | the Great Lakes region. GLRI provided funds | to the Agency for Toxic Substances and | Disease Registry (ATSDR) to establish the | Biomonitoring of Great Lakes Populations | (BGLP) Programs in 2010. In these programs, ATSDR and state health departments | conducted a series of cross-sectional studies | to assess body burden levels of legacy and | emerging contaminants among populations | with potential high exposure in the Great | Lakes region. The programs also aimed to | use biomonitoring data to inform and guide | public health actions to protect Great Lakes | populations from harmful exposure (Wattigney et al., 2017; Wattigney, Irvin-Barnwell, | Li, Davis, et al., 2019). |
Characterization of trace elements exposure in pregnant women in the United States, NHANES 1999-2016
Watson CV , Lewin M , Ragin-Wilson A , Jones R , Jarrett JM , Wallon K , Ward C , Hilliard N , Irvin-Barnwell E . Environ Res 2020 183 109208 OBJECTIVE: The objective of the current study is to report on urine, blood and serum metal concentrations to characterize exposures to trace elements and micronutrient levels in both pregnant women and women of child-bearing age in the U.S. National Health and Nutrition Examination Survey (NHANES) years 1999-2016. METHODS: Urine and blood samples taken from NHANES participants were analyzed for thirteen urine metals, three blood metals, three serum metals, speciated mercury in blood and speciated arsenic in urine. Adjusted and unadjusted least squares geometric means and 95% confidence intervals were calculated for all participants among women aged 15-44 years. Changes in exposure levels over time were also examined. Serum cotinine levels were used to adjust for smoke exposure, as smoking is a source of metal exposure. RESULTS: Detection rates for four urine metals from the ATSDR Substance Priority List: arsenic, lead, mercury and cadmium were ~83-99% for both pregnant and non-pregnant women of child bearing age. A majority of metal concentrations were higher in pregnant women compared to non-pregnant women. Pregnant women had higher mean urine total arsenic, urine mercury, and urine lead; however, blood lead and mercury were higher in non-pregnant women. Blood lead, cadmium, mercury, as well as urine antimony, cadmium and lead in women of childbearing age decreased over time, while urine cobalt increased over time. CONCLUSIONS: Pregnant women in the US have been exposed to several trace metals, with observed concentrations for some trace elements decreasing since 1999. |
Associations between select blood VOCs and hematological measures in NHANES 2005-2010
Vaughan Watson C , Naik S , Lewin M , Ragin-Wilson A , Irvin-Barnwell E . J Expo Sci Environ Epidemiol 2020 31 (2) 366-376 Exposure to VOCs is linked to health effects ranging from asthma to cancer and to negative impacts on the hematopoietic system. We examined the association between select blood VOC concentrations and hematological measures in a representative sample of the U.S. population from NHANES cycles spanning the years 2005 to 2010. We used Cox regression to assess the association between complete blood count with five-part differential (CBC) parameters and seven select blood VOCs, while addressing low detection rates among VOCs. Tobacco smoke exposure was classified using serum cotinine levels. The not-smoke-exposed group had lower VOC levels for most analytes compared with the smoke-exposed. Correlations between benzene, toluene, ethylbenzene, and xylenes (BTEX) were moderate to strong. Statistical associations were found between benzene, toluene, ethylbenzene, xylene, and styrene (BTEXS) and hematocrit, hemoglobin, and white blood cell count among the smoke-exposed. Among the not-smoke-exposed, there was an association between BTEX and platelet count. We considered benzene most likely to be associated with higher levels of CBC concentrations. Our findings suggest VOC levels currently found in the general U.S. population are associated with changes in hematological measures, and smoking could be a contributor. |
Biomonitoring of mercury and persistent organic pollutants in Michigan urban anglers and association with fish consumption
Wattigney WA , Irvin-Barnwell E , Li Z , Ragin-Wilson A . Int J Hyg Environ Health 2019 222 (6) 936-944 The 32-mile Detroit River and surrounding tributaries have been designated as a Great Lakes Area of Concern due to pollution from decades of municipal and industrial discharges, sewer overflows and urban development. Key pollutants in fish samples from the Detroit River include mercury, polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), dioxins and furans. A biomonitoring study was conducted to assess exposures to these persistent toxic substances in Detroit urban shoreline anglers who may be at high exposure risk due to consumption of locally caught fish. Using a modified venue-based sampling approach, 287 adult shoreline anglers along the Detroit River were recruited and participated in the program. Study participants provided blood and urine specimens and completed a questionnaire following informed consent. We examined percentile estimates for total blood mercury, PCBs, DDE, and dioxin-like total toxic equivalency (TEQ) concentrations among study participants. Multiple linear regression was used to identify important predictors of contaminant concentrations. Participants consumed a median of 64 Detroit River caught fish meals in the past year. The Detroit urban anglers' median total blood mercury concentrations was 3.2 times higher than that for the general adult U.S. population. PCB concentrations among the Detroit anglers aged 18-39 years were higher than the U.S. population of the same race/ethnicity. Elevated levels of DDE and total TEQ concentrations were not observed in the cohort. Eating more locally caught fish was associated with higher total blood mercury and serum PCB concentrations. The biomonitoring data served to inform public health officials and help guide environmental public health actions to reduce harmful exposures. |
