Last data update: Jan 27, 2025. (Total: 48650 publications since 2009)
Records 1-4 (of 4 Records) |
Query Trace: Joseph HC[original query] |
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The urgency of resuming disrupted dog rabies vaccination campaigns: a modeling and cost-effectiveness analysis (preprint)
Kunkel A , Jeon S , Joseph HC , Dilius P , Crowdis K , Meltzer MI , Wallace R . medRxiv 2021 2021.04.24.21256032 OBJECTIVE Dog vaccination is a cost-effective approach to preventing human rabies deaths. In Haiti, the 2019 dog vaccination campaign did not include the capital city, and the 2020 campaign was cancelled because of COVID-19 lockdown restrictions and redirection of funds. We estimated the number of human lives that could be saved by resuming dog vaccination in 2021 compared to 2022 and compared the cost-effectiveness of these two scenarios.METHODS We modified a previously published rabies transmission and economic model to estimate trends in dog and human rabies cases in Haiti from 2005-2025. We compared model outputs to surveillance data on human rabies deaths from 2005-2020 and animal rabies cases from 2018-2020. We then estimated the human health and cost implications of restarting dog vaccination programs in either 2021 or 2022.FINDINGS Model predictions and animal surveillance data from Haiti both suggest a 5-to 8-fold increase in animal rabies cases has occurred in the capital city between Fall 2019 and Fall 2020. We estimate that restarting dog vaccination in Haiti in 2021 compared to 2022 could save 285 human lives and prevent 6,541 human rabies exposures over a five-year period and may decrease program costs due to reduced need for human post-exposure prophylaxis.CONCLUSIONS A one-year delay in resuming dog vaccination in Haiti, from 2021 to 2022, could cost hundreds of lives over the next 5 years. Interruptions in dog vaccination campaigns before elimination is achieved can lead to significant human rabies epidemics if not promptly resumed.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo external funding.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:N/A modeling paperAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data are available in the manuscript or supplementary materials. |
Electronic application for rabies management improves surveillance, data quality, and investigator experience in Haiti
Schrodt CA , Dilius P , Gibson AD , Crowdis K , Fénelon N , Ross Y , Bonaparte S , Joseph HC , Wallace RM . Front Vet Sci 2023 10 1052349 BACKGROUND: Integrated bite case management (IBCM) is a multi-sectoral response to animal-bites which reduces human and canine rabies mortality through animal quarantine, bite-victim counseling, and vaccination tracking. Haiti's national rabies surveillance program was established in 2013 using paper-based IBCM (pIBCM) with adoption of an electronic smartphone application (eIBCM) in 2018. METHODS: We evaluated the feasibility of implementing the electronic app in Haiti and compared pIBCM and eIBCM data quality collected January 2013-August 2019. Deaths prevented, cost-per-death averted, and cost-per-investigation during use of pIBCM and eIBCM were estimated using a previously validated rabies cost-effectiveness tool that accounted for bite-victim demographics; probability of acquiring rabies; post-exposure prophylaxis; and costs including training, supplies, and salaries. We compared pIBCM and eIBCM based on data comprehensiveness, completeness, and reporting efficiency. Surveys were administered to IBCM staff to evaluate the usefulness, simplicity, flexibility, and acceptability of eIBCM. RESULTS: Of 15,526 investigations, 79% were paper-based and 21% electronic. IBCM prevented 241 (estimated) human rabies deaths. Using pIBCM, cost-per-death averted was $2,692 and the cost-per-investigation was $21.02; up to 55 data variables were collected per investigation; data transmission took 26 days to reach national staff, and 180 days until analysis. Using eIBCM, the cost-per-death averted was $1,247 and the cost-per-investigation was $22.70; up to 174 data variables were collected per investigation; data transmission took 3 days to reach national staff, and 30 days until analysis. Among 12,194 pIBCM investigations, 55% were mappable by