Last data update: Jan 13, 2025. (Total: 48570 publications since 2009)
Records 1-30 (of 78 Records) |
Query Trace: Leichliter JS[original query] |
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Creating a sexually transmitted infection disease intervention workforce for the 21st century
Leichliter JS , Golden MR , Aral SO . Sex Transm Dis 2023 50 S1-S5 Recent and sustained increases in sexually transmitted infections (STI)(1) and the SARS-CoV-2 pandemic,(2) have accelerated technological advances for disease intervention and brought new attention to communicable disease.(3 ) These events provide an opportunity for public health to reflect on the role of disease intervention in curbing infectious disease transmission and focus on methods to enhance and expand existing disease intervention functions. Additionally, substantial federal investment in disease intervention activities make this an opportune time to develop a more robust and nimble disease intervention workforce.(4) Disease intervention includes traditional functions, such as case investigation and contract tracing (CICT, also referred to as partner services), and has been in practice for numerous decades for the control and prevention of infectious diseases such as STI(5). In most instances, the primary focus of disease intervention is to reduce or halt transmission of infections. Within STI prevention, the disease intervention role is often conducted by disease intervention specialists (DIS) or communicable disease investigators (CDI) (referred to as DIS hereafter).(6 ) We propose a model that describes activities conducted by DIS and how these activities can be impacted by public health priorities and the context surrounding their work (Figure). We will discuss how DIS activities and the various contextual factors we highlight can influence or impact each othe |
Successful provision of long-acting reversible contraception in a sexual health clinic
Obafemi OA , Leichliter JS , Maravi M , Alfonsi GA , Shlay JC , Wendel KA , Rietmeijer CA . Sex Transm Dis 2022 49 (6) 443-447 BACKGROUND: Women who attend sexual health clinics are at high risk for sexually transmitted infections and unintended pregnancy. Long-acting reversible contraceptives (LARC) are very effective contraceptive methods, but the provision of LARC in such clinics is not well described in the literature. METHODS: We conducted a retrospective chart review of women who presented to Denver Sexual Health Clinic for any reason and received family planning services between April 1, 2016, and October 31, 2018. We assessed demographic and clinical factors associated with contraceptive method received and conducted a subanalysis of those with intrauterine device (IUD) insertions on the same-day versus delayed insertion. Among those who received an IUD, we assessed rates of pelvic inflammatory disease (PID) 30 days after insertion. RESULTS: Of the 5064 women who received family planning services in our clinic, 1167 (23%) were using a LARC method at the time of their visit. Of the 3897 who were not using a LARC, fewer women, 12.6%, chose LARC (IUD and progestin implant), compared with 33.3% who chose new short-acting reversible contraceptives. Further analysis of the 270 IUD initiators revealed 202 (74.8%) received the IUD on the same day, whereas 68 (25.2%) had delayed IUD insertion. There were 9 incident cases of gonorrhea or chlamydia in those who received same-day IUD and 1 incident case among those who had delayed IUD insertion. There were no cases of PID at 30 days after insertion in either group. CONCLUSIONS: Study findings support IUD provision in a sexual health clinic on the day of initial visit without increased risk of PID. |
Identification of United States counties at elevated risk for congenital syphilis using predictive modeling and a risk scoring system, 2018
Cuffe KM , Torrone E , Hong J , Leichliter JS , Gift TL , Thorpe PG , Bernstein KT . Sex Transm Dis 2021 49 (3) 184-189 BACKGROUND: The persistence of congenital syphilis (CS) remains an important concern in the United States. We use 2018 data to refine a previous predictive model that identifies US counties at elevated risk for CS in 2018. METHODS: Using county-level socioeconomic and health related data from various sources, we developed a logistic regression predictive model to identify county-level factors associated with a county having had ≥1 CS case reported to the National Notifiable Diseases Surveillance System in 2018. We developed a risk scoring algorithm, identified the optimal risk-score cut-point to identify counties at elevated risk, and calculated the live birth to CS case-ratio for counties by predicted risk level to compare counties at elevated risk with counties not at elevated risk. RESULTS: We identified several county-level factors associated with a county having ≥1 CS case in 2018 (area under the curve: 88.6%; Bayesian information criterion: 1551.1). Using a risk score cut-off of ≥8 (sensitivity: 83.2%, specificity: 79.4%), this model captured 94.7% (N = 1,253) of CS cases born in 2018 and identified 850 (27%) counties as being at elevated risk for CS. The live birth to CS case-ratio was lower in counties identified as at elevated risk (2,482) compared to counties categorized as not at elevated risk (10,621). CONCLUSIONS: Identifying which counties are at highest risk for CS can help target prevention efforts and interventions. The relatively low live birth to CS case-ratio in elevated risk counties suggests that implementing routine 28-week screening among pregnant women in these counties may be an efficient way to target CS prevention efforts. |
Increasing sexually transmitted infections among adolescents in the USA
