Last data update: Sep 23, 2024. (Total: 47723 publications since 2009)
Records 1-6 (of 6 Records) |
Query Trace: Palomeque FS [original query] |
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Strategies to strengthen COVID-19 vaccine uptake and improve vaccine equity in U.S. Territories and Freely Associated States during the first six months of vaccine rollout
Tippins A , Acevedo JC , Palomeque FS , Coy KC , Chadd P , Stowell D , Ademokun O , Apaisam C , Basilius M , Brostrom R , Collazo IOG , Encarnacion J , Gerena IC , Hancock T , Hunte-Ceasar T , Judicpa P , Leon-Guerrero M , Martinez M , Masunu Y , Pangelinan H , Parian E , Pedro D . Vaccine 2024 The eight U.S. territories and freely associated states (TFAS) have historically faced unique social and structural barriers in the implementation of vaccination programs due to geographic remoteness, a high prevalence of socioeconomic disparities, increasing prevalence of natural disasters, limited vaccine providers and clinics, difficulties with procurement and shipping, and difficulty tracking highly mobile populations. In the months leading up to emergency authorizations for the use of COVID-19 vaccines, the TFAS developed tailored vaccination strategies to ensure that key at-risk populations received timely vaccination, and successfully implemented these strategies during the first six months of the vaccine rollout. Subject matter experts supporting the Centers for Disease Control and Prevention's COVID-19 Response recognized the unique historical, geographic, social, and cultural dynamics for residents in the TFAS and worked with partners to prevent, detect, and respond to the pandemic in these jurisdictions. As a result of innovative partnerships and vaccine distribution strategies, vaccine equity was improved in the TFAS during the COVID-19 vaccine rollout. |
New York State, New York City, New Jersey, Puerto Rico, and the US Virgin Islands' Health Department experiences promoting health equity during the initial COVID-19 Omicron variant period, 2021-2022
Cox H , Gebru Y , Horter L , Palomeque FS , Myers K , Stowell D , Easterling T , de Noguera NS , Medina-Forrester A , Bravo J , Pérez S , Chaparro J , Ekpo LP , Cranford H , Santibañez S , Valencia D . Health Secur 2023 21 S25-S34 In this case study, we aim to understand how health departments in 5 US jurisdictions addressed health inequities and implemented strategies to reach populations disproportionately affected by COVID-19 during the initial Omicron variant period. We used qualitative methods to examine health department experiences during the initial Omicron surge, from November 2021 to April 2022, assessing successful interventions, barriers, and lessons learned from efforts to promote health equity. Our findings indicate that government leadership supported prioritizing health equity from the beginning of the pandemic, seeing it as a need and vital part of the response framework. All jurisdictions acknowledged the historical trauma and distrust of the government. Health departments found that collaborating and communicating with trusted community leaders helped mitigate public distrust. Having partnerships, resources, and infrastructure in place before the pandemic facilitated the establishment of equity-focused COVID-19 response activities. Finally, misinformation about COVID-19 was a challenge for all jurisdictions. Addressing the needs of diverse populations involves community-informed decisionmaking, diversity of thought, and delivery measures that are tailored to the community. It is imperative to expand efforts to reduce and eliminate health inequities to ensure that individuals and communities recover equitably from the effects of COVID-19. |
Efficacy of inactivated trivalent influenza vaccine in rural India: a 3-year cluster-randomised controlled trial