commune, compared to 100% of eIBCM investigations mappable by GPS. Animal case definitions were incorrectly ascribed by investigators in 5.5% of pIBCM investigations and zero for eIBCM; typically, errors were in determining probable vs. suspect case assignments. Overall, eIBCM was well-accepted by staff, who reported the app is easy-to-use, facilitates investigations, and compared to pIBCM hastens data reporting. DISCUSSION: In Haiti, eIBCM showed improved data completeness, data quality, and shorter notification times with minimal increase in operational cost. The electronic app is simple-to-use and facilitates IBCM investigations. Rabies endemic countries could refer to eIBCM in Haiti as a cost-effective means to reduce human rabies mortality and improve surveillance capacity. |
The urgency of resuming disrupted dog rabies vaccination campaigns: a modeling and cost-effectiveness analysis
Kunkel A , Jeon S , Joseph HC , Dilius P , Crowdis K , Meltzer MI , Wallace R . Sci Rep 2021 11 (1) 12476 Dog vaccination is a cost-effective approach to preventing human rabies deaths. In Haiti, the last nation-wide dog vaccination campaign occurred in 2018. We estimated the number of human lives that could be saved by resuming dog vaccination in 2021 compared to 2022 and compared the cost-effectiveness of these two scenarios. We modified a previously published rabies transmission and economic model to estimate trends in dog and human rabies cases in Haiti from 2005 to 2025, with varying assumptions about when dog vaccinations resume. We compared model outputs to surveillance data on human rabies deaths from 2005 to 2020 and animal rabies cases from 2018 to 2020. Model predictions and surveillance data both suggest a 5- to 8-fold increase in animal rabies cases occurred in Haiti's capital city between Fall 2019 and Fall 2020. Restarting dog vaccination in Haiti in 2021 compared to 2022 could save 285 human lives and prevent 6541 human rabies exposures over a five-year period. It may also decrease program costs due to reduced need for human post-exposure prophylaxis. These results show that interruptions in dog vaccination campaigns before elimination is achieved can lead to significant human rabies epidemics if not promptly resumed. |
Notes from the field: A multipartner response to prevent a binational rabies outbreak - Anse-a-Pitre, Haiti, 2019
Adrien J , Georges Y , Augustin PD , Monroe B , Gibson AD , Fenelon N , Fleurinord L , Crowdis K , Mandra A , Joseph HC , Etheart MD , Wallace RM . MMWR Morb Mortal Wkly Rep 2019 68 (32) 707-709 Sustained investments in dog rabies vaccination programs and increased access to postexposure prophylaxis have led to a substantial decrease in rabies deaths associated with dogs in the Western Hemisphere (1). Despite recent dog vaccination campaigns in Pedernales, Dominican Republic, three human rabies deaths associated with dogs were reported during July–December 2018 in Pedernales, which shares a border with Anse-à-Pitre, Haiti (2). Canine rabies is endemic in Haiti and the Dominican Republic; over the past decade, Haiti has reported an eighteenfold increase in laboratory-confirmed canine rabies cases after implementation of an active rabies surveillance program, although none were reported from Anse-à-Pitre (3). Haiti conducted a three-phase national dog rabies vaccination campaign during 2017–2018, with the last round occurring during October 16, 2017–May 22, 2018, in the southern third of the country. However, the campaign did not reach the southeastern community of Anse-à-Pitre because of difficult terrain and funding constraints. Although no human or animal rabies cases had been reported from Anse-à-Pitre, health experts from Haiti and Dominican Republic were concerned that dogs from this community could be part of a cross-border enzootic rabies transmission cycle. At the invitation of the Haiti Ministry of Agriculture, a multiagency team deployed to Haiti to vaccinate dogs, conduct human and animal rabies case surveillance, collect retrospective animal and human rabies exposure and case detection data, and evaluate border crossings by dogs. Because it was an emergency outbreak response, CDC determined the activities to be nonresearch. |
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