Last data update: Apr 22, 2024. (Total: 46599 publications since 2009)
Records 1-9 (of 9 Records) |
Query Trace: Donato C [original query] |
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Public health impacts of underemployment and unemployment in the United States: Exploring perceptions, gaps and opportunities
Pratap P , Dickson A , Love M , Zanoni J , Donato C , Flynn MA , Schulte PA . Int J Environ Res Public Health 2021 18 (19) Background: Unemployment, underemployment, and the quality of work are national occupational health risk factors that drive critical national problems; however, to date, there have been no systematic efforts to document the public health impact of this situation. Methods: An environmental scan was conducted to explore the root causes and health impacts of underemployment and unemployment and highlight multilevel perspectives and factors in the landscape of underemploy-ment and unemployment. Methods: included a review of gray literature and research literature, followed by key informant interviews with nine organizational representatives in employment research and policy, workforce development, and industry to assess perceived needs and gaps in practice. Results: Evidence highlights the complex nature of underemployment and unemployment, with multiple macro-level underlying drivers, including the changing nature of work, a dynamic labor market, inadequate enforcement of labor protection standards, declining unions, wage de-pression, and weak political will interacting with multiple social determinants of health. Empirical literature on unemployment and physical, mental, and psychological well-being, substance abuse, depression in young adults, and suicides is quite extensive; however, there are limited data on the impacts of underemployment on worker health and well-being. Additionally, organizations do not routinely consider health outcomes as they relate to their work in workforce or policy development. Discussion and Conclusions: Several gaps in data and research will need to be addressed in order to assess the full magnitude of the public health burden of underemployment and unemployment. Public health needs to champion a research and practice agenda in partnership with multisector stakeholders to illuminate the role of employment quality and status in closing the gap on health inequities, and to integrate workforce health and well-being into labor and economic development agendas across government agencies and industry. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Epidemiology of cytomegalovirus infection among mothers and infants in Colombia
Rico A , Dollard SC , Valencia D , Corchuelo S , Tong V , Laiton-Donato K , Amin MM , Benavides M , Wong P , Newton S , Daza M , Cates J , Gonzalez M , Zambrano LD , Mercado M , Ailes EC , Rodriguez H , Gilboa SM , Acosta J , Ricaldi J , Pelaez D , Honein MA , Ospina ML , Lanzieri TM . J Med Virol 2021 93 (11) 6393-6397 We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8-12) weeks gestation (n=1,501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5-98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9-18.3; 6/711) per 1,000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%-59.1%) had postnatal infection. This article is protected by copyright. All rights reserved. |
Progressive vaccinia acquired through zoonotic transmission in a patient with HIV/AIDS, Colombia
Laiton-Donato K , Avila-Robayo P , Paez-Martinez A , Benjumea-Nieto P , Usme-Ciro JA , Pinzon-Narino N , Giraldo I , Torres-Castellanos D , Nakazawa Y , Patel N , Wilkins K , Li Y , Davidson W , Burgado J , Satheshkumar PS , Styczynski A , Mauldin MR , Gracia-Romero M , Petersen BW . Emerg Infect Dis 2020 26 (3) 601-605 In March 2015, a patient in Colombia with HIV/AIDS was hospitalized for disseminated ulcers after milking cows that had vesicular lesions on their udders. Vaccinia virus was detected, and the case met criteria for progressive vaccinia acquired by zoonotic transmission. Adherence to an optimized antiretroviral regimen resulted in recovery. |
Detection and Molecular Characterization of Zoonotic Poxviruses Circulating in the Amazon Region of Colombia, 2014.
Usme-Ciro JA , Paredes A , Walteros DM , Tolosa-Perez EN , Laiton-Donato K , Pinzon MD , Petersen BW , Gallardo-Romero NF , Li Y , Wilkins K , Davidson W , Gao J , Patel N , Nakazawa Y , Reynolds MG , Satheshkumar PS , Emerson GL , Paez-Martinez A . Emerg Infect Dis 2017 23 (4) 649-653 During 2014, cutaneous lesions were reported in dairy cattle and farmworkers in the Amazon Region of western Colombia. Samples from 6 patients were analyzed by serologic and PCR testing, and results demonstrated the presence of vaccinia virus and pseudocowpox virus. These findings highlight the need for increased poxvirus surveillance in Colombia. |
Bullying and suicide: a public health approach
Hertz MF , Donato I , Wright J . J Adolesc Health 2013 53 S1-3 Several recent studies have found an association between bullying and depression [1] or bullying and suicide-related behaviors [2], and one study found evidence consistent with a causal link, at least for girls [3,4]. These studies, in conjunction with extensive media coverage of the deaths by suicide of several young people who were victims of bullying, led the Centers for Disease Control and Prevention (CDC) to convene an expert panel focusing on the relationship between bullying involvement and suicide-related behaviors. The purpose of the panel, held in September 2010, was to synthesize the latest research about the relationship between youth involvement in bullying (youth who bully, youth who are bullied, and those who bully and are bullied) and suicide-related behaviors (attempts, fatalities, and risk factors associated with suicide, such as depression). Experts on the topics of bullying and suicide presented their research about the relationship between these two behaviors; their work is contained in this supplement. The panel and this special issue provide clarity around the complicated issues of bullying and suicide among youth. Three key themes emerged: (1) bullying among youth is a significant public health problem; it is prevalent and frequently has detrimental effects; (2) there is a strong association between bullying and suicide-related behaviors, but this relationship is often mediated by other factors, including depression and delinquency; and (3) there are public health strategies that can be applied to the prevention of bullying and suicide. |
Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection
Eby JC , Gray MC , Warfel JM , Paddock CD , Jones TF , Day SR , Bowden J , Poulter MD , Donato GM , Merkel TJ , Hewlett EL . Infect Immun 2013 81 (5) 1390-8 Whooping cough results from infection of the respiratory tract with Bordetella pertussis, and the secreted adenylate cyclase toxin (ACT) is essential for the bacterium to establish infection. Despite extensive study of the mechanism of ACT cytotoxicity and its effects over a range of concentrations in vitro, ACT has not been observed or quantified in vivo, and thus the concentration of ACT at the site of infection is unknown. The recently developed baboon model of infection mimics the prolonged cough and transmissibility of pertussis, and we hypothesized that measurement of ACT in nasopharyngeal washes (NPW) from baboons, combined with human and in vitro data, would provide an estimate of the ACT concentration in the airway during infection. NPW contained up to approximately 10(8) CFU/ml B. pertussis and 1 to 5 ng/ml ACT at the peak of infection. Nasal aspirate specimens from two human infants with pertussis contained bacterial concentrations similar to those in the baboons, with 12 to 20 ng/ml ACT. When approximately 10(8) CFU/ml of a laboratory strain of B. pertussis was cultured in vitro, ACT production was detected in 60 min and reached a plateau of approximately 60 ng/ml in 6 h. Furthermore, when bacteria were brought into close proximity to target cells by centrifugation, intoxication was increased 4-fold. Collectively, these data suggest that at the bacterium-target cell interface during infection of the respiratory tract, the concentration of ACT can exceed 100 ng/ml, providing a reference point for future studies of ACT and pertussis pathogenesis. |
The H1N1 crisis: a case study of the integration of mental and behavioral health in public health crises
Pfefferbaum B , Schonfeld D , Flynn BW , Norwood AE , Dodgen D , Kaul RE , Donato D , Stone B , Brown LM , Reissman DB , Jacobs GA , Hobfoll SE , Jones RT , Herrmann J , Ursano RJ , Ruzek JI . Disaster Med Public Health Prep 2012 6 (1) 67-71 In substantial numbers of affected populations, disasters adversely affect well-being and influence the development of emotional problems and dysfunctional behaviors. Nowhere is the integration of mental and behavioral health into broader public health and medical preparedness and response activities more crucial than in disasters such as the 2009-2010 H1N1 influenza pandemic. The National Biodefense Science Board, recognizing that the mental and behavioral health responses to H1N1 were vital to preserving safety and health for the country, requested that the Disaster Mental Health Subcommittee recommend actions for public health officials to prevent and mitigate adverse behavioral health outcomes during the H1N1 pandemic. The subcommittee's recommendations emphasized vulnerable populations and concentrated on interventions, education and training, and communication and messaging. The subcommittee's H1N1 activities and recommendations provide an approach and template for identifying and addressing future efforts related to newly emerging public health and medical emergencies. The many emotional and behavioral health implications of the crisis and the importance of psychological factors in determining the behavior of members of the public argue for a programmatic integration of behavioral health and science expertise in a comprehensive public health response. |
The integration of mental and behavioral health into disaster preparedness, response, and recovery
Pfefferbaum B , Flynn BW , Schonfeld D , Brown LM , Jacobs GA , Dodgen D , Donato D , Kaul RE , Stone B , Norwood AE , Reissman DB , Herrmann J , Hobfoll SE , Jones RT , Ruzek JI , Ursano RJ , Taylor RJ , Lindley D . Disaster Med Public Health Prep 2012 6 (1) 60-66 The close interplay between mental health and physical health makes it critical to integrate mental and behavioral health considerations into all aspects of public health and medical disaster management. Therefore, the National Biodefense Science Board (NBSB) convened the Disaster Mental Health Subcommittee to assess the progress of the US Department of Health and Human Services (HHS) in integrating mental and behavioral health into disaster and emergency preparedness and response activities. One vital opportunity to improve integration is the development of clear and directive national policy to firmly establish the role of mental and behavioral health as part of a unified public health and medical response to disasters. Integration of mental and behavioral health into disaster preparedness, response, and recovery requires it to be incorporated in assessments and services, addressed in education and training, and founded on and advanced through research. Integration must be supported in underlying policies and administration with clear lines of responsibility for formulating and implementing policy and practice. |
Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles
Donato GM , Goldsmith CS , Paddock CD , Eby JC , Gray MC , Hewlett EL . FEBS Lett 2012 586 (4) 459-65 Bordetella pertussis adenylate cyclase toxin (ACT) intoxicates cells by producing intracellular cAMP. B. pertussis outer membrane vesicles (OMV) contain ACT on their surface (OMV-ACT), but the properties of OMV-ACT were previously unknown. We found that B. pertussis in the lung from a fatal pertussis case contains OMV, suggesting an involvement in pathogenesis. OMV-ACT and ACT intoxicate cells with and without the toxin's receptor CD11b/CD18. Intoxication by ACT is blocked by antitoxin and anti-CD11b antibodies, but not by cytochalasin-D; in contrast, OMV-ACT is unaffected by either antibody and blocked by cytochalasin-D. Thus OMV-ACT can deliver ACT by processes distinct from those of ACT alone. |
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