Leichliter JS , Haderxhanaj LT , Obafemi OA . Lancet Child Adolesc Health 2021 5 (9) 609-611 From 2014–2019, reported cases of three nationally notifiable sexually transmitted infections (STI) − chlamydia, gonorrhea, and primary and secondary (P&S) syphilis − have been rising in the United States (US).(https://www.cdc.gov/std/statistics/2019/default.htmhttps://www.cdc.gov/std/statistics/2019/default.htm) During this time, health inequities persisted by age with a higher burden among adolescents and young adults, and by race-ethnicity with a higher burden among subgroups other than non-Hispanic whites and non-Hispanic Asians. Racial-ethnic inequities in STI are also prevalent among adolescents aged 15–19 years. Factors commonly associated with STI that may have contributed to the recent STI increases include sexual behavior and networks, STI testing, and contextual factors (e.g., social determinants). |
Availability of STD and HIV clinical services: ending the HIV epidemic (EHE) vs. non-EHE jurisdictions, 2018
Leichliter JS , Cuffe KM , Kelley KR , Gift TL . Sex Transm Dis 2021 49 (1) e13-e16 We assessed STD/HIV service availability at the primary STD safety net clinic by Phase I EHE jurisdiction status. HIV testing was >90%. In EHE jurisdictions, 22% of primary safety net clinics initiated and/or provided PrEP, 46.6% provided PrEP education or referral only and 29.9% did not provide any PrEP services. |
Extent and sufficiency of STD/HIV disease intervention specialists in the United States of America, 2016
Leichliter JS , Lentine D , Weiss G . Sex Health 2021 18 (3) 280-282 Disease intervention specialists (DIS) conduct partner notification for STD and HIV to interrupt the transmission of STD/HIV. In 2016, we collected information from health departments in the United States of America to determine the number of DIS and whether this number was sufficient for STD/HIV prevention. We identified 1610 STD/HIV DIS positions in the USA and 379 DIS supervisory positions. Of DIS positions, 85% were filled indicating potential issues with turnover. Using nationally reportable data from 2016, we found that states with more primary and secondary syphilis cases had more DIS. DIS participated in public health emergencies in 57% of states. Most USA states indicated that the DIS workforce was not sufficient for STD/HIV prevention. Knowledge of information about DIS workload (e.g. number of STD/HIV cases assigned per DIS) would be helpful. |
Sexual Behavior Among US Adults: New Sex Partners and Number of Lifetime Sex Partners, NHANES 20132016 and NSFG 20112015
Lewis RM , Leichliter JS , Chesson HW , Markowitz LE . Sex Res Social Policy 2021 19 (2) 530-540 Introduction: Sexual behavior information can provide context for understanding rates of sexually transmitted infections (STI) and inform potential impact of interventions. Methods: We used 20132016 National Health and Nutrition Examination Survey (n=4930) and 20112015 National Survey of Family Growth (n=16,643) data from sexually experienced 2044-year old US females and males to estimate the number of lifetime and past year partners and percent with a new past year partner overall and by marital status, in 5-year age groups. Group differences were qualitatively assessed. Results: Estimates from both surveys were comparable. The median number of lifetime sex partners ranged from 4.2 to 5.2 across age groups among females and was higher among older (9.1) than younger (4.6) males, persons with a new past year partner than those without, and persons widowed/divorced/separated/never married than those married/living with partner. Percents with 2 past year partners and a new past year partner were highest in the youngest age group and lower with age. Percent with a new past year partner was 1946 percentage points higher in persons widowed/divorced/separated/never married (range 21.756.4%) compared to persons married/living with partner (range 2.712.4%). Conclusions: In the USA, there are differences in sexual behaviors by gender, age, and marital status. The percent of adults with a new sex partner is lower with increasing age; however, a portion of all subgroups reported having had a new sex partner in the past year indicating some adults remain at risk of acquiring an STI. Policy Implications: These data can help inform policies for STI screening and other interventions. 2021, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply. |
Diverging trends in US male-female condom use by STI risk factors: a nationally representative study
Copen CE , Dittus PJ , Leichliter JS , Kumar S , Aral SO . Sex Transm Infect 2020 98 (1) 50-52 OBJECTIVE: Condom use behaviours are proximal to recent STI increases in the USA, yet it remains unclear whether the use of condoms has changed over time among unmarried, non-cohabiting young men who have sex with women (MSW) and how this variability is influenced by STI risk factors. METHODS: To examine condom use over time among MSW aged 15-29, we used three cross-sectional surveys from the 2002, 2006-2010 and 2011-2017 National Survey of Family Growth. We estimated weighted percentages, adjusted prevalence ratios (APRs) and 95% confidence intervals (CI) to assess changes in condom use, stratified by whether MSW reported any STI risk factors in the past 12 months (ie, perceived partner non-monogamy, male-to-male sex, sex in exchange for money or drugs, sex partner who injects illicit drugs, or an HIV-positive sex partner). RESULTS: We observed a divergence in trends in condom use at last sex between men aged 15 -29 with STI risk factors in the past 12 months and those without such history. We saw significant declines in condom use from 2002 to 2011-2017 among men with STI risk factors (APR=0.80, 95% CI 0.68 to 0.95), specifically among those aged 15-19 (APR=0.73, 95% CI 0.57 to 0.94) or non-Hispanic white (APR=0.71, 95% CI 0.54 to 0.93). In contrast, trends in condom use among men with no STI factors remained stable or increased. Across all time periods, the most prevalent STI risk factor reported was perception of a non-monogamous female partner (23.0%-26.9%). Post-hoc analyses examined whether condom use trends changed once this variable was removed from analyses, but no different patterns were observed. CONCLUSIONS: While STIs have been increasing, men aged 15-29 with STI risk factors reported a decline in condom use. Rising STI rates may be sensitive to behavioural shifts in condom use among young MSW with STI risk factors. |
