Last data update: Jul 01, 2024. (Total: 47134 publications since 2009)
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Case-control analysis of maternal prenatal analgesic use and cardiovascular malformations: Baltimore-Washington Infant Study
Marsh CA , Cragan JD , Alverson CJ , Correa A . Am J Obstet Gynecol 2014 211 (4) 404 e1-9 OBJECTIVE: To assess maternal prenatal use of analgesics and risk of cardiovascular malformations (CVM) in the offspring. STUDY DESIGN: Data from the Baltimore-Washington Infant Study, a population based case-control investigation of CVM, were used to examine selected isolated CVM diagnoses and maternal analgesic use during the periconceptional period (3 months before and after conception). We compared case and control infants on frequency of maternal use of analgesics and estimated adjusted odds ratios (adjORs) and 95% confidence intervals (CI) with logistic regression models for specific CVM phenotypes. RESULTS: Frequency of periconceptional use of any analgesic was 52% among control mothers and 53% among case mothers. Analyses by CVM diagnoses identified an association of tetralogy of Fallot with maternal acetaminophen use (adjOR=1.6, 95%CI=1.1, 2.3) and dextro-transposition of the great arteries with intact ventricular septum with maternal non-steroidal anti-inflammatory drug use (adjOR=3.2, 95%CI=1.2, 8.7). CONCLUSION: Analgesic use during the periconceptional period was not associated with CVM in the aggregate or with most phenotypes of CVM examined. Associations with two phenotypes of CVM may have occurred by chance. These findings warrant corroboration and further study, including further evaluation of the observed associations, the dose of analgesic taken, more specific timing of analgesic use, and indications for use. |
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