Last data update: Sep 23, 2024. (Total: 47723 publications since 2009)
Records 1-2 (of 2 Records) |
Query Trace: Jackson JW [original query] |
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Three cases of neurologic syndrome caused by donor-derived microsporidiosis
Smith RM , Muehlenbachs A , Schaenmann J , Baxi S , Koo S , Blau D , Chin-Hong P , Thorner AR , Kuehnert MJ , Wheeler K , Liakos A , Jackson JW , Benedict T , da Silva AJ , Ritter JM , Rollin D , Metcalfe M , Goldsmith CS , Visvesvara GS , Basavaraju SV , Zaki S . Emerg Infect Dis 2017 23 (3) 387-395 In April 2014, a kidney transplant recipient in the United States experienced headache, diplopia, and confusion, followed by neurologic decline and death. An investigation to evaluate the possibility of donor-derived infection determined that 3 patients had received 4 organs (kidney, liver, heart/kidney) from the same donor. The liver recipient experienced tremor and gait instability; the heart/kidney and contralateral kidney recipients were hospitalized with encephalitis. None experienced gastrointestinal symptoms. Encephalitozoon cuniculi was detected by tissue PCR in the central nervous system of the deceased kidney recipient and in renal allograft tissue from both kidney recipients. Urine PCR was positive for E. cuniculi in the 2 surviving recipients. Donor serum was positive for E. cuniculi antibodies. E. cuniculi was transmitted to 3 recipients from 1 donor. This rare presentation of disseminated disease resulted in diagnostic delays. Clinicians should consider donor-derived microsporidial infection in organ recipients with unexplained encephalitis, even when gastrointestinal manifestations are absent. |
In vitro growth, cytopathic effects and clearance of monolayers by clinical isolates of Balamuthia mandrillaris in human skin cell cultures
Yera H , Dupouy-Camet J , Jackson JW , Sriram R , Sweat S , Goldstein JM , Visvesvara GS . Exp Parasitol 2015 156 61-7 Balamuthia mandrillaris is a free-living ameba (FLA) that has been isolated or its DNA identified in soil, dust and water. It causes a fatal central nervous system infection in humans and animals. Although it is environmental as Acanthamoeba and Naegleria fowleri, the two other free-living amebae that also cause CNS infections in humans and other animals, Balamuthia does not feed on bacteria as the other FLA. In the laboratory, it can be grown on a variety of mammalian cell cultures. In this study we examined the ability of three different Balamuthia isolates to grow on several different human skin cell cultures including the WT/A keratinocyte cell cultures. A corneal isolate of Acanthamoeba castellanii was used for comparison. |
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