Last data update: Sep 16, 2024. (Total: 47680 publications since 2009)
Records 1-9 (of 9 Records) |
Query Trace: Nzussouo NT [original query] |
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Incidence of medically attended influenza among residents of Shai-Osudoku and Ningo-Prampram Districts, Ghana, May 2013 - April 2015
Ntiri MP , Duque J , McMorrow ML , Frimpong JA , Parbie P , Badji E , Nzussouo NT , Benson EM , Adjabeng M , Dueger E , Widdowson MA , Dawood FS , Koram K , Ampofo W . BMC Infect Dis 2016 16 (1) 757 BACKGROUND: Influenza vaccination is recommended by the World Health Organization for high risk groups, yet few data exist on influenza disease burden in West Africa. METHODS: We estimated medically attended influenza-associated illness rates among residents of Shai-Osudoku and Ningo Pram-Pram Districts (SONPD), Ghana. From May 2013 to April 2015, we conducted prospective surveillance for severe acute respiratory illness (SARI) and influenza-like illness (ILI) in 17 health facilities. In 2015, we conducted a retrospective assessment at an additional 18 health facilities to capture all SONPD SARI and ILI patients during the study period. We applied positivity rates to those not tested to estimate total influenza cases. RESULTS: Of 612 SARI patients tested, 58 (9%) were positive for influenza. The estimated incidence of influenza-associated SARI was 30 per 100,000 persons (95% CI: 13-84). Children aged 0 to 4 years had the highest influenza-associated SARI incidence (135 per 100,000 persons, 95% CI: 120-152) and adults aged 25 to 44 years had the lowest (3 per 100,000 persons, 95% CI: 1-7) (p < 0.01). Of 2,322 ILI patients tested, 407 (18%) were positive for influenza. The estimated incidence of influenza-associated ILI was 844 per 100,000 persons (95% CI: 501-1,099). The highest incidence of influenza-associated ILI was also among children aged 0 to 4 years (3,448 per 100,000 persons, 95% CI: 3,727 - 3,898). The predominant circulating subtype during May to December 2013 and January to April 2015 was influenza A(H3N2) virus, and during 2014 influenza B virus was the predominant circulating type. CONCLUSIONS: Influenza accounted for 9% and 18% of medically attended SARI and ILI, respectively. Rates were substantive among young children and suggest the potential value of exploring the benefits of influenza vaccination in Ghana, particularly in this age group. |
Effects of climatological parameters in modeling and forecasting seasonal influenza transmission in Abidjan, Cote d'Ivoire
N'Gattia A K , Coulibaly D , Nzussouo NT , Kadjo HA , Cherif D , Traore Y , Kouakou BK , Kouassi PD , Ekra KD , Dagnan NS , Williams T , Tiembre I . BMC Public Health 2016 16 (1) 972 BACKGROUND: In temperate regions, influenza epidemics occur in the winter and correlate with certain climatological parameters. In African tropical regions, the effects of climatological parameters on influenza epidemics are not well defined. This study aims to identify and model the effects of climatological parameters on seasonal influenza activity in Abidjan, Cote d'Ivoire. METHODS: We studied the effects of weekly rainfall, humidity, and temperature on laboratory-confirmed influenza cases in Abidjan from 2007 to 2010. We used the Box-Jenkins method with the autoregressive integrated moving average (ARIMA) process to create models using data from 2007-2010 and to assess the predictive value of best model on data from 2011 to 2012. RESULTS: The weekly number of influenza cases showed significant cross-correlation with certain prior weeks for both rainfall, and relative humidity. The best fitting multivariate model (ARIMAX (2,0,0) _RF) included the number of influenza cases during 1-week and 2-weeks prior, and the rainfall during the current week and 5-weeks prior. The performance of this model showed an increase of >3 % for Akaike Information Criterion (AIC) and 2.5 % for Bayesian Information Criterion (BIC) compared to the reference univariate ARIMA (2,0,0). The prediction of the weekly number of influenza cases during 2011-2012 with the best fitting multivariate model (ARIMAX (2,0,0) _RF), showed that the observed values were within the 95 % confidence interval of the predicted values during 97 of 104 weeks. CONCLUSION: Including rainfall increases the performances of fitted and predicted models. The timing of influenza in Abidjan can be partially explained by rainfall influence, in a setting with little change in temperature throughout the year. These findings can help clinicians to anticipate influenza cases during the rainy season by implementing preventive measures. |
