Last data update: Dec 09, 2024. (Total: 48320 publications since 2009)
Records 1-1 (of 1 Records) |
Query Trace: Cronin LX[original query] |
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Lethal factor toxemia and anti-protective antigen antibody activity in naturally acquired cutaneous anthrax
Boyer AE , Quinn CP , Beesley CA , Gallegos-Candela M , Marston CK , Cronin LX , Lins RC , Stoddard RA , Li H , Schiffer J , Hossain MJ , Chakraborty A , Rahman M , Luby SP , Shieh WJ , Zaki S , Barr JR , Hoffmaster AR . J Infect Dis 2011 204 (9) 1321-7 Cutaneous anthrax outbreaks occurred in Bangladesh from August to October 2009. As part of the epidemiological response and to confirm anthrax diagnoses, serum samples were collected from suspected case patients with observed cutaneous lesions. Anthrax lethal factor (LF), anti-protective antigen (anti-PA) immunoglobulin G (IgG), and anthrax lethal toxin neutralization activity (TNA) levels were determined in acute and convalescent serum of 26 case patients with suspected cutaneous anthrax from the first and largest of these outbreaks. LF (0.005-1.264 ng/mL) was detected in acute serum from 18 of 26 individuals. Anti-PA IgG and TNA were detected in sera from the same 18 individuals and ranged from 10.0 to 679.5 mcg/mL and 27 to 593 units, respectively. Seroconversion to serum anti-PA and TNA was found only in case patients with measurable toxemia. This is the first report of quantitative analysis of serum LF in cutaneous anthrax and the first to associate acute stage toxemia with subsequent antitoxin antibody responses. |
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