Last data update: Oct 28, 2024. (Total: 48004 publications since 2009)
Records 1-3 (of 3 Records) |
Query Trace: Kanphukiew A[original query] |
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Implementing an isoniazid preventive therapy program for people living with HIV in Thailand
Danyuttapolchai J , Kittimunkong S , Nateniyom S , Painujit S , Klinbuayaem V , Maipanich N , Maokamnerd Y , Pevzner E , Whitehead S , Kanphukiew A , Monkongdee P , Martin M . PLoS One 2017 12 (9) e0184986 Treatment of people living with HIV (PLHIV) with latent tuberculosis (TB) infection using isoniazid preventive therapy (IPT) can reduce the risk of TB disease, however, the scale-up of IPT among PLHIV in Thailand and worldwide has been slow. To hasten the implementation of IPT in Thailand, we developed IPT implementation training curricula and tools for health care providers and implemented IPT services in seven large government hospitals. Of the 659 PLHIV enrolled, 272 (41.3%) reported symptoms of TB and 39 (14.3% of those with TB symptoms) were diagnosed with TB. A total of 346 (52.4%) participants were eligible for IPT; 318 (91.9%) of these participants opted to have a tuberculin skin test (TST) and 52 (16.3% of those who had a TST) had a positive TST result. Among the 52 participants with a positive TST, 46 (88.5%) initiated and 39 (75.0%) completed 9 months of IPT: physicians instructed three participants to stop IPT, two participants were lost to follow-up, one chose to stop therapy, and one developed TB. IPT can be implemented among PLHIV in Thailand and could reduce the burden of TB in the country. |
Use of drug-susceptibility testing for management of drug-resistant tuberculosis, Thailand, 2004-2008
Lam E , Nateniyom S , Whitehead S , Anuwatnonthakate A , Monkongdee P , Kanphukiew A , Inyaphong J , Sitti W , Chiengsorn N , Moolphate S , Kavinum S , Suriyon N , Limsomboon P , Danyutapolchai J , Sinthuwattanawibool C , Podewils LJ . Emerg Infect Dis 2014 20 (3) 408-16 In 2004, routine use of culture and drug-susceptibility testing (DST) was implemented for persons in 5 Thailand provinces with a diagnosis of tuberculosis (TB). To determine if DST results were being used to guide treatment, we conducted a retrospective chart review for patients with rifampin-resistant or multidrug-resistant (MDR) TB during 2004-2008. A total of 208 patients were identified. Median time from clinical sample collection to physician review of DST results was 114 days. Only 5.8% of patients with MDR TB were empirically prescribed an appropriate regimen; an additional 31.3% received an appropriate regimen after DST results were reviewed. Most patients with rifampin -resistant or MDR TB had successful treatment outcomes. Patients with HIV co-infection and patients who were unmarried or had received category II treatment before DST results were reviewed had less successful outcomes. Overall, review of available DST results was delayed, and results were rarely used to improve treatment. |
Tuberculosis services and treatment outcomes in private and public health care facilities in Thailand, 2004-2006
Chengsorn N , Bloss E , Anekvorapong R , Anuwatnonthakate A , Wattanaamornkiat W , Komsakorn S , Moolphate S , Limsomboon P , Kaewsa-ard S , Nateniyom S , Kanphukiew A , Varma JK . Int J Tuberc Lung Dis 2009 13 (7) 888-94 BACKGROUND: The World Health Organization recommends that national tuberculosis (TB) programs encourage public and private providers to follow the 'International standards for tuberculosis care'. We assessed services and treatment outcomes in TB patients in public and private facilities to inform public-private mix scale-up in Thailand. METHODS: We prospectively collected data on TB patients in four provinces and the national infectious diseases hospital during 2004-2006. We analyzed services and outcomes among new pulmonary TB patients according to facility type. RESULTS: Of 7526 patients, 4539 (60%) were treated in small public facilities, 2275 (30%) in large public facilities and 712 (10%) in private facilities. Compared with the private sector, more public sector patients had at least two sputum smears examined, were prescribed a standard anti-tuberculosis regimen and received directly observed therapy; however, public sector facilities also performed suboptimally. Treatment outcomes were unsuccessful for 237 (33%) patients in private facilities, and for respectively 1018 (23%) and 655 (29%) patients in small and large public facilities. CONCLUSIONS: TB diagnostic and treatment services and outcomes should be enhanced in both public and private facilities in Thailand. Initiatives are needed to improve treatment outcomes and increase the use of microscopy, standardized TB regimens, and directly observed therapy in the public and private sectors. |
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