Sullender WM , Fowler KB , Gupta V , Krishnan A , Ram Purakayastha D , Srungaram Vln R , Lafond KE , Saha S , Palomeque FS , Gargiullo P , Jain S , Lal R , Widdowson MA , Broor S . Lancet Glob Health 2019 7 (7) e940-e950 BACKGROUND: Paediatric vaccination against influenza can result in indirect protection, by reducing transmission to their unvaccinated contacts. We investigated whether influenza vaccination of children would protect them and their household members in a resource-limited setting. METHODS: We did a cluster-randomised, blinded, controlled study in three villages in India. Clusters were defined as households (ie, dwellings that shared a courtyard), and children aged 6 months to 10 years were eligible for vaccination as and when they became age-eligible throughout the study. Households were randomly assigned (1:1) by a computer-based system to intramuscular trivalent inactivated influenza vaccine (IIV3) or a control of inactivated poliovirus vaccine (IPV) in the beginning of the study; vaccination occurred once a year for 3 years. The primary efficacy outcome was laboratory-confirmed influenza in a vaccinated child with febrile acute respiratory illness, analysed in the modified intention-to-treat population (ie, children who received at least one dose of vaccine, were under surveillance, and had not an influenza infection within 15 days of last vaccine dose). The secondary outcome for indirect effectiveness (surveillance study) was febrile acute respiratory illness in an unvaccinated household member of a vaccine study participant. Data from each year (year 1: November, 2009, to October, 2010; year 2: October, 2010, to October, 2011; and year 3: October, 2011, to May, 2012) were analysed separately. Safety was analysed among all participants who were vaccinated with at least one dose of the vaccine. This trial is registered with ClinicalTrials.gov, number NCT00934245. FINDINGS: Between Nov 1, 2009, to May 1, 2012, we enrolled 3208 households, of which 1959 had vaccine-eligible children. 1010 households were assigned to IIV3 and 949 households were assigned to IPV. In 3 years, we vaccinated 4345 children (2132 with IIV3 and 2213 with IPV) from 1868 households (968 with IIV3 and 900 with IPV) with 10 813 unvaccinated household contacts. In year 1, influenza virus was detected in 151 (10%) of 1572 IIV3 recipients and 206 (13%) of 1633 of IPV recipients (total IIV3 vaccine efficacy 25.6% [95% CI 6.8-40.6]; p=0.010). In year 2, 105 (6%) of 1705 IIV3 recipients and 182 (10%) of 1814 IPV recipients had influenza (vaccine efficacy 41.0% [24.1-54.1]; p<0.0001). In year 3, 20 (1%) of 1670 IIV3 recipients and 81 (5%) of 1786 IPV recipients had influenza (vaccine efficacy 74.2% [57.8-84.3]; p<0.0001). In year 1, total vaccine efficacy against influenza A(H1N1)pdm09 was 14.5% (-20.4 to 39.3). In year 2, total vaccine efficacy against influenza A(H3N2) was 64.5% (48.5-75.5). Total vaccine efficacy against influenza B was 32.5% (11.3-48.6) in year 1, 4.9% (-38.9 to 34.9) in year 2, and 76.5% (59.4-86.4) in year 3. Indirect vaccine effectiveness was statistically significant only in year 3 (38.1% [7.4-58.6], p=0.0197) when influenza was detected in 39 (1%) of 4323 IIV3-allocated and 60 (1%) of 4121 IPV-allocated household unvaccinated individuals. In the IIV3 group, 225 (12%) of 1632 children in year 1, 375 (22%) of 1718 in year 2, and 209 (12%) of 1673 in year 3 had an adverse reaction (compared with 216 [13%] of 1730, 380 [21%] of 1825, and 235 [13%] of 1796, respectively, in the IPV group). The most common reactions in both groups were fever and tenderness at site. No vaccine-related deaths occurred in either group. INTERPRETATION: IIV3 provided variable direct and indirect protection against influenza infection. Indirect protection was significant during the year of highest direct protection and should be considered when quantifying the effect of vaccination programmes. FUNDING: US Centers for Disease Control and Prevention. |
On palms, bugs, and Chagas disease in the Americas