Assessing partner services provided by state and local health departments, 2018
Cuffe KM , Gift TL , Kelley K , Leichliter JS . Sex Transm Dis 2020 48 (6) 429-435 BACKGROUND: Surveillance reports have shown that reported sexually transmitted diseases (STD) are increasing. The provision of partner services is an effective tool for preventing and reducing the spread of STDs. We examined partner services provided by health departments and assessed for associations with jurisdiction size, STD morbidity, and region. METHODS: We used stratified random sampling to select 668 LHDs and selected all (N=50) SHDs. Rao-Scott chi-square analyses were performed to examine partner services by health department (HD) type (SHD vs LHD), region, jurisdiction size (LHD only), and STD morbidity (LHD only). RESULTS: Approximately 49.0% of LHDs and 88.0% of SHDs responded to the survey. Most LHDs (81.6%) and SHDs (79.5%) provided partner services for some STDs (P=0.63). Compared to SHDs, a higher proportion of LHDs provided expedited partner therapy for chlamydia (66.8% vs 34.2%, P<.01) and gonorrhea (39.3% vs 22.9%, P=0.09). Partner service staff performed other activities such as conducting enhanced surveillance activities (23.0% of LHDs, 34.3% of SHDs, P=0.20) and participating in outbreak response and emergency preparedness (84.8% of LHDs, 80.0% of SHDs, P=0.51). Associations were found when partner services were stratified by HD type, jurisdiction size, STD morbidity, and region. All LHDs in high morbidity areas provided partner services and 45.4% performed serologic testing of syphilis contacts in the field. CONCLUSIONS: A majority of STD programs in LHDs and SHDs provide a variety of partner services and partner service-related activities. It is imperative to continue monitoring the provision of partner services to understand how critical public health needs are being met. |
Using mixed methods and multidisciplinary research to strengthen policy assessments focusing on populations at high risk for sexually transmitted diseases
Thompson K , Cramer R , LaPollo AB , Hubbard SH , Chesson HW , Leichliter JS . Public Health Rep 2020 135 32s-37s Examination of complex public health policy issues can benefit from a mixed methods approach led by multidisciplinary teams.1,2 Evolving problems confronted by law and public health inherently demand dynamic perspectives from diverse fields. However, in practice, professionals often succumb to established ways of approaching an issue within their own disciplines and areas of expertise.3 The mixed methods approach uses quantitative and qualitative research methods to provide a more comprehensive understanding of a research question than any single method could provide. A key advantage of using a mixed methods approach is that the concurrent, coordinated design can offset the weaknesses of either individual approach. Although quantitative research may be inadequate to understand the context in which a phenomenon occurs, qualitative research alone may invoke subjectivity and may not yield generalizable findings. Therefore, the scientific study of the effects of public health law necessitates a multidisciplinary approach.4 A multidisciplinary approach draws on the diverse subject matter expertise, training, and skills of partners from various fields. |
Social and behavioural research prospects for sexually transmissible infection prevention in the era of advances in biomedical approaches
Hogben M , Dittus PJ , Leichliter JS , Aral SO . Sex Health 2020 17 (2) 103-113 In the past two decades, major advances in biomedical intervention approaches to prevent HIV and many sexually transmissible infections (STIs) have shown great promise. However, challenges to prevention remain in the area of achieving population-level impact for biomedical prevention approaches. In this paper we address what social and behavioural research approaches can contribute beyond well-known behaviour change and counselling interventions. We organise work into five areas. Adherence and disinhibition research is primarily into individual-level constructs pertaining to maximising intervention effectiveness. Coverage research represents a population-level construct germane to maximising efficient prioritisation for prevention. Research covering social determinants, a second population-level construct, contributes to both prioritisation and effectiveness. Finally, disparities and social inequities need to be incorporated into prevention, given the pervasive and persistent disparities found in rates of HIV and STIs and in their antecedents. |
Availability of safety-net sexually transmitted disease clinical services in the U.S., 2018