Biomonitoring programs in Michigan, Minnesota and New York to assess human exposure to Great Lakes contaminants
Wattigney WA , Irvin-Barnwell E , Li Z , Davis SI , Manente S , Maqsood J , Scher D , Messing R , Schuldt N , Hwang SA , Aldous KM , Lewis-Michl EL , Ragin-Wilson A . Int J Hyg Environ Health 2018 222 (1) 125-135 Over the past century, industrialization and urban practices have resulted in the contamination of the Great Lakes ecosystem-the world's largest surface freshwater system-that provides drinking water and recreation to more than 40 million residents. In 2010, the Great Lakes Restoration Initiative was launched to accelerate efforts to protect and restore the Great Lakes and surrounding areas. Funded by GLRI, the Agency for Toxic Substances and Disease Registry initiated the Biomonitoring of Great Lakes Populations (BGLP) program. The objective of the program is to assess human exposure to legacy and emerging contaminants in the Great Lakes by measuring the body burden of contaminants in potentially susceptible populations. The BGLP program consists of a series of cross-sectional studies carried out collaboratively with states that are funded through ATSDR. The first BGLP Program (BGLP-I) began in 2010 and was completed in September 2015 through cooperative agreements with state health departments in Michigan, Minnesota, and New York. The three state programs targeted susceptible adult populations living in designated areas of contamination. Contaminants measured in all populations include mercury, lead, mirex, hexachlorobenzene, dichlorodiphenyltrichloroethane, and selected polychlorinated biphenyl congeners. In addition, some chemicals of emerging concern, such as per- and polyfluoroalkyl substances, were measured in several populations. The biomonitoring results helped guide public health actions to mitigate chemical exposures in these vulnerable Great Lakes populations. We provide an overview of the BGLP-I program's study populations, designs, and general methods. This overview provides a lead-in for subsequent manuscripts that present human biomonitoring data for legacy and emerging contaminants in culturally diverse susceptible populations-i.e., shoreline anglers, sport anglers, American Indians, and Burmese immigrants-residing in seven areas of concern. |
The biomonitoring of Great Lakes Populations Program
Wattigney WA , Li Z , Ragin-Wilson A . J Environ Health 2017 79 (8) 42-44 Over the past century, careless practices have resulted in contamination of the Great Lakes ecosystem, the world’s largest fresh surface water system. Over 30 million people live on the U.S. side of the Great Lakes basin, which spans eight states. Local, state, and federal agencies in the U.S. and Canada have passed environmental laws aimed at reducing the levels of pollution. Legacy pollutants banned or phased out of commerce decades ago in sediment, ongoing industrial and municipal discharges, agricultural runoff, leachate from disposal sites, contaminated groundwater, and atmospheric deposition, however, continue to pose environmental and public health concerns. The U.S. and Canada have identified 43 environmentally degraded surface water systems called areas of concern (AOCs) (U.S. Environmental Protection Agency, 2017). |
Regional variation in human exposure to persistent organic pollutants in the United States, NHANES
Wattigney WA , Irvin-Barnwell E , Pavuk M , Ragin-Wilson A . J Environ Public Health 2015 2015 571839 We examined serum levels of persistent organic pollutants (POPs) among geographical regions of the United States as defined by the US Census Bureau. National Health and Nutrition Examination Survey (NHANES) data for adults aged 20 years and older are presented for selected survey periods between 1999 and 2010. From NHANES 1999 through 2004, dichlorodiphenyldichloroethylene (DDE) concentration levels were consistently higher among people living in the West than in the Midwest, Northeast, or South. In 2003-2010, perfluorinated compound concentrations tended to be highest in the South. The sum of 35 polychlorinated biphenyls (PCBs) congeners was significantly higher in the Northeast [GM: 189; 95% CI: 173-204 ng/g lipid] than the remaining regions. The regional differences in higher body burdens of exposure to particular POPs could be attributed to a variety of activities, including region-specific patterns of land use and industrial and agricultural chemical applications, as well as different levels of regulatory activity. |
The Navajo Birth Cohort Study
Hunter CM , Lewis J , Peter D , Begay MG , Ragin-Wilson A . J Environ Health 2015 78 (2) 42-45 The Navajo Nation encompasses more | than 24,000 square miles across three | states—New Mexico, Utah, and Arizona— | and is the largest Alaska Native/American | Indian Reservation in the U.S. From 1944 | to 1986, hundreds of uranium mining and | milling operations extracted an estimated | 400 million tons of uranium ore from Navajo | lands. These mining and processing operations have left a legacy of potential exposures | to uranium waste from abandoned mines/ | mills, drinking water and soil contamination, | and homes and structures built with mining waste (U.S. Environmental Protection | Agency [U.S. EPA], 2014). |
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