Health care continues to change rapidly, growing increasingly complex with greater acuity of patients, delivery of more care outside of traditional acute care settings, and ongoing challenges related to staffing and personnel turnover. Despite this, we remain determined to provide safe care for every patient and a safe workplace for each of our staff. Such determination requires every health care facility, whether an urban tertiary care center or a critical access hospital, an ambulatory surgery center or a skilled-nursing facility, to ensure that everyone providing patient care or working to support the environment of care is prepared to do their part to prevent the spread of infections. Not only does each facility need to do its part, the frequent movement of patients from one care setting to the next means that infection prevention and control (IPC) efforts must also be coordinated across the range of facility types that make up modern health care.