Leichliter JS , O'Donnell K , Kelley K , Cuffe KM , Weiss G , Gift TL . Am J Prev Med 2020 58 (4) 555-561 INTRODUCTION: Safety-net sexually transmitted disease services can prevent transmission of sexually transmitted disease. This study assesses the availability of safety-net sexually transmitted disease clinical services across the U.S. METHODS: A 2018 survey of U.S. local health departments examined the availability of safety-net providers and the availability of specific sexually transmitted disease clinical services, including point-of-care testing and treatment. In 2019, Rao-Scott chi-square tests were used to compare service availability by clinic type (sexually transmitted disease clinic versus other clinics). RESULTS: A total of 326 local health departments completed the survey (49% response rate). Of respondents, 64.4% reported that a clinic in their jurisdiction provided safety-net sexually transmitted disease services. Having a safety-net clinic that provided sexually transmitted disease services was more common in medium and large jurisdictions. Sexually transmitted disease clinics were the primary provider in 40.5% of jurisdictions. A wide range of specific sexually transmitted disease services was offered at the primary safety-net clinic for sexually transmitted diseases. Most clinics offered human papillomavirus vaccination and appropriate point-of-care treatment for gonorrhea and syphilis. Fewer than one-quarter of clinics offered point-of-care rapid plasma reagin or darkfield microscopy syphilis testing. Compared with other clinics, services more commonly offered at sexually transmitted disease clinics included same-day services, hepatitis B vaccination, rapid plasma reagin testing (syphilis), any point-of-care testing for gonorrhea, point-of-care trichomonas testing, and extragenital chlamydia or gonorrhea testing. CONCLUSIONS: One-third of local health departments reported no safety-net sexually transmitted disease services or were not aware of the services, and availability of specific services varied. Without an expansion of resources, local health departments might explore collaborations with healthcare systems and innovations in testing to expand sexually transmitted disease services. |
Identification of United States counties at elevated risk for congenital syphilis using predictive modeling and a risk scoring system
Cuffe KM , Kang JDY , Dorji T , Bowen VB , Leichliter JS , Torrone E , Bernstein KT . Sex Transm Dis 2020 47 (5) 290-295 BACKGROUND: Although preventable through timely screening and treatment, congenital syphilis (CS) rates are increasing in the United States (US), occurring in 5% of counties in 2015. Although individual-level factors are important predictors of CS, given the geographic focus of CS, it is also imperative to understand what county-level factors are associated with CS. METHODS: This is a secondary analysis of reported county CS cases to the National Notifiable Disease Surveillance System (NNDSS) during 2014-15 and 2016-17. We developed a predictive model to identify county-level factors associated with CS and use these to predict counties at elevated risk for future CS. RESULTS: Our final model identified 973 (31.0% of all US counties) counties at elevated risk for CS (sensitivity: 88.1%; specificity: 74.0%). County factors that were predictive of CS included metropolitan area, income inequality, P&S syphilis rates among women and MSM, and population proportions of those who are non-Hispanic Black, Hispanic, living in urban areas, and uninsured. The predictive model using 2014-2015 CS outcome data was predictive of 2016-2017 CS cases (area under the curve value = 89.2%) CONCLUSIONS: Given the dire consequences of CS, increasing prevention efforts remains important. The ability to predict counties at most elevated risk for CS based on county factors may help target CS resources where they are needed most. |
Sexually transmissible infection testing among pregnant women in the US, 2011-15
Leichliter JS , Haderxhanaj LT , Gift TL , Dittus PJ . Sex Health 2019 17 (1) 1-8 Introduction:Sexually transmissible infections (STIs) are increasing in the US. Pregnant women and infants are susceptible to serious STI-related sequelae; however, some STIs can be cured during pregnancy with appropriate, timely screening. Methods: We used data from the 2011-15 National Survey of Family Growth to examine STI testing (in the past 12 months) among women who were pregnant in the past 12 months (n = 1155). In bivariate and multivariable analyses, we examined associations between demographics, health care access and two outcome variables, namely receipt of a chlamydia test and receipt of other STI tests. Results: Among women who were pregnant in the past 12 months, 48% reported receiving a chlamydia test and 54% reported that they received an STI test other than chlamydia in the past 12 months. In adjusted analyses, non-Hispanic Black women were more likely to receive a chlamydia test (adjusted odds ratio (aOR) 2.82; 95% confidence interval (CI) 1.86-4.26) and other STI tests (aOR 2.43; 95% CI 1.58-3.74) than non-Hispanic White women. Women living in a metropolitan statistical area but not the principal city were less likely to report chlamydia (aOR 0.62; 95% CI 0.44-0.86) and other STI (aOR 0.57; 95% CI 0.40-0.81) testing than women living in a principal city. Women born outside the US were significantly less likely to have received a chlamydia test (aOR 0.35; 95% CI 0.19-0.64) or other STI test (aOR 0.34; 95% CI 0.20-0.58), whereas those who had received prenatal care were more likely to receive a chlamydia test (aOR 2.10; 95% CI 1.35-3.28) or another STI test (aOR 2.32; 95% CI 1.54-3.49). Conclusions: The findings suggest that interventions are needed to increase adherence to recommended STI screenings during pregnancy. |
State policies in the United States impacting drug-related convictions and their consequences in 2015