Abad-Franch F , Lima MM , Sarquis O , Gurgel-Goncalves R , Sanchez-Martin M , Calzada J , Saldana A , Monteiro FA , Palomeque FS , Santos WS , Angulo VM , Esteban L , Dias FB , Diotaiuti L , Bar ME , Gottdenker NL . Acta Trop 2015 151 126-41 Palms are ubiquitous across Neotropical landscapes, from pristine forests or savannahs to large cities. Although palms provide useful ecosystem services, they also offer suitable habitat for triatomines and for Trypanosoma cruzi mammalian hosts. Wild triatomines often invade houses by flying from nearby palms, potentially leading to new cases of human Chagas disease. Understanding and predicting triatomine-palm associations and palm infestation probabilities is important for enhancing Chagas disease prevention in areas where palm-associated vectors transmit T. cruzi. We present a comprehensive overview of palm infestation by triatomines in the Americas, combining a thorough reanalysis of our published and unpublished records with an in-depth review of the literature. We use site-occupancy modeling (SOM) to examine infestation in 3590 palms sampled with non-destructive methods, and standard statistics to describe and compare infestation in 2940 palms sampled by felling-and-dissection. Thirty-eight palm species (18 genera) have been reported to be infested by approximately 39 triatomine species (10 genera) from the USA to Argentina. Overall infestation varied from 49.1-55.3% (SOM) to 62.6-66.1% (dissection), with important heterogeneities among sub-regions and particularly among palm species. Large palms with complex crowns (e.g., Attalea butyracea, Acrocomia aculeata) and some medium-crowned palms (e.g., Copernicia, Butia) are often infested; in slender, small-crowned palms (e.g., Euterpe) triatomines associate with vertebrate nests. Palm infestation tends to be higher in rural settings, but urban palms can also be infested. Most Rhodnius species are probably true palm specialists, whereas Psammolestes, Eratyrus, Cavernicola, Panstrongylus, Triatoma, Alberprosenia, and some Bolboderini seem to use palms opportunistically. Palms provide extensive habitat for enzootic T. cruzi cycles and a critical link between wild cycles and transmission to humans. Unless effective means to reduce contact between people and palm-living triatomines are devised, palms will contribute to maintaining long-term and widespread, albeit possibly low-intensity, transmission of human Chagas disease. Graphical Abstract summary Palms are widely distributed throughout the Americas, as this 1853 map by Alfred Russel Wallace shows. This distribution almost perfectly matches the distribution of endemic human Chagas disease. Palm-living triatomine bugs make up the bridge between palms and disease. The bugs share palm crown habitats with Trypanosoma cruzi hosts. Flying from palms, infected vectors invade houses and can transmit the parasite to humans. Understanding the ecological links between palms and the parasite's vectors and hosts will be crucial for the long-term prevention of human Chagas disease. |
Determination of predominance of influenza virus strains in the Americas
Azziz-Baumgartner E , Garten RJ , Palekar R , Cerpa M , Mirza S , Ropero AM , Palomeque FS , Moen A , Bresee J , Shaw M , Widdowson MA . Emerg Infect Dis 2015 21 (7) 1209-12 During 2001-2014, predominant influenza A(H1N1) and A(H3N2) strains in South America predominated in all or most subsequent influenza seasons in Central and North America. Predominant A(H1N1) and A(H3N2) strains in North America predominated in most subsequent seasons in Central and South America. Sharing data between these subregions may improve influenza season preparedness. |
Introducing seasonal influenza vaccine in low-income countries: an adverse events following immunization survey in the Lao People's Democratic Republic
Phengxay M , Mirza SA , Reyburn R , Xeuatvongsa A , Winter C , Lewis H , Olsen SJ , Tsuyuoka R , Khanthamaly V , Palomeque FS , Bresee JS , Moen AC , Corwin AL . Influenza Other Respir Viruses 2015 9 (2) 94-8 OBJECTIVE: In 2012, Lao PDR introduced seasonal influenza vaccine in pregnant women, persons aged ≥50 years, persons with chronic diseases, and healthcare personnel. We assessed adverse events following immunization (AEFI). METHODS: We used a multistage randomized cluster sample design to interview vaccine recipients. FINDINGS: Between April and May 2012, 355 902 were vaccinated. Of 2089 persons interviewed, 261 (12.5%) reported one or more AEFI. The most commonly reported AEFIs were local reactions. No hospitalizations or deaths were reported; 16% sought medical care. Acceptance and awareness of vaccination were high. CONCLUSIONS: Following the introduction of seasonal influenza vaccine in Lao PDR, self-reported adverse events were mild. |
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