Last data update: Jan 27, 2025. (Total: 48650 publications since 2009)
Records 1-4 (of 4 Records) |
Query Trace: Conrad AR[original query] |
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Listeria monocytogenes Illness and Deaths Associated With Ongoing Contamination of a Multi-Regional Brand of Ice Cream Products, United States, 2010-2015.
Conrad AR , Tubach S , Cantu V , Webb LM , Stroika S , Moris S , Davis M , Hunt DC , Bradley KK , Kucerova Z , Strain E , Doyle M , Fields A , Neil KP , Gould LH , Jackson KA , Wise ME , Griffin PM , Jackson BR . Clin Infect Dis 2022 76 (1) 89-95 ![]() ![]() BACKGROUND: Frozen foods have rarely been linked to Listeria monocytogenes illness. We describe an outbreak investigation prompted both by hospital clustering of illnesses and product testing. METHODS: We identified outbreak-associated listeriosis cases using whole-genome sequencing (WGS), product testing results, and epidemiologic linkage to cases in the same Kansas hospital. We reviewed hospital medical and dietary records, product invoices, and molecular subtyping results. Federal and state officials tested product and environmental samples for L. monocytogenes. RESULTS: Kansas officials were investigating five cases of listeriosis at a single hospital when, simultaneously, unrelated sampling for a study in South Carolina identified L. monocytogenes in Company A ice cream products made in Texas. Isolates from four patients and Company A products were closely related by WGS, and the four patients with known exposures had consumed milkshakes made with Company A ice cream while hospitalized. Further testing identified L. monocytogenes in ice cream produced in a second Company A production facility in Oklahoma; these isolates were closely related by WGS to those from five patients in three other states. These ten illnesses, involving three deaths, occurred from 2010 through 2015. Company A ultimately recalled all products. CONCLUSION: In this U.S. outbreak of listeriosis linked to a widely distributed brand of ice cream, WGS and product sampling helped link cases spanning five years to two production facilities, indicating longstanding contamination. Comprehensive sanitation controls and environmental and product testing for L. monocytogenes, with regulatory oversight, should be implemented for ice cream production. |
Notes from the Field: Outbreak of Listeriosis Likely Associated with Prepackaged Caramel Apples - United States, 2017.
Marus JR , Bidol S , Altman SM , Oni O , Parker-Strobe N , Otto M , Pereira E , Buchholz A , Huffman J , Conrad AR , Wise ME . MMWR Morb Mortal Wkly Rep 2019 68 (3) 76-77 ![]() ![]() On December 1, 2017, PulseNet, CDC’s molecular subtyping network for foodborne disease surveillance, identified a cluster of three Listeria monocytogenes clinical isolates with indistinguishable pulsed-field gel electrophoresis (PFGE) pattern combinations. These isolates were closely related to one another by whole-genome multilocus sequence typing within three allele differences (range = 0–3 alleles), indicating that the infections were likely from the same source. CDC, the Food and Drug Administration (FDA), and state and local health departments initiated a multistate investigation. An outbreak case of listeriosis was defined as an infection with L. monocytogenes, with an isolate that was indistinguishable by PFGE and closely related by whole-genome multilocus sequence typing to the outbreak strain isolated during October–December 2017. |
Multistate outbreak of Listeria monocytogenes infections linked to whole apples used in commercially produced, prepackaged caramel apples: United States, 2014-2015.
Angelo KM , Conrad AR , Saupe A , Dragoo H , West N , Sorenson A , Barnes A , Doyle M , Beal J , Jackson KA , Stroika S , Tarr C , Kucerova Z , Lance S , Gould LH , Wise M , Jackson BR . Epidemiol Infect 2017 145 (5) 1-9 ![]() ![]() Whole apples have not been previously implicated in outbreaks of foodborne bacterial illness. We investigated a nationwide listeriosis outbreak associated with caramel apples. We defined an outbreak-associated case as an infection with one or both of two outbreak strains of Listeria monocytogenes highly related by whole-genome multilocus sequence typing (wgMLST) from 1 October 2014 to 1 February 2015. Single-interviewer open-ended interviews identified the source. Outbreak-associated cases were compared with non-outbreak-associated cases and traceback and environmental investigations were performed. We identified 35 outbreak-associated cases in 12 states; 34 (97%) were hospitalized and seven (20%) died. Outbreak-associated ill persons were more likely to have eaten commercially produced, prepackaged caramel apples (odds ratio 326.7, 95% confidence interval 32.2-3314). Environmental samples from the grower's packing facility and distribution-chain whole apples yielded isolates highly related to outbreak isolates by wgMLST. This outbreak highlights the importance of minimizing produce contamination with L. monocytogenes. Investigators should perform single-interviewer open-ended interviews when a food is not readily identified. |
Two Listeria monocytogenes pseudo-outbreaks caused by contaminated laboratory culture media
Matanock A , Katz LS , Jackson KA , Kucerova Z , Conrad AR , Glover WA , Nguyen V , Mohr MC , Marsden-Haug N , Thompson D , Dunn JR , Stroika S , Melius B , Tarr C , Dietrich SE , Kao AS , Kornstein L , Li Z , Maroufi A , Marder EP , Meyer R , Perez-Osorio AC , Reddy V , Reporter R , Carleton H , Tweeten S , Waechter H , Yee LM , Wise ME , Davis K , Jackson B . J Clin Microbiol 2015 54 (3) 768-70 Listeriosis is a serious foodborne infection that disproportionately affects elderly adults, pregnant women, newborns, and immunocompromised individuals. Diagnosis is made by culturing Listeria monocytogenes from sterile body fluids or products of conception. This report describes investigations of two listeriosis pseudo-outbreaks caused by contaminated laboratory media made from sheep blood. |
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