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CDC Science Clips
COVID-10 GPH

Last data update: Apr 28, 2025. (Total: 49156 publications since 2009)
(Author names in bold with hyperlink are CDC authors)
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Query Trace: CDC NCI NHANES III Genomics Working Group[original query]
Lead and cognitive function in VDR genotypes in the third National Health and Nutrition Examination Survey.
Krieg EF Jr , Butler MA , Chang MH , Liu T , Yesupriya A , Lindegren ML , Dowling N , CDC NCI NHANES III Genomics Working Group .
Neurotoxicol Teratol 2009 32 (2) 262-72 type

The relationship between the blood lead concentration and cognitive function in children and adults with different VDR genotypes who participated in the third National Health and Nutrition Examination Survey was investigated. The relationship between blood lead and serum homocysteine concentrations was also investigated. In children 12 to 16years old, performance on the digit span and arithmetic tests as a function of the blood lead concentration varied by VDR rs2239185 and VDR rs731236 genotypes. Decreases in performance occurred in some genotypes, but not in others. In adults 20 to 59years old, performance on the symbol-digit substitution test as a function of the blood lead concentration varied by VDR rs2239185-rs731236 haplotype. In the 12 to 16year old children and adults 60 or more years old, the relationship between the serum homocysteine and blood lead concentrations varied by VDR genotype. The mean blood lead concentrations of the children and adults did not vary by VDR genotype.
Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey.
Krieg EF Jr , Butler MA , Chang MH , Liu T , Yesupriya A , Lindegren ML , Dowling N , CDC NCI NHANES III Genomics Working Group .
Neurotoxicol Teratol 2009 31 (6) 364-71 type

The relationship between the blood lead concentration and cognitive function in children and adults with different ALAD genotypes who participated in the third National Health and Nutrition Examination Survey was investigated. The relationship between blood lead and serum homocysteine concentrations was also investigated. In children 12 to 16 years old, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. In adults 20 to 59 years old, mean reaction time decreased as the blood lead concentration increased in the ALAD rs1800435 CC/CG group. This represents an improvement in performance. In adults 60 years and older, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. The serum homocysteine concentration increased as the blood lead concentration increased in adults 20 to 59 years old and 60 years and older, but there were no differences between genotypes. The mean blood lead concentration of children with the ALAD rs1800435 CC/CG genotype was less than that of children with the GG genotype.
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