Last data update: Jul 01, 2024. (Total: 47134 publications since 2009)
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Query Trace: Frye BL [original query] |
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Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization
McCanlies EC , Yucesoy B , Mnatsakanova A , Slaven JE , Andrew M , Frye BL , Schuler CR , Kreiss K , Weston A . J Occup Environ Med 2010 52 (7) 680-4 ![]() OBJECTIVE: To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS). METHODS: Forty SNPs in six IL genes were evaluated in 85 individuals with CBD, 61 individuals with BeS, and 730 individuals without BeS or CBD (nonsensitized) using a 5' nuclease polymerase chain reaction assay. Logistic regression was used to evaluate the association between IL SNPs, CBD, and BeS, adjusting for plant-site and HLA-DPB1 in additive, dominant, and recessive inheritance models. RESULTS: IL-1A-1142, IL-1A-3769, and IL-1A-4697 were significantly associated with CBD in both the additive and dominant models compared to individuals with BeS or the nonsensitized. CONCLUSIONS: These results indicate that genetic variations in the IL-1A gene may play a role in the development of CBD but not BeS. |
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