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COVID-10 GPH

Last data update: Apr 18, 2025. (Total: 49119 publications since 2009)
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Query Trace: Pareso S[original query]
Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells
Tkach AV , Yanamala N , Stanley S , Shurin MR , Shurin GV , Kisin ER , Murray AR , Pareso S , Khaliullin T , Kotchey GP , Castranova V , Mathur S , Fadeel B , Star A , Kagan VE , Shvedova AA .
Small 2013 9 1686-1690

Graphene oxide (GO) and C60- or C60-TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells. While C60-fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C60-fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines. (Copyright 2013 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.)
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