Severe acute respiratory illness deaths in sub-Saharan Africa and the role of influenza: a case-series from 8 countries
McMorrow ML , Wemakoy EO , Tshilobo JK , Emukule GO , Mott JA , Njuguna H , Waiboci L , Heraud JM , Rajatonirina S , Razanajatovo NH , Chilombe M , Everett D , Heyderman RS , Barakat A , Nyatanyi T , Rukelibuga J , Cohen AL , Cohen C , Tempia S , Thomas J , Venter M , Mwakapeje E , Mponela M , Lutwama J , Duque J , Lafond K , Nzussouo NT , Williams T , Widdowson MA . J Infect Dis 2015 212 (6) 853-60 BACKGROUND: Data on causes of respiratory deaths in Africa are limited. METHODS: From January to April 2013, 28 African countries were invited to participate in a review of severe acute respiratory illness (SARI) deaths identified from influenza surveillance during 2009 - 2012. RESULTS: Twenty-three (82%) countries responded, 11 (48%) collect mortality data, and 8 provided data. Data were collected from 37,714 SARI cases and 3091 (8.2%, range by country 5.1-25.9%) tested positive for influenza. There were 1073 (2.8%, range by country 0.1-5.3%) deaths reported among whom 57 (5.3%) were influenza-positive. Case fatality proportion (CFP) was higher among countries with systematic death reporting than those with sporadic reporting. The influenza-associated CFP was 1.8% (57/3091) compared to 2.9% (1016/34,623) for influenza-negative cases (p<0.001). Among 834 (77.7%) deaths tested for other respiratory pathogens, rhinovirus (n=107, 12.8%), adenovirus (n=64, 6.0%), respiratory syncytial virus (n=60, 5.6%), and S. pneumoniae (n=57, 5.3%) were most commonly identified. Among 1073 deaths, 402 (37.5%) were aged 0-4 years, 462 (43.1%) aged 5-49 years, and 209 (19.5%) aged 50 years and older. CONCLUSIONS: Few African countries systematically collect data on respiratory hospitalization outcomes. Stronger surveillance for respiratory deaths may identify risk groups for targeted vaccine use and other prevention strategies. |
Sentinel surveillance of influenza in Burkina Faso: identification of circulating strains during 2010-2012
Tarnagda Z , Yougbaré I , Ilboudo AK , Kagoné T , Sanou AM , Cissé A , Médah I , Yelbéogo D , Nzussouo NT . Influenza Other Respir Viruses 2014 8 (5) 524-9 BACKGROUND: Although influenza surveillance has recently been improved in some sub-Saharan African countries, no information is yet available from Burkina Faso. OBJECTIVES: Our study was the first to determine the prevalence of influenza viruses circulating in Burkina Faso through a sentinel surveillance system. METHODS: We conducted sentinel surveillance with oropharyngeal (OP) swabs collected from outpatients (1 month to 83 years) from six sites in Bobo-Dioulasso and Ouagadougou, among patients meeting the WHO/CDC case definition for influenza-like illness (ILI; fever ≥38°C, and cough and/or sore throat in the absence of other diagnosis) from July 2010 to May 2012. Influenza viruses were detected by real-time RT-PCR using CDC primers, probes, and protocols. RESULTS: The first three ILI cases were enrolled each day; of 881 outpatients with ILI enrolled and sampled, 58 (6.6%) tested positive for influenza viruses (29 influenza A and 29 influenza B). Among the influenza A viruses, 55.2% (16/29) were influenza A (H1N1)pdm09 and 44.8% (13/29) were seasonal A (H3N2). No cases of seasonal A/H1N1 were detected. Patients within 0-5 years and 6-14 years were the most affected, comprising 41.4% and 22.4% laboratory-confirmed influenza cases, respectively. Influenza infections occurred during both the dry, dusty Harmattan months from November to March and the rainy season from June to October with peaks in January and August. CONCLUSIONS: This surveillance was the first confirming the circulation of influenza A (H1N1)pdm09, A/H3N2, and influenza B viruses in humans in Burkina Faso. |
Comparing influenza positivity rates by real-time RT-PCR, elisa and viral culture methods in Cote D'ivoire, West Africa, in 2009