Cramer R , Hexem S , Thompson K , LaPollo AB , Chesson HW , Leichliter JS . Drug Sci Policy Law 2019 5 Background: Criminal justice system involvement has been associated with health issues, including sexually transmitted disease. Both incarceration and sexually transmitted disease share associations with various social conditions, including poverty, stigma, and drug use. Methods: United States state laws (including Washington, D.C.) regarding drug possession and consequences of drug-related criminal convictions were collected and coded. Drug possession policies focused on mandatory sentences for possession of marijuana, crack cocaine and methamphetamines. Consequences of drug-related convictions included ineligibility for public programmes, ineligibility for occupational licences and whether employers may ask prospective employees about criminal history. We analysed correlations between state sexually transmitted disease rates and percentage of a state's population convicted of a felony. Results: First-time possession of marijuana results in mandatory incarceration in one state; first-time possession of crack cocaine or methamphetamines results in mandatory incarceration in 12 (23.5%) states. Many states provide enhanced punishment upon a third possession conviction. A felony drug conviction results in mandatory ineligibility for the Supplemental Nutrition Assistance Program and/or Temporary Assistance for Needy Families in 17 (33.3%) states. Nine (17.6%) states prohibit criminal history questions on job applications. Criminal convictions limit eligibility for various professional licences in all states. State chlamydia, gonorrhoea and syphilis rates were positively associated with the percentage of the state population convicted of a felony (p < 0.05). Conclusion: While associations between crime, poverty, stigma and health have been investigated, our findings could be used to investigate the relationship between the likelihood of criminal justice system interactions, their consequences and public health outcomes including sexually transmitted disease risk. |
Availability of injectable antimicrobial drugs for gonorrhea and syphilis, United States, 2016
Pearson WS , Cherry DK , Leichliter JS , Bachmann LH , Cummings NA , Hogben M . Emerg Infect Dis 2019 25 (11) 2154-2156 We estimated the availability of the injectable antimicrobial drugs recommended for point-of-care treatment of gonorrhea and syphilis among US physicians who evaluated patients with sexually transmitted infections in 2016. Most physicians did not have these drugs available on-site. Further research is needed to determine the reasons for the unavailability of these drugs. |
Self-reported STD-related health services among men who have sex with men in the United States, 2011-17
Haderxhanaj LT , Leichliter JS , Dittus PJ , Spicknall IH , Aral SO . Sex Transm Dis 2019 47 (3) 207-210 From a nationally representative survey, 2011-17, we found that 80.7% of sexually active men who have sex with men were insured and 82.0% had a usual place for care but only 39.8% received sexual risk assessment and 45.8% received STD screening, of whom 58.0% received extragenital STD screening. |
STI risk reduction strategies among US adolescents and adults with multiple opposite-sex sex partners or perceived partner non-monogamy, 2011-2017
Copen CE , Leichliter JS , Spicknall IH , Aral SO . Sex Transm Dis 2019 46 (11) 722-727 BACKGROUND: This study examined condom use and STI testing among unmarried, non-cohabiting women and men who had multiple past-year partnerships or perceived their partner's involvement in another sexual relationship. METHODS: We identified 5,868 and 5,330 unmarried, non-cohabiting sexually active women and men aged 15-44 years using National Survey of Family Growth data for 2011-2017. To measure multiple partnerships, we created four dichotomous variables that included both past-year number of opposite-sex sex partners (one, two or more) and perceived partner non-monogamy (PPNM) (yes, no). Results were stratified by relationship type at last sex ("steady" vs. "casual"). RESULTS: Overall, 39.4% of women and 48.3% of men reported multiple partnerships and 23.4% and 24.0% reported PPNM. Lower condom use was seen for women and men who had two or more partners in the past year and PPNM than those with only one partner and no PPNM (women: 28.5%; 95% confidence interval (CI): 24.1, 32.9 vs. 39.3%; 36.6, 41.9); (men: 37.7%; 33.5, 41.8 vs. 54.9%; 51.9, 57.9). STI testing was higher for groups with PPNM. Men with a steady sex partner had higher prevalence of past-year STI testing if they reported PPNM than not (aPR=2.00; CI: 1.63, 2.45). CONCLUSION: Screening practices that include a standardized sexual risk assessment could identify those with multiple sex partners or PPNM and improve linkage to STI services. Availability of point-of-care tests and expedited partner therapy could provide targeted strategies that prioritize rapid diagnosis and effective partner treatment which may prevent further STI spread. |
STI risk reduction strategies among US adolescents and adults with multiple opposite-sex sex partners or perceived partner non-monogamy, 2011-2017
