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COVID-10 GPH

Last data update: Apr 18, 2025. (Total: 49119 publications since 2009)
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Query Trace: Bradley-Ferrell BL[original query]
Effect of prior influenza a(H1N1)pdm09 virus infection on pathogenesis and transmission of human influenza A(H5N1) clade 2.3.4.4b virus in ferret model
Sun X , Belser JA , Li ZN , Brock N , Pulit-Penaloza JA , Kieran TJ , Pappas C , Zeng H , Chang JC , Carney PJ , Bradley-Ferrell BL , Stevens J , Tumpey TM , Levine MZ , Maines TR .
Emerg Infect Dis 2025 31 (3) 458-466 type

Reports of human infections with influenza A(H5N1) clade 2.3.4.4b viruses associated with outbreaks in dairy cows in the United States underscore the need to assess the potential cross-protection conferred by existing influenza immunity. We serologically evaluated ferrets previously infected with an influenza A(H1N1)pdm09 virus for cross-reactive antibodies and then challenged 3 months later with either highly pathogenic H5N1 clade 2.3.4.4b or low pathogenicity H7N9 virus. Our results showed that prior influenza A(H1N1)pdm09 virus infection more effectively reduced the replication and transmission of the H5N1 virus than did the H7N9 virus, a finding supported by the presence of group 1 hemagglutinin stalk and N1 neuraminidase antibodies in preimmune ferrets. Our findings suggest that prior influenza A(H1N1)pdm09 virus infection may confer some level of protection against influenza A(H5N1) clade 2.3.4.4.b virus.
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