Nzussouo NT , Kadjo HA , Coulibaly D , Ekaza E , Kouakou B , N'Golo DC , Tempia S , Davis R , Dosso M , Thompson M . Afr J Infect Dis 2013 7 (2) 31-35 Detection of circulating influenza strains is a key public health concern especially in limited-resource settings where diagnosis capabilities remain a challenge. As part of multi-site surveillance in Cote d'Ivoire during the 2009 influenza A(H1N1) pandemic, we had the opportunity to test respiratory specimens collected from patients with acute respiratory illness (ARI). We analyzed and compared the percentage of specimens testing positive using three laboratory methods (rtRT-PCR, ELISA, viral culture). From January to October 2009, 1,356 respiratory specimens were collected from patients with acute respiratory illness and shipped at the WHO NIC (Institut Pasteur) Cote d'Ivoire, and 453 (33%) tested positive for influenza by one or more laboratory methods. The proportion of positive influenza tests did not differ by the sex or age of the patient or presenting symptoms, but did differ depending on the timing and site of specimen collection. Of the 453 positive specimens, 424 (93.6%) were detected by PCR, 199 (43.9%) by ELISA and 40 (8.8%) by viral culture. While seasonal influenza A(H1N1) virus strains were prominent, only four 2009 pandemic influenza A(H1N1) cases were detected. Use of molecular biology method (rtRTPCR) increased sensitivity and diagnosis capabilities. Among all three methods used, rRT-PCR was the most sensitive and rapid method. More capacity building is still required for viral culture. Need to collect denominator data in order to have an accurate estimate of the burden of influenza. There was delayed introduction of pandemic influenza A(H1N1)2009 in Cote d'Ivoire. |
Pandemic influenza A(H1N1) in Cote d'Ivoire: health-care providers' knowledge of influenza and attitudes towards vaccination
Coulibaly D , Nzussouo NT , Kadjo HA , Traore Y , Ekra DK , Cherif D , Kouassi PD , N'Gattia A K , Dagnan SN . J Infect Dev Ctries 2013 7 (7) 499-506 INTRODUCTION: During the 2009 influenza A(H1N1) pandemic (pH1N1), different methods were promoted to reduce the spread of influenza, including respiratory etiquette and vaccination. To identify knowledge gaps about influenza and to plan the vaccination campaign against the pandemic in Cote d'Ivoire, a survey was conducted among health-care providers (HCPs) to assess their knowledge about influenza and their willingness to be vaccinated. METHODOLOGY: A cross-sectional survey was performed in the city of Abidjan on 16-18 February 2010, in the three university teaching hospitals, a randomly selected general hospital, and two randomly selected private clinics. In face-to-face interviews, 383 health-care professionals were asked questions about their knowledge of influenza, means of influenza prevention, and their willingness to be vaccinated. Data analysis, both univariate and multivariate, was performed using SPSS. RESULTS: Willingness to be vaccinated against pH1N1 was 80% (n = 284), and 83% of the HCPs would recommend the vaccine to others. The respiratory mode of transmission of influenza was known by 85% (n = 295) of the participants and 50% (n = 174) believed that seasonal influenza virus and pH1N1 virus were different. In a multivariate model, the factors significantly associated with willingness to receive pH1N1vaccine were fear of pH1N1 disease (OR = 2.1; IC = 1.02-4.35), having only a high school education (OR = 8.28; IC = 2.04-33.60), and feeling at risk to contract pH1N1 (OR = 11.43; IC = 4.77-27.38). CONCLUSION: The willingness to be vaccinated against influenza A (H1N1) by health professionals is real. |
Influenza surveillance in 15 countries in Africa, 2006-2010
Radin JM , Katz MA , Tempia S , Nzussouo NT , Davis R , Duque J , Adedeji A , Adjabeng MJ , Ampofo WK , Ayele W , Bakamutumaho B , Barakat A , Cohen AL , Cohen C , Dalhatu IT , Daouda C , Dueger E , Francisco M , Heraud JM , Jima D , Kabanda A , Kadjo H , Kandeel A , Bi Shamamba SK , Kasolo F , Kronmann KC , Mazaba Liwewe ML , Lutwama JJ , Matonya M , Mmbaga V , Mott JA , Muhimpundu MA , Muthoka P , Njuguna H , Randrianasolo L , Refaey S , Sanders C , Talaat M , Theo A , Valente F , Venter M , Woodfill C , Bresee J , Moen A , Widdowson MA . J Infect Dis 2012 206 Suppl 1 S14-21 BACKGROUND: In response to the potential threat of an influenza pandemic, several international institutions and governments, in partnership with African countries, invested in the development of epidemiologic and laboratory influenza surveillance capacity in Africa and the African Network of Influenza Surveillance and Epidemiology (ANISE) was formed. METHODS: We used a standardized form to collect information on influenza surveillance system characteristics, the number and percent of influenza-positive patients with influenza-like illness (ILI), or severe acute respiratory infection (SARI) and virologic data from countries participating in ANISE. RESULTS: Between 2006 and 2010, the number of ILI and SARI sites in 15 African countries increased from 21 to 127 and from 2 to 98, respectively. Children 0-4 years accounted for 48% of all ILI and SARI cases of which 22% and 10%, respectively, were positive for influenza. Influenza peaks were generally discernible in North and South Africa. Substantial cocirculation of influenza A and B occurred most years. CONCLUSIONS: Influenza is a major cause of respiratory illness in Africa, especially in children. Further strengthening influenza surveillance, along with conducting special studies on influenza burden, cost of illness, and role of other respiratory pathogens will help detect novel influenza viruses and inform and develop targeted influenza prevention policy decisions in the region. |
Delayed 2009 pandemic influenza A virus subtype H1N1 circulation in West Africa, May 2009-April 2010
Nzussouo NT , Michalove J , Diop OM , Njouom R , Monteiro Mde L , Adje HK , Manoncourt S , Amankwa J , Koivogui L , Sow S , Elkory MB , Collard JM , Dalhatu I , Niang MN , Lafond K , Moniz F , Coulibaly D , Kronman KC , Oyofo BA , Ampofo W , Tamboura B , Bara AO , Jusot JF , Ekanem E , Sarr FD , Hwang I , Cornelius C , Coker B , Lindstrom S , Davis R , Dueger E , Moen A , Widdowson MA . J Infect Dis 2012 206 Suppl 1 S101-7 To understand 2009 pandemic influenza A virus subtype H1N1 (A[H1N1]pdm09) circulation in West Africa, we collected influenza surveillance data from ministries of health and influenza laboratories in 10 countries, including Cameroon, from 4 May 2009 through 3 April 2010. A total of 10,203 respiratory specimens were tested, of which 25% were positive for influenza virus. Until the end of December 2009, only 14% of all detected strains were A(H1N1)pdm09, but the frequency increased to 89% from January through 3 April 2010. Five West African countries did not report their first A(H1N1)pdm09 case until 6 months after the emergence of the pandemic in North America, in April 2009. The time from first detection of A(H1N1)pdm09 in a country to the time of A(H1N1)pdm09 predominance varied from 0 to 37 weeks. Seven countries did not report A(H1N1)pdm09 predominance until 2010. Introduction and transmission of A(H1N1)pdm09 were delayed in this region. |
Sentinel surveillance for influenza and other respiratory viruses in Cote d'Ivoire, 2003-2010
Kadjo HA , Ekaza E , Coulibaly D , Kouassi DP , Nzussouo NT , Kouakou B , Ouattara A , Adjogoua EV , Akoua-Koffi CG , Elia GA , Victoir K , Bretin-Dosso MC , Mott JA . Influenza Other Respir Viruses 2012 7 (3) 296-303 BACKGROUND: Many countries in Africa have lacked sentinel surveillance systems for influenza and are under-represented in data used for global vaccine strain selection. OBJECTIVES: We describe 8 years of sentinel surveillance data and the contribution of influenza and other viruses to medically attended influenza-like illness (ILI) in Cote d'Ivoire. METHODS: Sentinel surveillance was established in 2003. Nasopharyngeal (NP) specimens and epidemiologic data are collected from persons of all ages presenting with ILI at sentinel sites. Respiratory specimens have been tested for influenza using various viral and molecular diagnostic methods. A subset of 470 specimens collected from children aged 0-5 years were tested for multiple respiratory viruses using RT-PCR. RESULTS: From 2003 to 2010, 5074 NP specimens were collected from patients with ILI. Overall, 969/5074 (19%) of these specimens tested positive for influenza. Seasonal influenza A(H1N1) viruses predominated during 5 years and influenza A(H3N2) viruses predominated during 3 years. Influenza B viruses cocirculated with influenza A viruses during each year from 2004 to 2010. Seasonal peaks in influenza circulation were observed during the months of May, June, and October, with the largest peak corresponding with the primary rainfall season. Of 470 specimens collected from children under aged 5 who were tested for multiple respiratory viruses, a viral respiratory pathogen was detected in 401/470 (85%) of specimens. Commonly detected viruses were RSV (113 of 470 specimens, 24%), rhinoviruses (85/470, 18%), influenza (77/470, 16%), and parainfluenza (75/470, 16%). CONCLUSION: In Cote d'Ivoire, there is a significant annual contribution of influenza and other respiratory viruses to medically attended ILI. |
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