Copen CE , Leichliter JS , Spicknall IH , Aral SO . Sex Transm Dis 2019 46 (11) 722-727 BACKGROUND: This study examined condom use and STI testing among unmarried, non-cohabiting women and men who had multiple past-year partnerships or perceived their partner's involvement in another sexual relationship. METHODS: We identified 5,868 and 5,330 unmarried, non-cohabiting sexually active women and men aged 15-44 years using National Survey of Family Growth data for 2011-2017. To measure multiple partnerships, we created four dichotomous variables that included both past-year number of opposite-sex sex partners (one, two or more) and perceived partner non-monogamy (PPNM) (yes, no). Results were stratified by relationship type at last sex ("steady" vs. "casual"). RESULTS: Overall, 39.4% of women and 48.3% of men reported multiple partnerships and 23.4% and 24.0% reported PPNM. Lower condom use was seen for women and men who had two or more partners in the past year and PPNM than those with only one partner and no PPNM (women: 28.5%; 95% confidence interval (CI): 24.1, 32.9 vs. 39.3%; 36.6, 41.9); (men: 37.7%; 33.5, 41.8 vs. 54.9%; 51.9, 57.9). STI testing was higher for groups with PPNM. Men with a steady sex partner had higher prevalence of past-year STI testing if they reported PPNM than not (aPR=2.00; CI: 1.63, 2.45). CONCLUSION: Screening practices that include a standardized sexual risk assessment could identify those with multiple sex partners or PPNM and improve linkage to STI services. Availability of point-of-care tests and expedited partner therapy could provide targeted strategies that prioritize rapid diagnosis and effective partner treatment which may prevent further STI spread. |
Trends in factors indicating increased risk for STI among key subpopulations in the United States, 2002-2015
Leichliter JS , Dittus PJ , Copen CE , Aral SO . Sex Transm Infect 2019 96 (2) 121-123 OBJECTIVES: Within the context of rising rates of reportable STIs in the USA, we used national survey data to examine temporal trends in high-risk factors that indicate need for STI/HIV preventive services among key subpopulations with disproportionate STI rates. METHODS: We used data from the 2002 (n=12 571), 2006-2010 (n=22 682) and 2011-2015 (n=20 621) National Survey of Family Growth (NSFG). NSFG is a national probability survey of 15-44 year olds living in US households. We examined STI risk factors among sexually active men who have sex with men (MSM) and Hispanic, non-Hispanic black, 15-19 year old, 20-24 year old, and 25-29 year old women who have sex with men (WSM) and men who have sex with women (MSW). Risk behaviours included: received money or drugs for sex, gave money or drugs for sex, partner who injected drugs, partner who has HIV, non-monogamous partner (WSM, MSW only) and male partner who had sex with other men (WSM only). Endorsement of any of these behaviours was recoded into a composite variable focusing on factors indicating increased STI risk (yes/no). We used chi-squares and logistic regression (calculating predicted marginals to estimate adjusted prevalence ratios (aPRs)) to examine STI risk factors over time among the key subpopulations. RESULTS: From 2002 to 2011-2015, reported STI risk factors did not change or declined over time among key subpopulations in the USA. In adjusted analyses comparing 2002 to 2011-2015, we identified significant declines among WSM: Hispanics (aPR=0.84 (0.68-1.04), non-Hispanic blacks (aPR=0.69 (0.58-0.82), adolescents (aPR=0.71 (0.55-0.91) and 25-29 year olds (aPR=0.76 (0.58-0.98); among MSW: Hispanics (aPR=0.53 (0.40-0.70), non-Hispanic blacks (aPR=0.74 (0.59-0.94) and adolescents (aPR=0.63 (0.49-0.82); and among MSM (aPR=0.53 (0.34-0.84). CONCLUSIONS: While reported STIs have increased, STI risk factors among key subpopulations were stable or declined. Condom use related to these risk factors, sexual mixing patterns and STI testing should be examined. |
Geographic correlates of primary and secondary syphilis among men who have sex with men in the United States
Leichliter JS , Grey JA , Cuffe KM , de Voux A , Cramer R , Hexem S , Chesson HW , Bernstein KT . Ann Epidemiol 2019 32 14-19 e1 PURPOSE: Primary and secondary (P&S) syphilis in men who have sex with men (MSM) has been increasing; however, there is a lack of research on geographic factors associated with MSM P&S syphilis. METHODS: We used multiple data sources to examine associations between social and environmental factors and MSM P&S syphilis rates at the state- and county-level in 2014 and 2015, separately. General linear models were used for state-level analyses, and hurdle models were used for county-level models. Bivariate analyses (P < .25) were used to select variables for adjusted models. RESULTS: In 2014 and 2015 state models, a higher percentage of impoverished persons (2014 beta = 1.24, 95% confidence interval, 0.28-2.20; 2015 beta = 1.19; 95% confidence interval, 0.42-1.97) was significantly associated with higher MSM P&S syphilis rates. In the 2015 county model, policies related to sexual orientation (marriage, housing, hate crimes) were significant correlates of MSM P&S syphilis rates (P < .05). CONCLUSIONS: Our state-level findings that poverty is associated with MSM P&S syphilis are consistent with research at the individual level across different subpopulations and various sexually transmitted diseases. Our findings also suggest that more research is needed to further evaluate potential associations between policies and sexually transmitted diseases. Geographic-level interventions to address these determinants may help curtail the rising syphilis rates and their sequelae in MSM. |
University efforts to address confidentiality issues for STI services
Cuffe KM , Habel MA , Coor AE , Beltran O , Leichliter JS . J Am Coll Health 2018 67 (7) 1-10 OBJECTIVE: This study assessed university policies for addressing confidentiality issues for students seeking STI services. PARTICIPANTS: Universities with sponsored health insurance plans (SHIP) and/or wellness centers were selected from a university health services survey in 2017. METHODS: STI service coverage and polices for addressing confidentiality issues related to explanation of benefit (EOB) forms were stratified by institution type (4-year versus 2-year) and minority serving institution (MSI) status. Rao-Scott chi-square tests were used to assess for differences in STI service coverage and polices. RESULTS: More non-MSIs (61.6%) had SHIPs compared to MSIs (40.0%, p < .001). Only 40.8% of health centers had a policy for addressing EOB-related confidently issues. Of those, the most reported policy was that students could pay out-of-pocket to avoid generating an EOB (36.2%). CONCLUSIONS: Reducing confidentiality barriers are important for STI prevention in students. Universities may consider establishing policies for addressing EOB-related confidentiality concerns. |
