Last data update: Jun 11, 2024. (Total: 46992 publications since 2009)
Records 1-4 (of 4 Records) |
Query Trace: Gonzalez-Aviles G [original query] |
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Plasmid-mediated quinolone resistance in isolates of Salmonella enterica serotype Typhi, USA.
Sjolund-Karlsson M , Howie R , Rickert R , Newton A , Gonzalez-Aviles G , Crump JA . Int J Antimicrob Agents 2014 45 (1) 88-90 ![]() Salmonella enterica serotype Typhi is the causative agent of typhoid fever, a severe, systemic, febrile illness. The infection is usually acquired through consumption of water or food contaminated with human faecal material and is therefore more common in areas with poor sanitation and crowding. Typhoid fever was estimated to cause 11.9 million illnesses and 129 000 deaths in 2010 [1]. A large proportion of typhoid fever occurs among infants and children in South-Central and Southeast Asia. Typhoid fever in the USA is often associated with international travel. | Timely treatment with appropriate antimicrobial agents is critical for optimal management of typhoid fever. However, resistance to traditional first-line antimicrobial agents (chloramphenicol, ampicillin and trimethoprim/sulfamethoxazole) is common and has prompted the use of other drugs such as fluoroquinolones (e.g. ciprofloxacin) [2]. In the USA, antimicrobial susceptibility among S. Typhi is monitored by the National Antimicrobial Resistance Monitoring System (NARMS) at the US Centers for Disease Control and Prevention (CDC). |
Typhoid fever acquired in the United States, 1999-2010: epidemiology, microbiology, and use of a space-time scan statistic for outbreak detection
Imanishi M , Newton AE , Vieira AR , Gonzalez-Aviles G , Kendall Scott ME , Manikonda K , Maxwell TN , Halpin JL , Freeman MM , Medalla F , Ayers TL , Derado G , Mahon BE , Mintz ED . Epidemiol Infect 2014 143 (11) 1-12 Although rare, typhoid fever cases acquired in the United States continue to be reported. Detection and investigation of outbreaks in these domestically acquired cases offer opportunities to identify chronic carriers. We searched surveillance and laboratory databases for domestically acquired typhoid fever cases, used a space-time scan statistic to identify clusters, and classified clusters as outbreaks or non-outbreaks. From 1999 to 2010, domestically acquired cases accounted for 18% of 3373 reported typhoid fever cases; their isolates were less often multidrug-resistant (2% vs. 15%) compared to isolates from travel-associated cases. We identified 28 outbreaks and two possible outbreaks within 45 space-time clusters of 2 domestically acquired cases, including three outbreaks involving 2 molecular subtypes. The approach detected seven of the ten outbreaks published in the literature or reported to CDC. Although this approach did not definitively identify any previously unrecognized outbreaks, it showed the potential to detect outbreaks of typhoid fever that may escape detection by routine analysis of surveillance data. Sixteen outbreaks had been linked to a carrier. Every case of typhoid fever acquired in a non-endemic country warrants thorough investigation. Space-time scan statistics, together with shoe-leather epidemiology and molecular subtyping, may improve outbreak detection. |
Genomic dissection of travel-associated extended-spectrum-beta-lactamase-producing Salmonella enterica serovar typhi isolates originating from the Philippines: a one-off occurrence or a threat to effective treatment of typhoid fever?
Hendriksen RS , Leekitcharoenphon P , Mikoleit M , Jensen JD , Kaas RS , Roer L , Joshi HB , Pornruangmong S , Pulsrikarn C , Gonzalez-Aviles GD , Reuland EA , Nashwan AN , Wester AL , Aarestrup FM , Hasman H . J Clin Microbiol 2014 53 (2) 677-80 ![]() One unreported case of ESBL-producing Typhi was identified, whole genome sequence typed among other analysis and compared to other available genomes of Typhi. The reported strain was similar to a previously published strain harbouring blaSHV-12 from the Philippines and likely part of an undetected outbreak; the first of ESBL-producing Typhi. |
Spread of Pacific Northwest Vibrio parahaemolyticus strain
Martinez-Urtaza J , Baker-Austin C , Jones JL , Newton AE , Gonzalez-Aviles GD , DePaola A . N Engl J Med 2013 369 (16) 1573-4 Globally, Vibrio parahaemolyticus is a leading cause of seafood-associated gastroenteritis. Historically, the V. parahaemolyticus serotypes O4:K12 and O4:KUT, which have been shown to be more virulent than other pathogenic V. parahaemolyticus strains, have been unique to the Pacific Northwest region.1 These strains, which were first identified in the Pacific Northwest in 1988, caused large U.S. outbreaks in 1997 and 2004.2 The outbreaks were linked to consumption of Pacific shellfish, but these strains have not been linked to illness or isolated outside the Pacific Northwest until recently. | During the summer of 2012, outbreaks of V. parahaemolyticus infection caused by these serotypes occurred on the Atlantic coasts of the United States and Spain. The U.S. Centers for Disease Control and Prevention received reports of 28 cases of infection from 9 states, and regional health authorities in Galicia in northwest Spain received reports of 51 cases, of which 9 were subsequently confirmed by laboratory tests. | The U.S. outbreak was linked to consumption of shellfish harvested from Oyster Bay Harbor, New York, between April and August 2012. The Spanish outbreak occurred in August 2012 on a cruise ship in Galicia and was epidemiologically linked to cooked seafood cooled with ice produced from untreated local seawater. |
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