Pregnancy, penile-anal sex and other sexual behaviors in the United States, 2011-2015
Leichliter JS , Aral SO . Sex Transm Dis 2018 46 (3) e29-e31 We used US national survey data to examine sexual behavior by pregnancy status and found that, overall, pregnant women did not differ from non-pregnant women in penile-anal sex and associated condom use. Compared to non-pregnant women, pregnant women had lower or similar reports of other sexual behaviors. |
The impact of budget cuts on STD programmatic activities in state and local health departments with staffing reductions in fiscal year 2012
Gift TL , Cuffe KM , Leichliter JS . Sex Transm Dis 2018 45 (11) e87-e89 Staffing reductions in state (SHD) and local health departments (LHD) in fiscal year 2012 were concentrated in disease investigation specialists (DIS) and clinicians (local) and DIS and administrative staff (state). LHDs with budget cuts, were significantly more likely to report reduced partner services if they had staffing reductions. |
State requirements for prenatal syphilis screening in the United States, 2016
Warren HP , Cramer R , Kidd S , Leichliter JS . Matern Child Health J 2018 22 (9) 1227-1232 Objectives This study assesses U.S. state laws related to prenatal syphilis screening, including whether these laws align with CDC screening recommendations and include legal penalties for failing to screen. Methods Statutes and regulations regarding syphilis screening during pregnancy and at delivery effective in 2016 were examined for all 50 U.S. states and the District of Columbia (DC). Targeted search terms were used to identify laws in legal research databases. The timing of the screening mandates for each state law was coded for: (1) first visit, (2) third trimester, and (3) delivery. Descriptive statistics were calculated to examine the number of states with each type of requirement and whether requirements adhered to the CDC STD treatment guidelines. Results Only six states (11.8%) do not require prenatal syphilis screening. Of states with screening requirements (n = 45), the majority (84.3%) require testing at first prenatal visit or soon after. 17 states (33.3%) require screening during the third trimester with five requiring screening only if the patient is considered at high risk. 8 (15.7%) states require screening at delivery with five requiring testing only if the woman is at high risk. 14 (27.5%) states include punishments for failing to screen (civil penalties, criminal penalties and license revocation). Conclusions for Practice Most states had prenatal syphilis screening requirements; a minority corresponded to or extended CDC recommendations. States vary in when they require testing, who must be tested, and whether a failure to screen could result in a punishment for the provider. |
Heterosexual anal and oral sex in adolescents and adults in the United States, 2011-2015
Habel MA , Leichliter JS , Dittus PJ , Spicknall IH , Aral SO . Sex Transm Dis 2018 45 (12) 775-782 BACKGROUND: Heterosexual anal and oral sex are related to the acquisition and transmission of STDs. As common reportable STDs (chlamydia, gonorrhea, and syphilis) in the U.S. are increasing, it is important to understand recent oral and anal sexual behaviors. METHODS: We examined the prevalence and correlates of heterosexual anal and oral sex, associated condom use, and having multiple partners among men and women 15-44 years. RESULTS: Approximately one-third of women and men had ever engaged in anal sex including 11% of adolescents (15-19 years). Most women and men had ever received or given oral sex, at >75%. Six and seven percent of women and men respectively, used a condom at last oral sex compared to 20% and 30% who used a condom at last anal sex. Having multiple sex partners in the past year was most common among adolescents, never or formerly married persons, and those who had a nonmonogamous partner. Less than 10% reported multiple anal sex partners in the past year. A substantial minority had multiple oral or anal sex partners; black women and men had highest reports of oral sex partners by race/ethnicity. CONCLUSIONS: Anal and oral sex are common sexual practices. Given the low rates of condom use during these behaviors, it is important that recommendations for sexual risk assessments are followed. Tailored messaging regarding risk for STD and HIV acquisition during oral and anal sex may benefit adolescents, singles, and divorced individuals. Future discussions regarding the benefits of extragenital STD testing for heterosexuals may be useful. |
Assessing STD partner services in state and local health departments
Cuffe KM , Leichliter JS , Gift TL . Sex Transm Dis 2018 45 (6) e33-e37 State and local health department STD programs provide several partner services to reduce disease transmission. Budget cuts and temporary staff reassignments for public health emergencies may affect the provision of partner services. Determining the impact of staffing reductions on STD rates and public health response should be further assessed. |
The spatial association between federally qualified health centers and county-level reported sexually transmitted infections: A spatial regression approach
Owusu-Edusei K Jr , Gift TL , Leichliter JS , Romaguera RA . Sex Transm Dis 2017 45 (2) 81-86 BACKGROUND: The number of categorical sexually transmitted disease (STD) clinics is declining in the United States. Federally qualified health centers (FQHCs) have the potential to supplement the needed sexually transmitted infection (STI) services. In this study, we describe the spatial distribution of FQHC sites and determine if reported county-level nonviral STI morbidity were associated with having FQHC(s) using spatial regression techniques. METHODS: We extracted map data from the Health Resources and Services Administration data warehouse on FQHCs (ie, geocoded health care service delivery [HCSD] sites) and extracted county-level data on the reported rates of chlamydia, gonorrhea and, primary and secondary (P&S) syphilis (2008-2012) from surveillance data. A 3-equation seemingly unrelated regression estimation procedure (with a spatial regression specification that controlled for county-level multiyear (2008-2012) demographic and socioeconomic factors) was used to determine the association between reported county-level STI morbidity and HCSD sites. RESULTS: Counties with HCSD sites had higher STI, poverty, unemployment, and violent crime rates than counties with no HCSD sites (P < 0.05). The number of HCSD sites was associated (P < 0.01) with increases in the temporally smoothed rates of chlamydia, gonorrhea, and P&S syphilis, but there was no significant association between the number of HCSD per 100,000 population and reported STI rates. CONCLUSIONS: There is a positive association between STI morbidity and the number of HCSD sites; however, this association does not exist when adjusting by population size. Further work may determine the extent to which HCSD sites can meet unmet needs for safety net STI services. |
US public sexually transmitted disease clinical services in an era of declining public health funding: 2013-14
Leichliter JS , Heyer K , Peterman TA , Habel MA , Brookmeyer KA , Arnold Pang SS , Stenger MR , Weiss G , Gift TL . Sex Transm Dis 2017 44 (8) 505-509 BACKGROUND: We examined the infrastructure for US public sexually transmitted disease (STD) clinical services. METHODS: In 2013 to 2014, we surveyed 331 of 1225 local health departments (LHDs) who either reported providing STD testing/treatment in the 2010 National Profile of Local Health Departments survey or were the 50 local areas with the highest STD cases or rates. The sample was stratified by jurisdiction population size. We examined the primary referral clinics for STDs, the services offered and the impact of budget cuts (limited to government funding only). Data were analyzed using SAS, and analyses were weighted for nonresponse. RESULTS: Twenty-two percent of LHDs cited a specialty STD clinic as their primary referral for STD services; this increased to 53.5% of LHDs when combination STD-family planning clinics were included. The majority of LHDs (62.8%) referred to clinics providing same-day services. Sexually transmitted disease clinics more frequently offered extragenital testing for chlamydia and/or gonorrhea (74.7%) and gonorrhea culture (68.5%) than other clinics (52.9%, 46.2%, respectively; P < 0.05). The majority of LHDs (61.5%) reported recent budget cuts. Of those with decreased budgets, the most common impacts were fewer clinic hours (42.8%; 95% confidence interval [CI], 24.4-61.2), reduced routine screening (40.2%; 95% CI, 21.7-58.8) and reductions in partner services (42.1%; 95% CI, 23.6-60.7). One quarter of those with reduced STD budgets increased fees or copays for clients. CONCLUSIONS: Findings demonstrate gaps and reductions in US public STD services including clinical services that play an important role in reducing disease transmission. Furthermore, STD clinics tended to offer more specialized STD services than other public clinics. |
Help and care seeking for sexually transmitted infections among youth in low- and middle-income countries
Newton-Levinson A , Leichliter JS , Chandra-Mouli V . Sex Transm Dis 2017 44 (6) 319-328 BACKGROUND: The ability to seek help or medical care for sexually transmitted infections (STIs) is vital for sexually active youth; yet, their needs are often unmet. METHODS: We conducted a qualitative systematic review of studies to assess youth and provider views about the behaviors of young people in help seeking and care seeking for STI services in low- and middle-income countries. We searched peer-reviewed literature for studies published between 2001 and 2014 with a study population of youth (age, 10–24 years) and/or health service providers. Eighteen studies were identified for inclusion from 18 countries. Thematic analyses identified key themes across the studies. RESULTS: The majority of studies included discussion of youth not seeking treatment, resorting to self-treatment, or waiting to access care, suggesting that many youth still do not seek timely care for STIs. Youth desired more information on sexual health and cited barriers related to fear or taboos in obtaining help or information, especially from providers or parents. Many did not recognize symptoms or waited until symptoms worsened. However, many youth were able to identify a number of sources for STI related care including public and private clinics, pharmacies, alternative healers, and nongovernmental organizations. Youthʼs help seeking and care seeking preferences were frequently influenced by desires for confidentiality, friendliness, and cost. CONCLUSIONS: Youth in low- and middle-income countries experience significant barriers in help seeking for STIs and often do not seek or postpone medical care. Improving uptake may require efforts to address clinic systems, provider attitudes, confidentiality, and cultural norms related to youth sexuality. |
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